Pain Management

Latest AI and machine learning research in pain management for healthcare professionals.

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VFGS-Net: Frequency-Guided State-Space Learning for Topology-Preserving Retinal Vessel Segmentation

Accurate retinal vessel segmentation is a critical prerequisite for quantitative analysis of retinal images and computer-aided diagnosis of vascular diseases such as diabetic retinopathy. However, the elongated morphology, wide scale variation, and low contrast of retinal vessels pose significant challenges for existing methods, making it difficult to simultaneously preserve fine capillaries and m...

Feb 11 2026 2602.10978v1

Multi-objective computational design optimization of a Total Disc Replacement implant

While cervical arthroplasty using Total Disc Replacement (TDR) implants is an established treatment for persistent neck and arm pain, revision rates limit it from reaching its full potential. To address the underlying complications, we developed finite element simulation-driven design optimizations for a TDR's bone-implant interface and motion-preservation features. These automated processes explo...

Feb 10 2026 2602.10304v1
Efficient Brain Extraction of MRI Scans with Mild to Moderate Neuropathology

Skull stripping magnetic resonance images (MRI) of the human brain is an important process in many image processing techniques, such as automatic segm...

Feb 9 2026 2602.08764v1
ChatUMM: Robust Context Tracking for Conversational Interleaved Generation

Unified multimodal models (UMMs) have achieved remarkable progress yet remain constrained by a single-turn interaction paradigm, effectively functioni...

Feb 6 2026 2602.06442v1
DiTS: Multimodal Diffusion Transformers Are Time Series Forecasters

While generative modeling on time series facilitates more capable and flexible probabilistic forecasting, existing generative time series models do no...

Feb 6 2026 2602.06597v1
Single-cell machine learning uncovers genetically anchored, cell-type specific programs of Alzheimer's disease

Aging and genetic risk shape the molecular programs that confer cellular vulnerability in Alzheimer's disease (AD), but whether these programs differ ...

DSXFormer: Dual-Pooling Spectral Squeeze-Expansion and Dynamic Context Attention Transformer for Hyperspectral Image Classification

Hyperspectral image classification (HSIC) is a challenging task due to high spectral dimensionality, complex spectral-spatial correlations, and limite...

Feb 2 2026 2602.01906v1
Organellomics: AI-driven deep organellar phenotyping reveals novel ALS mechanisms in human neurons

Systematic assessment of organelle architectures, termed the organellome, offers valuable insights into cellular states and pathomechanisms, but remai...

Individual Differences in Dopaminergic Modulation of Exploration-Exploitation Behaviour

Dopamine (DA) has been implicated in exploration-exploitation behaviour, i.e., exploring novel, potentiallybetter options vs. exploiting known, previo...

User-Adaptive Meta-Learning for Cold-Start Medication Recommendation with Uncertainty Filtering

Large-scale Electronic Health Record (EHR) databases have become indispensable in supporting clinical decision-making through data-driven treatment re...

Jan 30 2026 2601.22820v1
NativeTok: Native Visual Tokenization for Improved Image Generation

VQ-based image generation typically follows a two-stage pipeline: a tokenizer encodes images into discrete tokens, and a generative model learns their...

Jan 30 2026 2601.22837v1
On Safer Reinforcement Learning Policies for Sedation and Analgesia in Intensive Care

Pain management in intensive care usually involves complex trade-offs between therapeutic goals and patient safety, since both inadequate and excessiv...

Jan 30 2026 2601.23154v1
Multi-omic deep learning identifies exercise-responsive ageing pathways in humans

Genome-wide association studies of physical activity traits have mapped numerous loci, yet the molecular mechanisms through which exercise influences ...

Noninvasive and Objective Near Real-Time Detection of Pain Changes in Fluctuating Pain

Chronic pain involves natural intensity fluctuations that patients cannot control, contributing to learned helplessness and functional impairment. Det...

Electrophysiological Correlates of Reinforcement Learning in the Human Ventral Tegmental Area

The ventral tegmental area is the primary source of dopaminergic input to the human prefrontal cortex and plays a central role in reinforcement learni...

GLEN-Bench: A Graph-Language based Benchmark for Nutritional Health

Nutritional interventions are important for managing chronic health conditions, but current computational methods provide limited support for personal...

Jan 26 2026 2601.18106v1
Population-Scale Analysis of Frequency-Dependent Calcium Dynamics in Retinal Ganglion Cells Under Electric Field Stimulation

Electric field (EF) stimulation is an emerging neuromodulatory strategy for promoting the repair and functional recovery of degenerated neural network...

TOSHFA: A Mobile VR-Based System for Pose-Guided Exercise Rehabilitation for Low Back Pain

Low back pain (LBP) is a pervasive global health challenge, affecting approximately 80% of adults and frequently progressing into chronic or recurrent...

Jan 24 2026 2601.17553v1
Camera-Agnostic Autonomous Diagnosis of Glaucomatous Optic Neuropathy using Macular Fundus Imaging and Machine Learning

Abstract Purpose: Glaucoma, a leading cause of irreversible vision loss, often remains undiagnosed due to its asymptomatic progression and the limitat...

Pain-regulation circuitry as a predictor of chronic pain phenotypes

Background: Chronic pain is a multidimensional condition in which emotional distress, negative expectations, and functional impairment signal greater ...

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