Other Cancers

Recent advances in cancer nanomedicine: From smart targeting to personalized therapeutics - pioneering a new era in precision oncology.

Cancer nanomedicine has evolved from the 1995 landmark approval of Doxil® into a programmable platform of precision oncology. The field now progresses along a coherent continuum that begins with passive enhanced permeability and retention (EPR)-mediated tumor accumulation, advances to active ligand-receptor targeting, and culminates in stimuli-responsive carriers whose cargo is liberated only when...

Decoding strategies for enhancing immunotherapy in head and neck squamous cell carcinoma.

Immune checkpoint inhibitors have partially improved treatment outcomes for patients with head and neck squamous cell carcinoma (HNSCC), but the response rate remains low, with only a few patients benefiting. Mechanistically, HNSCC tumor cells often exhibit defects in antigen presentation, while the tumor microenvironment imposes multiple barriers that restrict immune cell infiltration. In additio...

PD-L1 expression combined with immune phenotype is a potential predictor of outcome with PD-1 inhibitor monotherapy in patients with recurrent or metastatic head and neck squamous cell carcinoma.

OBJECTIVE: Programmed cell death-ligand 1 (PD-L1) expression and immune phenotype (IP) are potential predictive biomarkers for immune checkpoint inhib...

CoREST complex inhibition alters RNA splicing to promote neoantigen expression and enhance tumor immunity.

Epigenetic macromolecular enzyme complexes tightly regulate gene expression at the chromatin level and have recently been found to colocalize with RNA...

Multimodal AI generates virtual population for tumor microenvironment modeling.

The tumor immune microenvironment (TIME) critically impacts cancer progression and immunotherapy response. Multiplex immunofluorescence (mIF) is a pow...

Advancements in the study of exosomes in disease diagnosis and treatment.

Exosomes are small, membrane-enclosed vesicles that can originate from a variety of sources and contain a wealth of material. They are involved in phy...

ChatGPT-4o as a diagnostic tool for skin cancer: Diagnostic accuracy in melanoma and non-melanoma detection.

INTRODUCTION: The global incidence of skin cancer is rising, emphasizing the need for early detection tools. Artificial intelligence (AI) models, incl...

Mri-based habitat and peritumoral radiomics for predicting the proliferative activity of stromal cells in giant cell tumor of bone.

PURPOSE: This study aims to explore the feasibility of MRI-based habitat and peritumoral radiomics for predicting the proliferative activity of stroma...

Immunocto: A massive immune cell database auto-generated for histopathology.

With the advent of novel cancer treatment options such as immunotherapy, studying the tumour immune micro-environment (TIME) is crucial to inform on p...

Stability control of metastable states as a unified mechanism for flexible temporal modulation in cognitive processing.

Flexible modulation of temporal dynamics in neural sequences underlies many cognitive processes. For instance, we can adaptively change the speed of m...

Profiling the Braak progression in Parkinson's disease: a transcriptomics and ML driven identification of progressive biomarker and prognostic ceRNA signature.

Parkinson's disease (PD), the second most prevalent neurodegenerative disorder, is marked by dopaminergic neuron loss and α-synuclein aggregation. Alt...

Attention-Guided Deep Learning of Chemical Exchange Saturation Transfer Magnetic Resonance Imaging to Differentiate Between Tumor Progression and Radiation Necrosis in Brain Metastasis.

PURPOSE: Stereotactic radiosurgery (SRS) is a standard treatment for brain metastases; however, it may lead to radiation necrosis (RN). RN can be virt...

Deep Learning for Differentiating Benign From Malignant Bile Duct Dilation on MRCP: Development and Prospective Evaluation of an Xception-Logistic Regression Ensemble Model.

BACKGROUND: Accurate identification of benign and malignant bile duct dilatation (BDD) is needed to determine its management plan. Conventional imagin...

Application of Machine learning in predicting cancer complications using longitudinal Data: A systematic review and Meta-Analysis.

Cancer prognosis of complications like metastasis, recurrence, and side effects of treatments is important to enhance patient prognosis. There is grea...

Emerging biomarkers in prostate cancer diagnosis and treatment: Insights into genetic, RNA and metabolic markers (Review).

Prostate cancer remains one of the most prevalent malignancies and a major cause of cancer‑related mortality among men worldwide. Despite widespread u...

Alternative splicing in cancer drug resistance: Mechanisms and therapeutic prospects (Review).

Alternative splicing (AS) is one of the principal mechanisms of post‑transcriptional regulation that confers transcriptomic plasticity and proteomic d...

Unraveling the microbiome's role in breast cancer progression and treatment response.

The human microbiome, encompassing microbial communities in the gut and breast tissue, has emerged as a critical modulator of breast cancer (BC) initi...

Development of a lactylation-related molecular classification and machine learning-based gene signature to predict survival, response to immunotherapy for ovarian cancer.

BACKGROUND: Lactylation is acknowledged as a regulator of numerous biological processes related to cancer. Research on the ability of lactylation-rela...

A comparative study of computer vision models for oral cancer detection from oral photographs.

BACKGROUND AND OBJECTIVE: Early detection of oral cavity cancers is critical for improving patient survival rates and treatment efficacy. In this cont...

Morphologic Evaluation of Hyperchromatic Crowded Groups Present in Cervical Thin Prep Cytology Tests as Identified by the Hologic Genius Digital Diagnostics System: A Descriptive Study.

BACKGROUND: Our descriptive study focused on morphologic characteristics of hyperchromatic crowded groups (HCGs) in ThinPrep cervical cytology tests w...