Latest AI and machine learning research in osteoporosis for healthcare professionals.
Proteins' flexibility is a feature in communicating changes in cell signaling instigated by binding with secondary messengers, such as calcium ions, associated with the coordination of muscle contraction, neurotransmitter release, and gene expression. When binding with the disordered parts of a protein, calcium ions must balance their charge states with the shape of calcium-binding proteins and th...
Background: Quantitative susceptibility mapping (QSM) of the brain is an advanced MRI technique for assessing tissue characteristics based on magnetic susceptibility, which varies with the composition of the tissue, such as iron, calcium, and myelin levels. QSM consists of multiple processing steps, with various choices for each step. Despite its increasing application in detecting and monitorin...
Calcium imaging has become a powerful alternative to electrophysiology for studying neuronal activity, offering spatial resolution and the ability t...
Despite coronary artery calcium scoring being considered a largely solved problem within the realm of medical artificial intelligence, this paper ar...
By use of complex network dynamics and graph-based machine learning, we identified critical determinants of lineage-specific plasticity across the s...
Biophysiscal neuron models provide insights into cellular mechanisms underlying neural computations. However, a central challenge has been the questio...
Understanding how the brain represents sensory information and triggers behavioural responses is a fundamental goal in neuroscience. Recent advances i...
Core body temperature (Tb) is defended within narrow limits through thermoregulatory behaviors like huddling, nesting, and physical activity as well a...
Cognition relies on the function of local and long-range neural circuits in the neocortex, which are dynamically regulated by neuromodulatory signals ...
Effective treatment of chronic pain remains hindered by the lack of drug delivery systems that simultaneously achieve long-term stability, high spatia...
The mammalian prefrontal cortex encodes variables related to goal-directed behavior, and enables flexibility during environmental changes, making it c...
Mutation in calcium-binding proteins (CBPs) can significantly influence Ca2+ binding affinity (BA), resulting in substantial impairment in the signali...
Resting-state hemodynamic fluctuations are closely linked to gamma-band neural activity, yet the cellular drivers of this neurovascular coupling remai...
Time processing requires distributed and coordinated cortical dynamics. Flexible yet robust temporal representations can arise from two distinct compu...
The free-energy principle has been proposed as a unified theory of brain function, and recent evidence from in vitro experiments supports its validity...
Systems neuroscience has experienced an explosion of new tools for reading and writing neural activity, enabling exciting new experiments (e.g., all-o...
Quantitative phenotyping of Caenorhabditis elegans is essential across numerous fields, yet data extraction remains a significant analytical bottlenec...
Intracellular calcium ion (Ca2+) exhibits diverse dynamical behaviors, including complex oscillations such as bursting and chaos. The distinction of d...
With a general increase in human lifespan, the need for technological advances to develop strategies for healthy aging has assumed great importance. I...
Axon termination is a critical step in neural circuit formation, but the contribution of activity from postsynaptic targets to this process remains un...