Latest AI and machine learning research in osteoporosis for healthcare professionals.
Cooperation is a hallmark of social species, enabling individuals to achieve goals that are unattainable alone. Across species, cooperative behaviors are often organized by distinct social roles such as leaders and followers, yet the neural mechanisms supporting such role-based coordination remain elusive. Here we introduce a new paradigm for studying cooperation in mice, where pairs of animals en...
All cells in an animal collectively ensure, moment-to-moment, the survival of the whole organism in the face of environmental stressors1,2. Physiology seeks to elucidate the intricate network of interactions that sustain life, which often span multiple organs, cell types, and timescales, but a major challenge lies in the inability to simultaneously record time-varying cellular activity throughout ...
The ion channel (IC) genes encoded in the human genome play fundamental roles in cellular functions and disease and are one of the largest classes of ...
Although the autonomic sympathetic system is activated in parallel with locomotion, the underlying neural mechanisms mediating this coordination are n...
The brain can flexibly reorganize the structure of action sequence, or motor programs, to efficiently reach positive outcomes. These behavioral adapta...
Tissues rely on supracellular signals to coordinate their cells over a long range. Two such tissue-scale cues are calcium waves and patterns of cell-c...
Electrical stimulation has been widely used to probe neural network properties and treat dysfunction. Electrocorticography (ECoG) electrodes, long use...
Astrocytes influence synaptic plasticity and neuronal function through astrocytic calcium dynamics (ACD). However, astrocytes’ contribution to cogniti...
Astrocytes regulate the activity of nearby neurons so disruption of astrocyte calcium dynamics by traumatic brain injury (TBI) could have profound con...
The Master Athletic Laboratory Study of Intramuscular Connective Tissue (MALICoT, DRKS00015764) set out to analyze the endomysium content of the human...
The current state of mental health treatment for individuals diagnosed with major depressive disorder leaves billions of individuals with first-line t...
Neuroscience drug discovery is challenged by the brain’s structural and cell-type complexity, which is difficult to model in cellular systems compatib...
Adaptive behavior requires flexible encoding of emotional valence. Although striatal acetylcholine (ACh) signaling is critical for reinforcement learn...
Cortical population activity unfolds along structured trajectories in state space, reflecting underlying dynamics of the neural networks involved. How...
Computational neuroscience currently debates two competing hypotheses to explain hierarchical learning in the neocortex: deep learning inspired approx...
The CACNA1C gene encodes the CaV1.2 L-type voltage-gated calcium channel, which plays a crucial role in neuronal signaling. CACNA1C is a risk gene for...
To address the limitations of calcium imaging data, we propose a segmentation-agnostic deep learning framework that integrates Quantile-Based Time-Ser...
State-of-the-art computational models of vision largely focus on fitting trial-averaged spike counts to visual stimuli using overparameterized neural ...
Chronological age is a cornerstone of medical decision-making but is limited because individuals age at different rates. We recently released an open-...
While mammography is commonly used for breast cancer detection, its widespread implementation in resource-constrained nations is challenging. Artifici...