Other Cancers

Exploratory Comparison of Meld, Meld-Na, and Meld 3.0 Scores for Prognostic Assessment at Diagnosis in Hepatocellular Carcinoma Using Machine Learning Approaches.

BACKGROUND: Hepatocellular carcinoma (HCC) is the most common primary liver tumor. Despite efforts to mitigate risk factors and implement surveillance programs in high-risk populations, such as screening, these strategies alone appear insufficient to significantly improve prognosis at diagnosis. The identification of novel prognostic factors remains an underdeveloped field that may play a key role...

Screening of the key gene PAMR1 in breast cancer and its immunological and pharmacogenomic characteristics.

Breast cancer (BC) is a highly heterogeneous malignancy with a complex pathogenesis involving multiple molecular pathways and cellular interactions. The tumor microenvironment (TME) plays a crucial role in this process, but the functions of immune and stromal components within the TME remain to be further elucidated. This study aims to identify core genes associated with differential expression an...

Deep learning-based cervical cancer T-staging using MRI: multi-structure segmentation and classification.

AIMS: Cervical cancer has high incidence and mortality, seriously threatening women's survival and quality of life. Radiologists currently rely mainly...

What's next for VI-RADS? Updates and future perspectives from the ACR VI-RADS steering committee.

Since the introduction of the Vesical Imaging-Reporting and Data System (VI-RADS), MRI has become an important imaging modality in the management of p...

ABCC2 as a novel therapeutic target in lung adenocarcinoma: a machine learning-driven discovery linking ammonia metabolism to prognosis and drug resistance.

BACKGROUND: Ammonia, long regarded as a metabolic waste product, has recently been recognized as a pivotal oncometabolite in the tumor microenvironmen...

Decoding the microbiome: artificial intelligence-targeted gut microenvironment breakthroughs in personalized cancer therapy.

The gut microbiome functions as a key regulator of tumorigenesis and progression, thereby modulating tumor development and treatment outcomes (includi...

FOSL2 drives transcriptional activation of super‑enhancer-regulated DYNC1H1 to promote hypoxia‑induced oral squamous cell carcinoma progression.

Hypoxia is a hallmark of oral squamous cell carcinoma (OSCC) and plays a critical role in driving tumor progression. However, the mechanisms by which ...

From Technological Innovation to Clinical Translation: Progress and Challenges in 3D Bioprinting for the Development of Breast Cancer Bone Metastasis Models.

The construction of 3D in vitro tumor models centered on bioprinting technology represents one of the most anticipated interdisciplinary innovations a...

Two-stage deep learning networks for diagnosing and staging membranous glomerulonephritis from electron microscopy images.

PURPOSE: The purpose of this study was to use transmission electron miscroscopy images to develop a deep-learning-based artificial intelligence model ...

Deep Learning-Based Diagnosis of Parotid Gland Tumors on CT Images: A Multi-view Approach for Preoperative Differentiation of Benign and Malignant Lesions.

BACKGROUND: Accurate preoperative differentiation between benign and malignant parotid gland tumors is essential for guiding surgical planning and tre...

Artificial Intelligence for Sleep Instability and Motor Phenotyping: Clinical Translation Beyond Sleep Staging.

Sleep medicine has rapidly adopted artificial intelligence, but most applications still prioritize automated sleep staging or single summary indices, ...

AI-MIRACLE: Artificial Intelligence and MultIpaRAmetric MRI Predict CLinical OutcomEs to Neoadjuvant Immunotherapy in Patients with Muscle-invasive Bladder Cancer Undergoing Radical Cystectomy.

BACKGROUND AND OBJECTIVE: Neoadjuvant immune-checkpoint inhibitors (ICIs) in muscle-invasive bladder cancer (MIBC) were tested in patient's ineligible...

Machine learning based approaches for structure activity relationship analysis of heparanase inhibitors.

Human Heparanase (HPSE), the only mammalian endo-β-D-glucuronidase, plays an important role in extracellular matrix remodeling and the release of hepa...

A multimodal interpretable deep learning-radiomics framework for predicting lymph node metastasis following neoadjuvant chemoradiotherapy in locally advanced rectal cancer: a multicenter validation study.

Accurate assessment of lymph node metastasis (LNM) following neoadjuvant chemoradiotherapy (nCRT) presents a significant clinical challenge and is ess...

Cyclosporine in hematological disorders: mechanisms, clinical practice and emerging advances.

Cyclosporine A (CsA) functions as a calcineurin inhibitor that perturbs T cell activation via calcineurin-nuclear factor of activated T cells (CaN-NFA...

Exercise-related genes predicts overall survival and tumor immune microenvironment, and identifies the biological role of SLC52A2 in breast cancer.

BACKGROUND: Breast cancer (BRCA) is the most common malignant tumor in women, with prognoses differing markedly by molecular subtype. Exercise is know...

A novel prognostic model based on MVIRGs identifies ANGPT2 as a key target driving the malignant progression of HCC.

BACKGROUND: Hepatocellular carcinoma (HCC) is a highly lethal malignancy with high recurrence and limited therapies. Microvascular invasion (MVI) is a...

MSTM-Net: a two-stage prostate cancer segmentation network based on swin-transformer-mamba architecture.

BACKGROUND: Magnetic resonance imaging (MRI) has become a core imaging modality for prostate cancer screening and diagnosis. Accurate and automatic se...

Network toxicology and bioinformatics reveal potential molecular links between cadmium exposure and pancreatic cancer.

BACKGROUND: Environmental cadmium (Cd) pollution poses a severe threat to human health due to its strong bioaccumulation and high carcinogenicity. Alt...

DNA damage response signature-based prognostic genes for intrahepatic cholangiocarcinoma: a combined analysis of machine learning and biological experiments.

BACKGROUND: Intrahepatic cholangiocarcinoma (ICC) is a highly aggressive subtype of primary liver cancer with insidious onset, early metastasis, and p...