Osteoporosis

Activating the SDF-1/CXCR4 axis: Notoginsenoside R1-Functionalized zinc scaffolds accelerate fracture healing and angiogenesis in diabetic osteoporosis.

Effective treatment of diabetic osteoporotic fractures (DOF) requires biomaterials capable of promoting vascularized bone regeneration. A biodegradable porous zinc (Zn) scaffold incorporating sustained-release Notoginsenoside R1 (NGR1), referred to as Zn-NGR1, was developed using powder metallurgy and impregnation techniques. Comprehensive characterization by scanning electron microscopy (SEM), en...

Intelligent identification of osteoporosis on hip X-rays using vision transformer.

OBJECTIVE: This study aimed to develop and evaluate a deep learning model based on the Vision Transformer (ViT) architecture for the automatic classification of hip X-ray images into three categories: normal bone mass, osteopenia, and osteoporosis. The goal was to explore the model's potential for early screening and auxiliary diagnosis of osteoporosis. METHODS: A total of 3016 hip anteroposterior...

The Diagnostic Value of Image-Based Machine Learning for Osteoporosis: Systematic Review and Meta-Analysis.

BACKGROUND: Osteoporosis (OP) is projected to be a major issue significantly impacting the well-being of middle-aged and old populations. Machine lear...

The balance between artificial and human intelligence in clinical practice.

INTRODUCTION: Artificial intelligence (AI) is becoming increasingly integrated into clinical care in hand surgery. Its applications extend across diag...

Medicinal chemistry meets nanotechnology: machine learning assisted colorimetric sensing platform for oxalic acid based on drug mediated copper oxide nanoparticles.

Increased levels of oxalic acid are associated with an increased risk of kidney stone formation, which can lead to renal failure. In addition, its hig...

Acute pancreatitis: mechanisms and therapeutic approaches.

Acute pancreatitis is a complex inflammatory condition characterized by sudden onset and rapid progression, with severe cases often associated with hi...

Identification of Risk Factors and Development of Machine Learning Prediction Models for Inpatient Calcium Pyrophosphate Deposition Disease Flares.

OBJECTIVE: The risk factors for inpatient calcium pyrophosphate deposition disease (CPPD) flares remain poorly defined. This study aimed to identify i...

Multicenter evaluation of interpretable AI for coronary artery disease diagnosis from PET biomarkers.

Positron emission tomography (PET)/computed tomography (CT) for myocardial perfusion imaging (MPI) provides multiple imaging biomarkers, often evaluat...

Exploring the molecular intersections of osteoporosis and sarcopenia: An integrated bioinformatics and experimental validation.

BACKGROUND: Osteoporosis and sarcopenia are age-related degenerative diseases that frequently co-occur in the older adults, yet their shared molecular...

Coronary artery calcium clinical utilization: An update.

Coronary artery disease (CAD) remains a leading cause of mortality and morbidity worldwide. Coronary artery calcification (CAC) is a well-established ...

Multi-scale heart simulation augments the explainability of artificial intelligence-enabled electrocardiogram through provision of an electrocardiogram database labelled with cellular pathologies.

BACKGROUND AND OBJECTIVES: Although artificial-intelligence-enhanced electrocardiograms (AI-ECGs) offer prediction and diagnosis capabilities superior...

From bench to bedside: The clinical relevance of atrial electrical remodeling in atrial fibrillation therapy.

Atrial electrical remodeling spans molecular, electrical, and structural alterations that shorten refractoriness, facilitate reentry, and ultimately c...

Multi-omics integration identifies CACNG3 as a synaptic calcium channel regulator in Alzheimer's disease: Mechanistic insights and therapeutic implications.

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, memory impairment, and impaired daily functio...

Coronary artery segmentation in non-contrast calcium scoring CT images using deep learning.

Precise localization of coronary arteries in Computed Tomography (CT) scans is critical from the perspective of medical assessment of various heart pa...

ANGPTL4 regulates the adipogenic-osteogenic differentiation balance of bone marrow mesenchymal stem cells: A novel mechanism of osteoporosis from the perspective of lipid metabolism.

To investigate the role of lipid metabolism abnormalities in the progression of osteoporosis (OP), clarify the impact of the key regulator angiopoieti...

Construction and validation of a machine learning-based risk prediction model for invasive mechanical ventilation in AECOPD patients complicated with respiratory failure.

OBJECTIVE: This study aimed to create and validate a machine learning (ML) model to predict the likelihood of invasive mechanical ventilation (IMV) in...

Methodological Variations in 24-Hour Urine Collection for Nephrolithiasis: A Systematic Review of Reporting Practices and Clinical Implications.

BACKGROUND: A 24-hour urine collection is central to the metabolic evaluation and prevention of nephrolithiasis. Despite its widespread use, methodolo...

Deep learning-based micro-CT grayscale analysis for early detection and staging of osteoporosis in rats.

BACKGROUND: Rat models are widely used in preclinical osteoporosis research to study disease mechanisms and evaluate therapies. Current Micro-CT studi...

eCAPRI: a novel tool combining clinical and imaging data for post-TAVI mortality prediction.

OBJECTIVES: Transcatheter aortic valve implantation (TAVI) is crucial for treating calcified aortic stenosis (CAS), yet post-procedural outcomes remai...

Exploring Patients' Profiles Associated With the Resolution of Acute Calcium Pyrophosphate Arthritis Treated With Colchicine and Prednisone: Post Hoc Analysis of a Randomized Controlled Trial.

OBJECTIVE: The objective was to identify factors determining acute arthritis resolution and safety with colchicine and prednisone in acute calcium pyr...