Other Cancers

Identification of key genes associated with T cell exhaustion in HIV infection based on transcriptomic data.

BACKGROUND: Human immunodeficiency virus (HIV) is a lentivirus belonging to the retrovirus subclass. HIV specifically targets and infects human CD4 + T lymphocytes, and T cell exhaustion (TEX) plays an important role in disease progression. However, the specific molecular mechanisms have not been fully elucidated. In this study, we explored the potential mechanisms by analyzing transcriptomic data...

Epigenetic editing approaches maturity: AI-driven precision design, delivery innovation, and the road to clinical translation.

Epigenetic editing achieves durable gene silencing through targeted modification of chromatin and DNA methylation states without altering the genomic sequence-modifications that remain fundamentally reversible compared with genome editing. Long constrained by transient efficacy, insufficient precision, and delivery bottlenecks, the field reached a critical inflection point in 2024-2025, measurable...

AI-Optimized 3D-Printed Dual-Layer Implant: Resolving Chemo-Immunotherapy Sequential Administration Dilemma for Colorectal Cancer Peritoneal Metastasis.

The synergistic integration of chemotherapy and immunotherapy represents the most promising strategy for enhancing therapeutic efficacy in cancer trea...

Genomic profiling as an option for ovarian cancer diagnostics.

INTRODUCTION: Ovarian cancer (OC) is a highly heterogeneous and lethal gynecological malignancy. Precision oncology has shifted the management paradig...

Colorectal Cancer Screening in Hereditary and Familial High-Risk Populations: Best Practices and Future Directions.

Colorectal cancer (CRC) remains a leading cause of cancer-related morbidity and mortality worldwide yet is largely preventable through effective scree...

Recurrence of Basal Cell Carcinoma across Different Treatment Modalities: A Nationwide Study with 8 Years of Follow-up and Modelled Prediction.

Despite the rising incidence of basal cell carcinoma (BCC), few studies have compared treatment outcomes or predicted recurrences using nationwide rea...

Development of a prediction model for recurrence in patients with malignant ovarian germ cell tumors undergoing fertility-sparing surgery: A multicenter retrospective study.

OBJECTIVE: To investigate the clinical characteristics associated with recurrence in malignant ovarian germ cell tumors (MOGCT) patients who received ...

Evaluating human-AI interaction in optical diagnosis of early colorectal carcinoma through endoscopist responses to simulated artificial intelligence: a multinational online study.

Background Suboptimal human - artificial intelligence (AI) interaction is a potential roadblock for implementation of AI in clinical practice. We aime...

ASTHMA AT THE CROSSROADS: FROM ANTI-TNF-α SETBACKS TO NEXT-GENERATION BIOLOGICS TARGETING TYPE 1 AND TYPE 2 INFLAMMATION.

Severe asthma remains a major unmet clinical challenge due to its marked immunological heterogeneity and the limited efficacy of current therapies in ...

A deep learning model to predict objective response to TACE and TKI-based therapy in HBV-related uHCC.

TACE and TKI-based combination therapy shows promise for unresectable hepatocellular carcinoma (uHCC), but inter-patient heterogeneity requires reliab...

Deep learning-based classifier for malignant plasma cell identification in myeloma.

Multiple myeloma (MM) displays significant genetic heterogeneity, making it challenging to distinguish malignant from non-malignant plasma cells in si...

Automated identification of keratinocyte cancers in pathology reports using large language models.

Keratinocyte cancers (KCs) are the most prevalent cancers in white-skinned individuals, yet remain underrepresented in cancer registries because repor...

Integrative profiling of senescence-associated cells and genes identifies UGT1A7 as a prognostic and therapeutic target in Lung squamous cell carcinoma.

Lung Squamous Cell Carcinoma (LUSC), a common subtype of non-small cell lung cancer, primarily occurs in elderly individuals and is closely linked to ...

Multi-regional radiomics based on planning CT and information complementarity between GTVp and GTVn: an explainable model for predicting 5-year recurrence risk in HPV-positive oropharyngeal cancer.

PURPOSE: This study aims to develop and validate a multi-regional radiomics machine learning model integrating the spatial heterogeneity features of b...

Preoperative prediction of occult high-volume central lymph node metastasis in clinically node-negative papillary thyroid carcinoma using a multimodal practical model: development, temporal validation, and external validation.

PURPOSE: Preoperative risk estimation of occult high-volume central lymph node metastasis (CLNM) in clinically node-negative (cN0) papillary thyroid c...

Celldetective, an AI-enhanced image analysis tool for unraveling dynamic cell interactions.

Analysis of multimodal and multidimensional data capturing dynamic interactions between diverse cell populations is a current challenge in bioimaging,...

Spiky Magnetic Titania Particles for Integrated Exosome Capture and Metabolic Profiling Toward Cancer Diagnosis.

Exosomal metabolite profiling represents a promising non-invasive approach for cancer diagnosis. However, its widespread application has been constrai...

Virus infections and cancers: from mechanisms to therapeutics.

Viral infections are a major contributor to global cancer incidence and mortality. However, integrative reviews that connect viral classification, car...

Macrophage-Induced Senescent Cancer-Associated Fibroblasts Promote SASP-Mediated Chemoresistance in Colorectal Cancer.

Cancer-associated fibroblasts (CAFs) play a crucial role in the tumor microenvironment (TME) by influencing tumor progression, metastasis, and therapy...

Astragalus polysaccharide-based thermoresponsive hydrogel loaded with β-elemene nanoemulsion in combination with anti-PD-L1 therapy for triple-negative breast cancer.

Triple-negative breast cancer (TNBC) is classified as an immunologically cold tumor, which markedly weakens the therapeutic efficacy of immune checkpo...