Other Cancers

Aspartame drives the continuous progression from MASLD to HCC.

BACKGROUND: Aspartame (APM), a widely used sweetener, has been linked to cancers, yet its molecular impact on metabolic dysfunction-associated steatotic liver disease (MASLD) and subsequent hepatocellular carcinoma (HCC) remains undefined. We integrated network toxicology, bulk RNA-seq and docking to map the mechanism. METHODS: APM targets were retrieved from ChEMBL, STITCH and SwissTargetPredicti...

Integrating stemness and epithelial-mesenchymal transition signatures with machine learning identifies RUNX1 as a therapeutic vulnerability in colorectal cancer.

Colorectal cancer (CC) arises from a complex interplay between genetic and epigenetic alterations within the colorectal mucosa, resulting in unchecked cellular proliferation and tumor development. This complexity results in diverse clinical presentations and varying responses to treatment, highlighting the critical need for personalized therapeutic approaches. The epithelial-mesenchymal transition...

Effects of Telerehabilitation Based on Motion Recognition Technology on Exercise Endurance of Patients With Non-Small Cell Lung Cancer After Surgery: Single-Center, Prospective, Open-Label, Randomized Controlled Trial.

BACKGROUND: Non-small cell lung cancer (NSCLC) accounts for approximately 85% of primary pulmonary neoplasms. Complete surgical removal remains the co...

Imaging the hallmarks of cancer.

The hallmarks of cancer were introduced by Hanahan and Weinberg as a conceptual organizing framework to distil the complexity of tumours. This concept...

Integrated multi-omics analysis reveals folate metabolism-related genes as prognostic markers and therapeutic targets in clear cell renal cell carcinoma.

BACKGROUND: Clear cell renal cell carcinoma (ccRCC) is an aggressive tumor with high metastatic potential and therapeutic resistance, yet the role of ...

Decoding glioblastoma evolution and heterogeneity through mechanistic modeling: implications for clinical translation.

Glioblastoma (GBM) is one of the most aggressive and lethal primary brain tumors in adults, characterized by dynamic clonal evolution and extensive ge...

Integrating artificial intelligence and multi-omics data for precision oncology in endometrial cancer: a narrative review.

Endometrial cancer (EC) is the most common gynaecological malignancy worldwide, yet the prognosis for advanced and recurrent disease remains poor, hig...

Exploring the application of Artificial Intelligence in palliative care and its practical, technical and ethical considerations: a scoping review.

BACKGROUND: Palliative care improves the quality of life of people living with life-limiting conditions and their families; however, global access rem...

Identification of distinct subgroups in Chinese patients with Behçet's syndrome via cluster analysis of immune cells and clinical features.

OBJECTIVES: This study aimed to use machine learning to explore Behçet's syndrome (BS) heterogeneity by integrating immunocyte subpopulations and clin...

Artificial Intelligence in Gynecologic Oncology: Current Applications, Clinical Challenges, and Future Perspectives.

Cervical, endometrial, ovarian, vulvar, vaginal, fallopian tube, and gestational trophoblastic neoplasia (GTN) are major gynecologic cancers that sign...

Deciphering the Therapeutic and Preventive Potential of Dietary Tannins in Osteosarcoma: A Multi-Omics Approach Targeting TGFA and Immune Microenvironment Remodeling.

Malignant tumors, including osteosarcoma (OS), are major non-communicable chronic diseases driven by systemic inflammation and oxidative stress. While...

Unveiling tumor heterogeneity by single cell RNA-sequencing: from basic considerations to clinical applications.

Tumor heterogeneity-encompassing diverse cellular phenotypes, genomic alterations, and micro-environmental contexts-is a principal barrier to effectiv...

Simulating the Dedifferentiation Process of Thyroid Cancer: Insights from Mouse Models and Ultrasound Imaging.

RATIONALE AND OBJECTIVE: Anaplastic thyroid carcinoma (ATC) may arise from the progression of differentiated thyroid cancers, but the mechanisms are n...

Engineering smart polymeric lipid nanoparticles for breast cancer: AI-guided formulation design, biological barriers, and translational constraints.

Breast cancer is a biologically heterogeneous disease in which tumor-intrinsic diversity and the tumor immune microenvironment jointly shape therapeut...

Elucidating the pathway activity and prognostic significance of diverse regulatory cell death patterns in pancreatic ductal adenocarcinoma.

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with a five-year survival rate below 10%. Regulatory cell death (RCD) plays ...

Pan-cancer analysis identifies immunoproteasome as the predominant survival-associated component of antigen processing machinery.

Neoantigens are critical targets for cancer immunotherapy, yet the relationship between experimentally validated neoantigen burden and antigen process...

TACE-induced liver injury in hepatocellular carcinoma: mechanisms, prediction, and prevention in the era of gut microbiota and inflammasome research.

Transarterial chemoembolization (TACE) is a cornerstone locoregional therapy for hepatocellular carcinoma (HCC), yet most candidates also have cirrhos...

MRI-based quantification of intratumoral heterogeneity for predicting recurrence risk in ER+/HER2- breast cancer.

OBJECTIVES: The need for a cost-effective, rapid, and increasingly accessible alternative to the 21-gene assay prompted this study, which developed a ...

CBINN: Cancer Biology-Informed Neural Network for Unknown Parameter Estimation and Missing Physics Identification.

The dynamics of tumor-immune interactions within a complex tumor microenvironment are typically modeled using a system of ordinary differential equati...

Multi-cohort integration and machine learning identify CPVL as a novel oncogenic driver in gastric cancer.

BACKGROUND: Gastric cancer (GC) remains a leading cause of cancer-related mortality worldwide, and the prognosis of advanced GC remains poor. Systemat...