Pathology

Histopathological Differences Between Idiopathic and Secondary Interstitial Pneumonia: An Elastic Fiber-Oriented Deep Learning Analysis.

Fibrotic interstitial lung diseases (ILDs) are classified into histopathological patterns by the idiopathic interstitial pneumonia (IIP) classification, and not only IIP but also secondary interstitial pneumonia (SIP) are evaluated based on the classification system, and the final integrated diagnosis is established through multidisciplinary discussion. However, distinguishing IIP from SIP is ofte...

Artificial intelligence-driven transformation in the management of atypia of undetermined significance (AUS) thyroid nodules.

Atypia of undetermined significance (AUS) thyroid nodules account for 10-30% of thyroid fine-needle aspiration (FNA) cytology results, with a malignant risk ranging from 13-30%. Currently, there is no unified diagnostic and treatment protocol for AUS. Clinical diagnosis faces challenges including imprecise malignant risk assessment, low diagnostic consistency among cytopathologists, and significan...

ADRB2 Modulates Asbestos-Induced Pleural Mesothelioma Progression by Influencing IL-17/NF-κB-Related Inflammatory Signalling: An Integrated Network Toxicology, Multi-Omics and Experimental Study.

Pleural mesothelioma (PM) is a highly aggressive asbestos-related malignancy with poor prognosis and limited early diagnostic options. In this study, ...

Can Multiomics Modeling Enable Accurate Prediction of Microsatellite Instability in Colorectal Cancer?

RATIONALE AND OBJECTIVES: To investigate a multimodal deep learning model integrating computed tomography (CT) radiomics and histopathologic pathomics...

Trajectory-aware risk stratification of oral lichen planus using a multimodal large language model: a longitudinal diagnostic accuracy study.

To evaluate the performance of a multimodal large language model (LLM) for longitudinal trajectory classification and risk stratification of oral lich...

Radiomics-Based AI for Predicting Neoadjuvant Immunochemotherapy Pathological Response in Non-Small Cell Lung Cancer: Systematic Review and Meta-Analysis.

BACKGROUND: Non-small cell lung cancer (NSCLC) remains the leading cause of cancer-related mortality worldwide. Accurate early prediction of response ...

Machine learning and multi-omics technologies for precision cardiovascular medicine: advancing diagnosis, risk prediction, and therapeutic guidance.

Cardiovascular disease remains a major global health burden. Owing to its complex pathogenesis and marked clinical heterogeneity, conventional one-siz...

Bridging fibrosis and function: an integrated mechanistic and therapeutic framework for Peyronie's disease and related erectile dysfunction.

INTRODUCTION: Peyronie's disease (PD) and erectile dysfunction (ED) are prevalent and frequently coexisting male sexual disorders that share endotheli...

aDISCO: A clearing method to enable 3D microscopy of large archival paraffin-embedded human tissue blocks.

Human surgery and autopsy specimens are routinely stored as formalin-fixed paraffin-embedded (FFPE) tissue blocks for decades, creating vast archives ...

A Deep Learning Pipeline for Cell Segmentation and Viability Quantification in 3D Constructs From Fluorescence Microscopy Images.

With the increasing adoption of 3D cell cultures and bioprinting in biomedical research, there is a growing demand for reliable and accurate monitorin...

Additional sectioning and AI-assisted diagnosis reveal underdiagnosis of serous (pre)malignancies in fallopian tube specimen from BRCA1/2 carriers.

AIM: Germline BRCA1/2 pathogenic variant carriers are at increased risk for high-grade serous carcinoma (HGSC) and are therefore advised to have a ris...

CCT2 Promotes Immune Escape in Colorectal Cancer by Regulating the JAK1-STAT3-PD-L1 Axis.

BACKGROUND: Colorectal cancer (CRC) is a major global health burden. While immune checkpoint inhibitors have greatly advanced cancer therapy, their th...

A radiomic approach to non-invasively decode tumor immune microenvironmental features in surgically resected non-small cell lung cancer.

INTRODUCTION: This study aimed to develop radiomics-based multivariate classifiers able to non-invasively decipher the tumor immune microenvironment (...

Erjingwan Alleviates Parkinson's Disease via Activation of PPARA-Mediated Autophagy.

Parkinson's disease (PD) is characterized by progressive dopaminergic neuronal degeneration and neuroinflammation. Traditional Chinese medicine (TCM) ...

Postoperative Nocardia cyriacigeorgica infection after glioblastoma resection: correlating metagenomic next-generation sequencing with conventional microbiology.

Postoperative nocardial infection after cranial surgery is rare and difficult to diagnose because Nocardia spp. grow slowly in conventional culture. M...

Li+ Transport in Ca-Substituted β-Li3PS4: Role of PS43- Vibrations and Rotations from Machine-Learning Molecular Dynamics.

Sulfide-based solid electrolytes are key materials for all-solid-state batteries owing to their high Li+ conductivity. In particular, β-Li3PS4 with al...

MINPP1, HES4 and SLCO5A1 as core signature genes mediating the effects of type 2 diabetes on coronary artery bypass grafting.

PURPOSE: This study aimed to identify the signature genes that mediate the effects of type 2 diabetes (T2D) on coronary artery bypass grafting (CABG),...

Clinically interpretable prediction models of stroke functional outcomes: A national cohort study of adults in inpatient rehabilitation facilities in the US.

OBJECTIVE: To predict self-care and mobility function at discharge from inpatient rehabilitation for adults with stroke using only variables from the ...

Global Research Trends and Future Perspectives in Salivary Gland Oncology: A Scientometric Evaluation.

INTRODUCTION: Salivary gland tumors (SGTs) comprise a heterogeneous group of neoplasms with diverse histopathological and molecular features. AIM: Thi...

INTERPRETABLE DEEP LEARNING APPLIED TO FLUORESCENCE CONFOCAL MICROSCOPY FOR INTRAOPERATIVE TISSUE ASSESSMENT IN PEDIATRIC SURGICAL ONCOLOGY.

BACKGROUND: In pediatric surgical oncology, intraoperative tissue assessment is limited by small specimen size and the absence of real time histopatho...