Pathology

Spatially resolved tissue architecture and computational pathology in pancreatic cancer.

Pancreatic ductal adenocarcinoma (PDAC) is a complex disease characterized by high levels of cellular heterogeneity and pronounced microenvironmental remodelling. Dynamic changes during its initiation and progression contribute to resistance to conventional therapies. Building upon key molecular catalogues established by bulk and single-cell profiling studies that have advanced our understanding o...

Artificial intelligence empowers full-stack histopathological diagnosis and prognosis of renal cell tumor: a multi-center study with external validation.

BACKGROUND: The rapid advancement of digital pathology has opened unprecedented opportunities for intelligent diagnosis in renal cell tumor. However, there remains a significant gap in the availability of reliable deep learning models capable of comprehensive kidney cancer detection, classification, grading, and survival prediction. METHOD: This study retrospectively analyzed 11,135 whole-slide im...

Integrative Genomic Analysis Reveals Molecular and Clinical Disparities between Bladder and Upper Tract Urothelial Carcinoma in K-MASTER Program.

PURPOSE: The clinical outcome of urothelial carcinoma presents significant variability, reflecting its molecular composition, epidemiologic attributes...

Deep learning-based prostate cancer diagnosis on MRI with hip prostheses: artifact and sequence effects.

OBJECTIVE: To evaluate the impact of hip prosthesis-induced artifacts on the diagnostic performance of deep learning (DL)-based prostate cancer diagno...

EMBC Special Issue: SAM-HovNet: SAM-Enhanced Multi-Class Nucleus Segmentation and Classification in Hepatocellular Carcinoma Slides.

Hepatocellular carcinoma (HCC) is the most common primary liver cancer and a leading cause of cancer-related mortality. Manual nuclear analysis in HCC...

Nurse-Led Large Language Model Chatbot for Predicting and Preventing Complications After Coronary Artery Bypass Grafting: Protocol for a Randomized Controlled Trial.

BACKGROUND: Thirty-day unplanned readmission following coronary artery bypass grafting (CABG) affects 10%-20% of patients and is a key quality indicat...

Beyond prediction: Why experimental structural biology remains essential in plants.

Structural biology is undergoing a transformative era driven by advances in artificial intelligence (AI)-based protein structure prediction and cryo-e...

Volumetric denoising enables high-throughput volume electron microscopy and efficient downstream analysis.

Volume electron microscopy (VEM) enables nanometer-resolution three-dimensional (3D) visualization of biological specimens via serial sectioning and i...

Beyond Diagnosis: Magnetic Resonance Imaging-Based Imaging Biomarkers for Tumor Biology, Prognosis, and Clinical Decision-Making in Hepatocellular Carcinoma.

Hepatocellular carcinoma (HCC) is a biologically heterogeneous malignancy staged according to tumor burden and clinical status. Molecular and histopat...

Early Follicular Lymphoma Grading via PET-CT Fusion and Bayesian Deep Learning.

Accurate grading of follicular lymphoma (FL) is crucial for personalized treatment, but biopsy-based histopathology is invasive and limited by observe...

Artificial intelligence in breast cancer imaging: a systematic review of diagnostic performance, predictive modeling, and clinical translation.

Artificial intelligence (AI) has rapidly advanced in breast cancer imaging, demonstrating high diagnostic and predictive performance across imaging mo...

Artificial intelligence-based diagnostic model for identifying PTPRZ1-MET fusion in a clinically defined secondary glioblastoma cohort.

Glioblastoma (GBM) is an aggressive and highly lethal brain tumor. Secondary glioblastoma (sGBM), which arises through malignant progression from lowe...

Bo-Net: Deep learning-based model for automatic bone stromal cell segmentation of fluorescence microscopy images.

BACKGROUND AND OBJECTIVES: Bone is a multicellular organ that is the site of complex pathophysiological events (such as cancer). 3D confocal and multi...

AI-assisted post-mortem classification of vehicle trauma in free-roaming cats using transformer-based large language models.

Veterinary forensic science is a specialized discipline that investigates non-natural animal deaths and injuries. Determining the cause of death in fr...

Present status of prostate cancer diagnosis, limitations, challenges, and future endeavors.

Methods: In addition to traditional testing methods, the use of PSMA-directed imaging to guide biopsy procedures using Multiparametric Magnetic Resona...

Sensitive detection of unopposed estrogen using estrogen receptor functionalized nanoprobes for cancer diagnosis.

Unopposed estrogen refers to prolonged estrogenic stimulation in the absence of adequate progesterone-mediated counter-regulation. Unopposed estrogen ...

Peripheral blood profiles reflecting progenitor lineage balance are associated with molecular response in chronic myeloid leukemia.

Early achievement of deep remission improves patients' outcome in chronic myeloid leukemia (CML) treatment, highlighting the need for predictive indic...

Dentin-Normalized CBCT Radiomics within a Periapical Lesion Differential Diagnosis System for Differentiating Granulomas and Radicular Cysts.

INTRODUCTION: Periapical granulomas and radicular cysts cannot be reliably differentiated by clinical examination or conventional radiography. Histopa...

CHRNA5 orchestrates tumorigenesis and immune invasion through the CaMKII/AKT/NF-κB-CCL20 axis in pancreatic ductal adenocarcinoma.

AIMS: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy characterized by poor prognosis, extensive perineural invasion (PNI), ...

A Multimodal Ultrasound Radiomics Model Integrating Contrast-Enhanced Phases: Retrospective Temporal Test Cohort Evaluation and Comparison with Sonographers for Cervical Lymph Node Characterization.

RATIONALE AND OBJECTIVES: To develop a multimodal ultrasound radiomics model based on conventional ultrasound and three-phase contrast-enhanced ultras...