Other Cancers

AI-Guided Design of pH- and Redox-Responsive Lignin@GO@ZIF-8 Nanocarriers for Targeted Co-Delivery of 5-Fluorouracil and Metformin in Prostate Cancer Therapy.

Prostate cancer therapy is limited by systemic toxicity and inefficient tumor-selective delivery. He...

Identification and validation of NETs-related biomarkers in hepatocellular carcinoma through bioinformatics analysis and machine learning algorithms.

BACKGROUND: Emerging evidence highlights the significant role of Neutrophil Extracellular Traps (NET...

An integrative deep learning model based on dual-mode ultrasound for diagnosing gallbladder polyps.

OBJECTIVES: The aim of this study was to develop an artificial intelligence model to automatically d...

Interpretable MRI-Based Machine Learning Model for Noninvasive Prediction of Axillary Lymph Node Metastasis After Neoadjuvant Chemotherapy in Breast Cancer.

RATIONALE AND OBJECTIVES: Accurate prediction of axillary lymph node metastasis (ALNM) after neoadju...

Integrative Multiomics and Drug Sensitivity Profiling Reveal Potential Biomarkers and Therapeutic Strategies in Pediatric Solid Tumors.

UNLABELLED: Cure rates for childhood malignancies using established therapy protocols have increased...

Integrative Analysis of Multi-omic Pathways Predict Cancer-Affected Lobes in Lung Cancer.

Lung cancer is the leading cause of cancer-related deaths. The human microbiome plays an important r...

EXPRESS: Convolutional Autoencoder for Automated Pre-Processing of Tumor Cell and Tissue Raman Spectra.

Raman spectroscopy (RS) is a label-free, non-destructive optical modality that provides a detailed p...

SH3BP5L triggers the RAB11A-regulated integrin recycling network implicated in breast cancer metastasis.

Metastatic progression in aggressive breast cancer (BC) depends on a tightly controlled vesicular re...

Artificial Intelligence-Assisted Infrared Spectroscopy and Chemometrics for Enhanced Histopathology Screening of Micro- and Macrocancer Lesions.

Accurate detection of micro- and macrocancer lesions remains a critical challenge in histopathology,...

ASO Visual Abstract: Advancing Prognostics in Oncology: Developing a Machine Learning Model for Predicting 2-Year and 5-Year Survival Rates in Patients with Undifferentiated Pleomorphic Sarcoma.

Overcoming Resistance in EGFR-Mutant Cancers: A Comprehensive Review of Inhibitor Evolution and SAR-Based Design.

The epidermal growth factor receptor (EGFR) is a key target in cancer therapy, mainly in non-small c...

Multi-omics predicts radiotherapy response in small cell lung cancer patients receiving whole brain irradiation.

OBJECTIVE: Dosiomics and radiomics elaborate the low-and high-order features extracted from images t...

Minimal residual disease in solid tumors: Clinical applications and future directions.

Minimal residual disease (MRD) refers to the presence of residual cancer cells or tumor-derived frag...

The Immuno-Metabolic Crosstalk in Lung Squamous Cell Carcinoma: Prognostic Insights and Therapeutic Clues.

Lung squamous cell carcinoma (LUSC) has a poor prognosis due to the lack of effective targeted thera...

Comprehensive tumour-immune profiling reveals TREM2+ tumour-associated macrophages facilitating lymph node metastasis in head and neck squamous cell carcinoma.

BACKGROUND: Lymph node (LN) metastasis is a well-established independent prognostic factor in head a...

Targeted blood proteome profiling using NULISAseq identifies a high-performance biomarker panel for Aβ pathology quantification and staging.

INTRODUCTION: While current blood-based biomarkers for Alzheimer's disease (AD) are effective for de...

Pharmacokinetics and Customized Dosing of Vancomycin in Adult Patients With Hematological Malignancies: Status, Challenges, and Opportunities.

Vancomycin (VAN) remains the first-line treatment for methicillin-resistant, multidrug-resistant gra...

Intelligent multi omics and industry 6.0 and 7.0 enabled technologies for deciphering the tumor immune microenvironment and advancing cancer immunotherapy.

Recent advancements in cancer immunotherapy have transformed clinical oncology, with monoclonal anti...

A novel signature of palmitoylation for predicting prognosis and therapeutic response of hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) represents an extremely complex and heterogeneous malignant tumor. Pr...

Prediction of mortality, bleeding, and ischaemic events in patients with cancer and acute coronary syndrome: a model development and validation study.

BACKGROUND: Accurate assessment of mortality, bleeding, and atherothrombotic risk in patients with c...

ACACA modulates R-loop homeostasis to enhance lipid metabolism and microenvironmental interactions in ccRCC.

R-loops are dynamic nucleic acid structures implicated in genome regulation and instability, yet the...