Pathology

Latest AI and machine learning research in pathology for healthcare professionals.

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Pulmonary Cytology in Transformation.

BACKGROUND: Traditionally, pulmonary cytology has been used to diagnose and screen for a variety of respiratory diseases, including lung cancer. Owing to its rapid turnaround time compared with histological diagnosis, therapeutic decisions may occasionally need to be made based on cytological findings alone. In the era of precision medicine, however, biomarker assessment and molecular testing have...

Sep 5 2026 42700421

Artificial Intelligence-Assisted MRI and CT-Based Diagnostic Anatomical Evaluation of Experimental Rat Disease Models.

Artificial intelligence (AI) emerged as the transformative technology in biomedical imaging to improve the accuracy, efficiency and reproducibility of disease diagnosis. Integration of multimodal imaging data for the automated anatomical assessment in preclinical disease models remains insufficiently explored. This study aimed to develop and validate an AI-assisted framework integrating the magnet...

Sep 5 2026 42700808
Application of Emerging Technologies in the Antiviral Field.

Viral diseases pose a serious threat to global public health, agriculture, and biosecurity. Conventional antiviral strategies are often limited by an ...

Sep 5 2026 42700916
Advanced hemodynamic monitoring of the patient with acute heart failure and cardiogenic shock.

PURPOSE OF REVIEW: To provide a practical, physiology-driven framework for advanced hemodynamic monitoring in patients with acute heart failure (AHF) ...

Sep 4 2026 42700460
Deep learning in breast cancer histopathology: predicting and detecting axillary lymph node metastasis.

Deep learning (DL) methods are increasingly applied to digitized hematoxylin and eosin (H&E) slides in breast cancer to assist in staging and prognosi...

Sep 4 2026 42696054
Machine Learning Models for Predicting Response to Percutaneous Transhepatic Biliary Drainage in Malignant Obstructive Jaundice: A Retrospective Cohort Study.

BACKGROUND AND AIMS: Percutaneous transhepatic biliary drainage (PTBD) is a standard palliative intervention for malignant obstructive jaundice, yet 6...

Sep 4 2026 42696113
Real-Time Nanoscale Multiparametric Biophysical Phenotyping of Single Cells by Surface Plasmon Resonance Microscopy.

How cell physical state relates to function and stimulus response remains difficult to resolve because most methods measure only one biophysical prope...

Sep 4 2026 42696700
Deep learning on contrast-enhanced computed tomography for parotid tumor classification: Providing crucial diagnostic information beyond clinical and radiologic evaluation.

PURPOSE: Preoperative differentiation between benign and malignant parotid tumors (PTs) remains challenging despite clinical examination, cross-sectio...

Sep 4 2026 42696858
Comparative analysis of human papilloma virus detection methods and prognostic significance of transcriptionally active viral load in oropharyngeal squamous cell carcinoma.

BACKGROUND: Human papilloma virus (HPV)-related head and neck squamous cell carcinoma (HNSCC) incidence is rising. Despite the prognostic and therapeu...

Sep 4 2026 42696859
Breaking the Autophagy-Oxidative Stress Vicious Cycle in Alzheimer's Disease: Lactiflorin Unlocks P62 Dual Phosphorylation via ULK1 Targeting.

ETHNOPHARMACOLOGICAL RELEVANCE: The dried root of Paeonia lactiflora Pall. has a long history of medicinal use in traditional Chinese medicine. Classi...

Sep 4 2026 42697496
Quantitative analysis of artificial intelligence-based detection of subregions from murine ear skin sections with application to quantifying drug-induced epidermal hyperplasia.

The advent of artificial intelligence (AI) technologies is creating a paradigm shift in drug discovery and development. Veterinary pathology is an are...

Sep 4 2026 42693916
ToxCompl Completion of the DrugMatrix Toxicogenomics Database: An Integrated Resource for Toxicological Hypothesis Generation.

The DrugMatrix database contains systematically generated toxicogenomics data from short-term in vivo studies for over 600 chemicals. However, most po...

Sep 4 2026 42693954
Development of a YOLO-guided automated (microplastic) particle analysis workflow.

Microplastics (MPs) are an emerging pollutant of global concern, creating an urgent need for rapid and accurate monitoring workflows. Deep learning-ba...

Sep 4 2026 42694007
Risk Stratification of Incidental Pulmonary Nodules: A Fully Automated Approach to CT Imaging Analysis.

BACKGROUND: Incidental detection is the most common pathway through which pulmonary nodules are identified. With the advancement of navigational and r...

Sep 3 2026 42689326
Recent advancements in exosomal content analysis: the future of liquid biopsy.

Exosomes are widely acknowledged as an essential agent that carries biomarkers for specific diseases, representing the molecular status of their paren...

Sep 3 2026 42690454
Lightweight Transformer-based knowledge distillation framework for high-dimensional spatiotemporal radiomics in breast cancer risk prediction.

Breast cancer exhibits significant spatiotemporal heterogeneity. Traditional radiomics approaches usually rely on low-temporal-resolution imaging and ...

Sep 3 2026 42690533
Machine Learning and Molecular Modeling Reveal HDAC6 as a Key Target of Tanshinone IIA in Multiple Myeloma.

Multiple myeloma (MM) is a malignant blood cancer marked by severe bone destruction and immune microenvironment disruption. Yet relapse and drug resis...

Sep 3 2026 42691419
CLDN18 as a novel junctional biomarker enhancing multi-gene classification of pancreatic cancer.

Pancreatic adenocarcinoma (PAAD) remains one of the most lethal cancers, largely due to the lack of reliable diagnostic biomarkers. Through integrativ...

Sep 3 2026 42691511
NucGen3D: A synthetic framework for large-scale 3D nuclear segmentation with open-source training data and models.

Robust nuclear segmentation in 3D microscopy images is a critical yet unsolved challenge in quantitative cell biology. The main challenges are the sca...

Sep 3 2026 42691814
Analyzing transitions, safety and influencing factors of driving patterns as multivariate short-term behaviors in freeway diverging areas.

Freeway diverging areas require drivers to decelerate, change lanes, and observe traffic simultaneously, resulting in elevated crash risk compared to ...

Sep 3 2026 42691937
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