Other Cancers

Artificial Intelligence for Predicting Treatment Response in Patients With Anxiety Disorders After Cognitive Behavioral Therapy: Systematic Review and Meta-Analysis.

BACKGROUND: Artificial intelligence (AI) models have been increasingly explored for predicting treatment response to cognitive behavioral therapy (CBT) in patients with anxiety disorders. Identifying potential responders in advance may help inform treatment planning and support clinical decision-making. Although a growing number of studies have applied AI techniques in this context, reported perfo...

Token-guided multimodal prognosis in hepatocellular carcinoma: a framework steered by tumour-stroma ratio.

BACKGROUND: The tumour-stroma ratio (TSR) is a potential prognostic indicator, yet hindered by quantification challenges and conflicting reports. OBJECTIVE: To determine whether TSR follows a non-linear prognostic pattern and to develop an artificial intelligence (AI)-powered framework for standardised TSR assessment and prognosis prediction in hepatocellular carcinoma (HCC). DESIGN: We integrated...

dMMR prediction from colorectal cancer histopathology: Leveraging non-tumor and low-magnification regions.

BACKGROUND AND OBJECTIVE: Colorectal cancer is the second leading cause of cancer-related mortality worldwide, posing a substantial burden on healthca...

LymphUs: A multicenter open-access database of lymph node ultrasound images in patients with papillary thyroid carcinoma for clinical and artificial intelligence research.

Approximately 30-50% of Papillary thyroid carcinoma (PTC) patients develop cervical lymph nodes (LNs) metastasis, significantly increasing the risk of...

A generative explainable model for antimicrobial peptide prediction using bidirectional temporal convolutional neural network.

Advances in artificial intelligence (AI) and multi-omics integration are reshaping precision oncology by enabling deeper mechanistic understanding, im...

Signs and symptoms indicating the transition to the palliative phase in patients with COPD and heart failure in primary healthcare: a mixed-methods study.

The pre-metastatic niche: mechanisms, heterogeneity, and therapeutic opportunities.

Metastasis remains the leading cause of cancer-related mortality. The concept of the pre-metastatic niche (PMN) has provided a new framework for under...

Unraveling the diagnostic and prognostic signatures of oral microbiota in head and neck cancer.

BACKGROUND: Head and neck cancer, predominantly squamous cell carcinoma, has emerged as a significant global health concern. Growing evidence has esta...

A genetically optimized physics-informed neural network for multiphysics modeling of magnetic hyperthermia in brain cancer.

Magnetic hyperthermia therapy (MHT) in glioblastoma requires accurate modeling of nanoparticle transport and heat deposition across highly heterogeneo...

Decoding the immune-tumor synapse for data-driven design of next-generation immunotherapies.

The immunological synapse (IS) formed between cytotoxic CD8+ T lymphocytes (CTLs) and tumor cells represents the critical interface where many immunot...

Tumor organoids on-a-chip and the role of AI in predictive oncology and personalized cancer medicine.

The drug development process in cancer faces significant challenges due to high failure rates in translational studies despite promisingin vitroresult...

Immune checkpoint molecules beyond PD-1 and CTLA-4: emerging targets in autoimmune diseases and cancer immunotherapy.

BACKGROUND: Immune checkpoint molecules are pivotal regulators of immune activation and tolerance, playing critical roles in cancer, autoimmunity, inf...

Unsupervised clustering analysis unravels the role of systemic inflammatory indices in the prognosis of patients with locally advanced cervical cancer treated with chemoradiation.

BACKGROUND AND PURPOSE: This study aimed to predict the treatment outcomes and survival of patients with locally advanced cervical cancer (LACC) recei...

Application value of gastric contrast ultrasonography in gastric tumors.

In recent years, gastric oral contrast ultrasonography (OCUS) and double contrast-enhanced ultrasonography (DCEUS) have emerged as promising imaging t...

Molecular and Pharmacogenetic Marker Evaluation in Relation to the Toxicity and Clinical Response of Acute Lymphoblastic Leukemia Treatment in Indian Children (MPGx-INDALL): Protocol for a Prospective Observational Cohort Study.

BACKGROUND: Understanding interindividual variability in treatment response and toxicity is essential for optimizing outcomes in pediatric acute lymph...

Development and validation of machine learning prognostic models for overall survival in non-surgical prostate cancer patients with bone metastases.

OBJECTIVE: To construct and interpret a machine learning model for predicting overall survival in nonsurgical prostate cancer with bone metastases (PC...

Ganglioside-Mediated Neural-Acinar Crosstalk Facilitates Pancreatic Carcinogenesis via Metaplastic Niche Remodeling.

BACKGROUND & AIMS: Neural networks constitute a crucial component of the tumor microenvironment that remains underexplored in pancreatic carcinogenesi...

Twisted Tapestry of Tumors: Updates in Molecular Pathology of Breast Tumors.

This article explores the expanding role of molecular diagnostics in breast pathology. It emphasizes how immunohistochemistry, fluorescence in situ hy...

Peritumoral habitat radiomics predicts axillary lymph node metastasis in breast cancer.

Accurate preoperative prediction of axillary lymph node metastasis (ALNM) is critical for personalized management of breast cancer. Here, we developed...

Anharmonic Thermodynamics Redefines Metastability and Parent Phases in Ferroelectric HfO2.

Hafnia (HfO2) is a silicon-compatible dielectric material, yet stabilizing its desired but metastable ferroelectric phase remains challenging. Phase s...