Orthopedics

Latest AI and machine learning research in orthopedics for healthcare professionals.

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Showing 921-940 of 8,094 articles

Unsupervised Machine Learning Drives Dynamic Alignment Classification In Navigated Total Knee Arthroplasty.

BACKGROUND: Current classifications used for total knee arthroplasty (TKA) are static and fail to capture the dynamic behavior of the limb during gait. This study introduces a novel intraoperative method to measure dynamic hip-knee angle (dHKA) using an intra-articular device coupled with a computer-assisted orthopaedic surgery (CAOS) system. This device applies a quasi-constant distraction force ...

Apr 30 2026 42069019

AI-based knee osteoarthritis progression prediction: a comprehensive global bibliometric and hotspot evolution analysis (2010-2025).

BACKGROUND: Knee osteoarthritis (OA) is a leading global cause of disability, yet conventional tools lack sensitivity for early detection and precise prognostication. Artificial intelligence (AI) and machine learning (ML) offer powerful means to enhance prediction of knee OA onset and progression. This bibliometric study maps global research trends and thematic evolution rather than evaluating the...

Apr 30 2026 42063116
The challenge of bringing advances in sacroiliac joint imaging to the clinic.

PURPOSE OF REVIEW: Recently reported criteria are more stringent for classification of axial spondyloarthritis (axSpA) in the absence of positive imag...

Apr 30 2026 42059098
Integrated High-Throughput Targeted Metabolomics and Machine Learning for Early Prediction and Prevention of Postoperative Delirium in Older Adult Surgical Patients: Prospective Multicenter Cohort Study.

BACKGROUND: Postoperative delirium (POD) is a common and severe complication in older adult patients with hip fracture, yet its pathogenesis remains u...

Apr 30 2026 42060542
Participant-Aware Model Validation for Repeated-Measures Data: Comparative Cross-Validation Study.

BACKGROUND: Repeated-measures datasets are common in biomechanics and digital health, where each participant contributes multiple correlated trials. I...

Apr 30 2026 42060920
Deep Learning-Based Identification of Surgical Candidacy for Cervical Spinal Cord Decompression.

BACKGROUND: Artificial intelligence has previously demonstrated the capability to interpret cervical spine imaging. The present study aims to identify...

Apr 30 2026 42061991
Assessing osteosarcopenia using automated multi-structure-segmentation and Hounsfield unit-based analysis of lumbar muscles and vertebral bodies on computed tomography.

Sarcopenia and osteoporosis are prevalent age-related conditions that substantially increase the risk of falls, fractures, and functional decline. Thi...

Apr 30 2026 42062358
The complexity of pain in osteoarthritis.

Chronic pain is the hall-mark symptom of osteoarthritis (OA) and although several therapies are available, a sizeable number of patients do not gain a...

Apr 30 2026 42062510
Identification and Screening of Lactate-Related Genes as Molecular Markers for Early Diagnosis of Steroid-Induced Osteonecrosis of the Femoral Head.

Steroid-induced osteonecrosis of the femoral head (SONFH) is a major cause of disability among young and middle-aged adults. However, current diagnosi...

Apr 30 2026 41982156
Effect of markers in training dataset for markerless applications in biomechanics.

The quality of dataset annotations used to train markerless motion capture models is crucial for obtaining reliable joint center estimations from vide...

Apr 29 2026 42085951
Radiomics for predicting microsatellite instability-high status in colorectal cancer: a systematic review and meta-analysis.

OBJECTIVE: Microsatellite instability (MSI) has emerged as a key predictive biomarker for chemotherapy and immunotherapy response, and as a prognostic...

Apr 29 2026 42057077
Quantitative CT Measurements of Interstitial Lung Disease: Same-Day Variability Between Two Vendors-A Prospective Study.

BACKGROUND. Clinical application of quantitative CT (QCT) measurements of interstitial lung disease (ILD) for longitudinal monitoring of disease progr...

Apr 29 2026 41474222
Rotenone impairs osteoclastogenesis by inhibiting cell migration: insights from machine learning.

PURPOSE: The migration and fusion of osteoclast precursors (OCPs) are critical steps in osteoclastogenesis and require substantial energy. Although ox...

Apr 29 2026 42051150
Design of Safe and Efficient Adenine Base Editors via Protein Language Model Screening for Osteoarthritis Treatment.

Base editors enable precise genome modification and have emerged as a promising therapeutic approach for correcting diseases caused by single-nucleoti...

Apr 29 2026 42052652
Explainable machine learning differentiates necrotizing fasciitis and osteomyelitis via routine blood biomarkers.

Necrotizing fasciitis (NF) and osteomyelitis (OM) are severe, limb-threatening infections with overlapping features, making early differentiation chal...

Apr 29 2026 42056542
Functional evaluation in adult spinal deformity can be reduced to 3 key kinematic parameters that can sufficiently predict health-related quality of life outcomes: an observational prospective study.

BACKGROUND CONTEXT: Recently, functional evaluation using 3D gait analysis (3DGA) proved to predict health-related quality-of-life (HRQOL) scores bett...

Apr 28 2026 42061763
Anatomy data driven mechanical adaptation of bone tunnel-screw interface in ACL reconstruction.

PURPOSE: Anatomical information about bone microstructure at the anterior cruciate ligament attachment sites could guide biomimetic strategies in ante...

Apr 28 2026 42061491
Serpinh1 promotes fracture healing by enhancing osteogenesis via activation of the Wnt/β-catenin signaling pathway.

BACKGROUND: The process of fracture healing encompasses tightly regulated cellular and molecular interactions. However, the precise regulatory mechani...

Apr 28 2026 42102673
How receptor conformation depends on lipid nanodisc size: Adenosine A2A receptor and implications for class-A GPCR proteins.

Nanodiscs have become an exceptionally valuable tool to explore membrane proteins in an environment resembling native membranes. However, it remains u...

Apr 28 2026 42061733
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