Pain Management

Latest AI and machine learning research in pain management for healthcare professionals.

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Multiplex Proteomics of Lewy Body Dementia Reveals Cerebrospinal Fluid Biomarkers of Clinical and Neuropathological Heterogeneity

Lewy body dementia (LBD), which encompasses Parkinson's disease dementia (PDD) and Dementia with Lewy bodies (DLB), lacks established biofluid markers of its complex clinical and neuropathological heterogeneity. Multiplex proteomic tools, such as the recently developed NUcleic acid Linked ImmunoSandwich Assay (NULISA), can assess a diverse array of neurodegenerative targets and address these bioma...

SeGA-GNN: Semantically Gated Augmented Graph Neural Networks for Wearable-Based Emotion Detection

Background: Wearable technologies enable scalable and continuous monitoring of emotional states through passive sensing of physiological and behavioral signals. However, conventional learning approaches often struggle to model the complex temporal, contextual, and relational dependencies underlying human emotions. To address these limitations, we propose a graph-based framework that represents mul...

Stigmatizing Language Detection in Opioid Use Disorder Patient-Directed Discharge Clinical Documentation: A Privacy-Preserving Analysis Using a Locally Deployed Large Language Model

Objective: Stigmatizing language in the electronic health record (EHR) has been associated with adverse patient experience in substance use disorder c...

Personalized Brain-Based Analgesia Detection with Portable fNIRS and AI

Neuroimaging based pain decoding faces two underappreciated challenges: between subject variability that prevents classifiers from generalizing across...

Phylogenetically Dispersed Subsetting for Species-Level Machine Learning Evaluation: Dependence-Aware Validation and Limited Effective Information

Machine learning is increasingly applied to species-level biological data, but phylogenetic autocorrelation can make evaluation species statistically ...

A Multimodal Framework for Dementia Detection via Linguistic and Acoustic Representation Learning

Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the leading cause of dementia, affecting memory, reasoning, communication, an...

May 25 2026 2605.25540v1
Context-driven Missing-Modality Learning for Robust Medical Diagnosis with Image-Tabular Data

While multimodal data integrating diverse imaging and clinical tabular records is crucial for accurate medical diagnosis, the arbitrary absence of spe...

May 25 2026 2605.25968v1
Multi-view Consistent 3D Gaussian Head Avatars 'without' Multi-view Generation

High-fidelity 3D Gaussian head avatar generation is critical for applications such as AR/VR, telepresence, and digital humans. Existing methods depend...

May 24 2026 2605.25220v1
Predicting Autopsy-Confirmed Neuropathology across Clinical, Neuroimaging, and CSF Biomarkers using Machine Learning

Accurate in vivo prediction of neuropathology is critical for advancing diagnosis and treatment of Alzheimer's disease and related dementias (ADRDs). ...

MASHA: A Multi-Agent System for Healthcare Sentiment Analysis Using AI for Migraine Detection in Arabic Tweets

Migraine detection and sentiment analysis in healthcare have become increasingly important, particularly with the rise of social media platforms like ...

A Competitive Framework for Modeling EEG Microstate Durations

Background. This study examines a competition based model (Cmodel) designed to capture the temporal dynamics of successive brain microstates derived f...

Post-ED Trajectory Prediction in Abdominal Pain with a Generative Medical Event Model

Importance: Abdominal pain causes roughly 10 million US emergency department (ED) visits annually, most resulting in discharge. Post-discharge courses...

Gut microbiota signatures differentiate trajectory-defined response phenotypes and predict self-management outcomes in irritable bowel syndrome

Background: Heterogeneity in symptom presentation and treatment response in irritable bowel syndrome (IBS) remains poorly understood. The gut microbio...

Widespread use of invalid statistical tests in biomedical machine learning

Machine learning is accelerating biomedical research. Cross-validation is widely used to compare predictive performance -- not only to benchmark algor...

Modeling Complex Effects and Individual Variability in Multi-Paradigm fMRI with Nonlinear Mixed Models

Functional magnetic resonance imaging (fMRI) data are inherently complex, characterized by high dimensionality, intricate inter-regional dependencies,...

Transcript architecture predetermines m6A remodeling and sensory neuron vulnerability in chemotherapy-induced peripheral neuropathy

Whether individual transcripts carry intrinsic features that predetermine their response to external perturbations is unknown. Here we used nanopore d...

Artificial intelligence-generated digital Romberg test for peripheral neuropathy monitoring.

Background and Objectives Patients with peripheral neuropathies (PN) commonly exhibit balance impairment. In clinical practice, balance is typically a...

AIM-DDI: A Model-Agnostic Multimodal Integration Module for Drug-Drug Interaction Prediction

Drug-drug interaction (DDI) prediction is a critical task in computational biomedicine, as adverse interactions between co-administered drugs can caus...

May 14 2026 2605.14327v1
SceneForge: Structured World Supervision from 3D Interventions

Many multimodal learning tasks require supervision that remains consistent across edits, viewpoints, and scene-level interventions. However, such supe...

May 14 2026 2605.14399v1
CAWI: Copula-Aligned Weight Initialization for Randomized Neural Networks

Randomized neural networks (RdNNs) enable efficient, backpropagation-free training by freezing randomly initialized input-to-hidden weights, which per...

May 12 2026 2605.12580v1
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