Latest AI and machine learning research in pain management for healthcare professionals.
Humans can experience auditory pain in response to sound, either from extremely loud noise or in cases of pain hyperacusis, where typically tolerable sounds become painful. However, the mechanisms underlying auditory pain remain poorly understood. Developing behavioral methods to measure sound-evoked pain in animal models is critical for elucidating these mechanisms. Here, a deep learning-based ap...
Functional genetic screens have uncovered dependencies in many cancers, but experimentally screened models for most cancers are far outnumbered by molecularly-profiled tumors, particularly for rare cancers. We used machine learning to infer gene dependencies from tumor transcriptional profiles, applying our model to the TCGA (11,373 tumors; 28 lineages), rare cancers (1,034 tumors, including 17 ki...
Joint pain is an increasing concern for our aging population, as current therapies to slow joint disease progression or reduce pain are largely ineffe...
Endogenous pain modulation is thought to encompass a crucial evolutionary purpose in guiding decision-making away from harm. This is well exemplified ...
Chronic low back pain (CLBP) has been linked to maladaptive cortical plasticity in sensorimotor regions, which may contribute to pain persistence thro...
Activity-dependent synaptic plasticity is a fundamental learning mechanism that shapes connectivity and activity of neural circuits. Existing computat...
Humans routinely anticipate upcoming language, but whether such predictions come at a cognitive cost remains debated. In this study, we demonstrate th...
Understanding how genomic sequences shape three-dimensional (3D) genome architecture is funda-mental to interpreting diverse biological processes. Alt...
The advancement of artificial intelligence (AI) has reshaped drug discovery. AI-based models typically rely on molecular representations for predictio...
Placebo analgesia is a well-established medical phenomenon with overlapping neural representations between humans and rodents, but the genetic contrib...
The vagus nerve transmits vital signals between organ systems of the body and the brain. Despite growing interest in non-invasive transcutaneous vagus...
The BCL-XL anti-apoptotic protein is a clear cell Renal Cell Carcinoma (ccRCC) dependency; however, the mechanism of this dependence and its relevance...
Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system that results in varying degrees of functional impairment. Conven...
Low back pain (LBP) is a leading cause of disability worldwide, with up to 25% of cases become chronic (cLBP). Optimal diagnostic tools for cLBP remai...
Frontotemporal lobar degeneration-TDP Type C (TDP-C) is a unique neurodegenerative disease that starts by attacking the anterior temporal lobe leading...
Numerical variations and transitional anatomy in the human vertebral column, observed in up to 36% of individuals, represent a significant yet underst...
Characterizing the cardinal neuropathologies in Alzheimer disease (AD) can be laborious, time consuming, and susceptible to intra- and inter-observer ...
Accumulating evidence suggests that migraine patients present abnormal brain responses to salient sensory and emotional stimuli. However, it is still ...
Pelvic pain (dysmenorrhea and non-menstrual) is the most common presentation of adolescent endometriosis, but symptoms vary between and within patient...
Despite the ongoing opioid epidemic, the mortality risk of opioid initiation in patients with dementia or mild cognitive impairment (MCI) remains unde...