Other Cancers

Optimizing Treatment for Depression in Primary Care Using Psychotherapy Versus Antidepressant Medication in a Low-Resource Setting: Protocol for the OptimizeD Randomized Controlled Trial.

Psychotherapy and antidepressant medications are first-line treatments for depression, and they both have significant treatment effects on average. However, treatment response varies widely across patients, and neither approach is universally effective. Identifying the most effective treatment for each patient is critical everywhere, but particularly in low-resource settings where access to menta...

Enhancing Label-Free Fluorescence Lifetime Imaging for Intraoperative Tumor Margin Delineation in Head and Neck Cancer using Data-Centric AI.

Precise intraoperative delineation of tumor margin is critical for maximizing resection completeness and minimizing recurrence in head and neck cancers (HNC). Label-free Fluorescence Lifetime Imaging (FLIm), which captures the fluorescence decay characteristics of endogenous molecules, offers a real-time method for differentiating malignant from healthy tissue during surgery without the need of co...

Multiscale analysis and optimal glioma therapeutic candidate discovery using the CANDO platform.

Glioma is a highly malignant brain tumor with limited treatment options. We employed the Computational Analysis of Novel Drug Opportunities (CANDO) pl...

Liquid Biopsy: The Challenges of a Revolutionary Approach in Oncology.

Liquid biopsy has gained attention in oncology as a non-invasive diagnostic tool, offering valuable insights into tumor biology through the analysis o...

Immune-related gene risk model establishment and role of key gene FUCA1 in malignant pleural mesothelioma.

BACKGROUND: Malignant pleural mesothelioma (MPM) is a rare type of tumor closely associated with asbestos exposure. Increasing evidence shows that hig...

Construction of a predictive model for relapse of primary autoimmune hemolytic anemia: a retrospective cohort study.

OBJECTIVES: To develop a machine learning-based model to predict the relapse risk of Primary Autoimmune Haemolytic Anaemia (AIHA) after the last remis...

Optical coherence tomography angiography as a tool for diagnosis and monitoring of sickle cell related eye disease: a systematic review and meta-analysis.

Sickle cell retinopathy (SCR) is an ocular manifestation of sickle cell disease (SCD). In SCR abnormal sickling of erythrocytes is associated with sig...

Deep learning dosiomics for the pretreatment prediction of radiation dermatitis in nasopharyngeal carcinoma patients treated with radiotherapy.

PURPOSE: To develop a combined dosiomics and deep learning (DL) model for predicting radiation dermatitis (RD) of grade ≥ 2 in patients with nasophary...

Deep-learning-enabled multi-omics analyses for prediction of future metastasis in cancer.

Metastasis remains the leading cause of cancer-related mortality, yet predicting future metastasis is a major clinical challenge due to the lack of va...

Plasma and Urine Circulating Tumor DNA Methylation Profiles for Non-Invasive Pancreatic Ductal Adenocarcinoma Detection: Significant Findings in Plasma Only.

Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy with limited treatment options, and early detection remains challenging due to the lack...

Development of Explainable Machine Learning Models to Identify Patients at Risk for 1-Year Mortality and New Distant Metastases Postendoprosthetic Reconstruction for Lower Extremity Bone Tumors: A Secondary Analysis of the PARITY Trial.

BACKGROUND: Accurate prediction of postoperative metastasis and mortality risks in patients undergoing lower-limb oncological resection and endoprosth...

Multi-omics and single-cell approaches reveal molecular subtypes and key cell interactions in hepatocellular carcinoma.

INTRODUCTION: Hepatocellular carcinoma is a highly aggressive and heterogeneous malignancy with limited understanding of its heterogeneity.

Single-cell and bulk transcriptome analyses reveal elevated amino acid metabolism promoting tumor-directed immune evasion in colorectal cancer.

INTRODUCTION: Colorectal cancer (CRC), the third most common cancer worldwide, often shows limited responsiveness to immunotherapy due to its predomin...

Metabolic profiles in laryngeal cancer defined two distinct molecular subtypes with divergent prognoses.

BACKGROUND: Laryngeal cancer (LCA) is the second most common type of head and neck malignancy, characterized by high recurrence rates and poor overall...

Immunopeptidomics-guided discovery and characterization of neoantigens for personalized cancer immunotherapy.

Neoantigens have emerged as ideal targets for personalized cancer immunotherapy. We depict the pan-cancer peptide atlas by comprehensively collecting ...

Computational analysis of DEHP's oncogenic role in colorectal cancer.

BACKGROUND: Colorectal cancer (CRC) remains a leading cause of cancer-related mortality globally, with many patients diagnosed at advanced stages. Cur...

Metabolic reprogramming and immune microenvironment profiling in clear cell renal cell carcinoma: implications for prognosis, targeted therapy, and drug resistance.

Clear cell renal cell carcinoma (ccRCC) is the most prevalent form of kidney cancer, distinguished by intricate interactions between metabolic reprogr...

DeepCCDS: Interpretable Deep Learning Framework for Predicting Cancer Cell Drug Sensitivity through Characterizing Cancer Driver Signals.

Accurate characterization of cellular states is the foundation for precise prediction of drug sensitivity in cancer cell lines, which in turn is funda...

Lung MRI: Indications, Capabilities, and Techniques- Expert Panel Narrative Review.

Lung MRI provides both structural and functional information across a spectrum of parenchymal and airway pathologies. MRI, using current widely availa...

Arginine methylation patterns in LUAD: defining prognostic subtypes and relevance to immunotherapy.

BACKGROUND: Lung cancer remains the leading cause of cancer-related death worldwide, with lung adenocarcinoma (LUAD) being the most common subtype. Ar...