Pain Management

Latest AI and machine learning research in pain management for healthcare professionals.

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Proteomic signatures of APOE ε4 across human tissues and cell types in Alzheimers disease

The apolipoprotein E {varepsilon}4 (APOE {varepsilon}4) allele is the strongest genetic risk factor for late-onset Alzheimers disease (AD). However, the underlying molecular mechanisms remain unclear. This study included 1691 participants from the Religious Orders Study and Rush Memory and Aging Project (ROSMAP), 1226 participants from the Accelerating Medicines Partnership - Alzheimers Disease (A...

Characterizing the landscape of gene process dependencies in cancer

Precision oncology aims to tailor cancer treatment to tumor genetics but it currently benefits only a small fraction of patients, in part because the primary focus is to match drug targets to single genes. The Cancer Dependency Map Project (DepMap) aimed to characterize the landscape of single-gene dependencies, which increased the universe of potential drug targets. However, the common challenges...

TAME: Temporal-Aware Mixture-of-Experts for Text-Video Retrieval

Text-Video Retrieval (TVR) retrieves videos that match a natural-language query, but extending image-text models such as CLIP to videos is fundamental...

Sep 2 2026 2609.02204v1
CREST: A Cortical Resting-State EEG Spatial Transformer for Chronic Pain Inference

Chronic pain mechanisms are complex, spanning multiple brain regions and networks. We ask whether resting brain activity carries a readout of that sta...

Oligodendrocyte Enriched Brain Organoids Reveal Impaired Oligodendroglial Maturation and Altered Neural Network Activity in Down Syndrome

Individuals with Down syndrome (DS) display developmental delay, intellectual disability, premature brain ageing, and an increased risk of Alzheimer-l...

Differential Associations of Microglial Inflammation on LATE-NC and Tangle-Related Hippocampal Atrophy

BACKGROUND: Accumulations of AD and LATE-NC both contribute to changes in hippocampal volume, possibly via distinct and/or overlapping mechanisms. Mic...

Order Matters: A Chinese Multi-Panel Meme Benchmark for Vision-Language Reasoning

Many multimodal tasks depend on how visual elements are ordered and composed, not only on recognizing them in isolation. Internet memes are a compact ...

Aug 27 2026 2608.26866v2
Order Matters: A Chinese Multi-Panel Meme Benchmark for Vision-Language Reasoning

Many multimodal tasks depend on how visual elements are ordered and composed, not only on recognizing them in isolation. Internet memes are a compact ...

Aug 27 2026 2608.26866v1
Graph-Based Pseudo-multimodal Contrastive Learning for 12-Lead ECG Representations

12-lead electrocardiogram (ECG) is a standard, non-invasive examination widely used for diagnosing coronary artery disease, where clinical interpretat...

Aug 27 2026 2608.26964v1
Mapping Alzheimer's neuropathology signatures to the whole brain transcriptome using machine learning data fusion

In Alzheimer's disease (AD), misfolded proteins emerge across the entire brain in structured, yet not rigid, spatiotemporal patterns. Yet, a systemati...

TEAMS: Text-prompted spatiotEmporal dual-heAd Mamba Snake

Deep snake is a promising family of instance segmentation methods that accurately predicts object-level contours, thereby overcoming common pixel-leve...

Aug 18 2026 2608.17421v1
3D Weighted Geometric Graph Neural Networks for Sheep Facial Pain Assessment

Deep learning systems perform mainly within the 2D for a single image domain and take the face as a single-dimension representation, losing sight of t...

Aug 11 2026 2608.11050v1
CircuitReason-1k: Benchmarking Long-Horizon Visual-to-Symbolic Reasoning inElectrical Circuits

Electrical circuit analysis requires more than recognizing components in an image. A solver must ground symbols and labels, recover latent topology, s...

Aug 10 2026 2608.09374v1
SpSYRK: Half the Work in Distributed Sparse Matrix Multiplication

The symmetric rank-$k$ update (SYRK), $\C = \A\A^\top$, computes the dot product between each pair of rows of $\A$, producing the Gram matrix $\C$. It...

Aug 10 2026 2608.09713v1
CDGC-Net: 3D Medical Image Segmentation with Cooperative Dual-Scale Self-Attention and Grouped Channel Modeling

Accurate 3D medical image segmentation requires the integration of long-range anatomical context with fine boundary detail. Existing methods often mod...

Aug 9 2026 2608.08575v1
The Illusion of Understanding: A Randomized Controlled Trial of LLM-Generated Lay Summaries of Brain MRI Reports

Background: Large language models have been proposed to improve patient comprehension of radiology reports. However, whether they improve objective un...

LabGrymace: Automated Analysis of Mouse Grimace for Quantitative Assessment of Pain Dynamics

Accurate assessment of pain in animal models is essential for understanding pain mechanisms, developing analgesics, and ensuring animal welfare. The M...

ECHO: A Locally-Deployable Agentic Health Assistant with Temporal Memory, Safety Guardrails, and Speech Assessment

This paper presents ECHO (Enhanced Care \& Health Observer), a locally-deployable conversational health assistant for long-term chronic care managemen...

Aug 6 2026 2608.06110v1
Enhancing Low Back Pain Assessment with Diffusion Models for Lumbar Spine MRI Segmentation

This study introduces a diffusion-based framework for robust and accurate semantic segmentation of lumbar spine MRI scans from patients with low back ...

Aug 5 2026 2608.04906v1
A Comparative Study of Feature Selection Methods for EHR Diagnosis Codes in Opioid Use Disorder Prediction

Feature selection is a critical step in electronic health record (EHR)-based predictive modeling, where input variables are often high-dimensional, sp...

Aug 4 2026 2608.04180v1
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