Pathology

Latest AI and machine learning research in pathology for healthcare professionals.

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Multifaceted role of histopathology in liver transplantation for hepatocellular carcinoma: A narrative review towards precision prognosis.

Hepatocellular carcinoma is a leading cause of cancer mortality globally. Liver transplantation is considered the best curative treatment for selected patients, as it removes the tumor and restores hepatic function. However, organ scarcity requires precise prognostic stratification. Histopathology is the essential bridge between morphology and biology, offering unique insights into tumor aggressiv...

Jun 18 2026 42281878

An in situ non-contact 3D microscopic measurement system for temporal bone anatomy based on stereo imaging.

Accurate quantitative assessment of temporal bone microanatomy is essential for otologic research and surgical planning. However, existing measurement approaches, including manual tools, ex vivo microscopy, and high-resolution computed tomography, are limited by contact requirements, indirect measurement, insufficient spatial resolution, or the inability to provide efficient quantitative feedback ...

Jun 18 2026 42310033
Deep integration of clinical metadata with [18F]FDG PET/CT imaging for histological subtyping in non-small cell lung cancer: a multi-center study.

PURPOSE: To develop and validate a multimodal deep learning framework that integrates clinical metadata with [18F]FDG PET/CT imaging to resolve overla...

Jun 18 2026 42310216
Building a Clinically Relevant and Technically Robust Synthetic Histopathology Dataset for Breast and Gastric Cancer.

Data scarcity, inter-institutional stain variability, and privacy constraints are major challenges impeding the development of generalizable artificia...

Jun 18 2026 42310241
Identifying breast cancer subtypes and exploring spatial expression patterns of the key subtype-specific gene based on pathological images, single-cell sequencing, and spatial transcriptomic data.

BACKGROUND: Breast cancer (BRCA) is a heterogeneous disease. Accurate prognosis and molecular subtypes are critical for personalized treatment in BRCA...

Jun 18 2026 42310259
Integrating artificial intelligence into cancers of unknown primary diagnosis and treatment.

Cancers of unknown primary (CUP) refer to a highly heterogeneous group of metastatic tumors whose primary site remains undetectable despite comprehens...

Jun 17 2026 42375542
Automated diagnosis of Helicobacter pylori infection from routine endoscopic images using deep learning: a development and validation study.

BACKGROUND: Real-time endoscopic diagnosis of Helicobacter pylori infection remains challenging and often requires biopsy-based testing, delaying trea...

Jun 17 2026 42310547
Identification of potential biomarkers for ulcerative colitis based on multidimensional data analysis and investigation of the mechanisms of therapeutic effects.

OBJECTIVE: Based on multidimensional data analysis, potential biomarkers for ulcerative colitis were screened, and the effects of curcumin chitosan mi...

Jun 17 2026 42310554
A transformer-based multimodal deep learning model for preoperative prediction of Ki-67 expression level in glioma.

PURPOSE: The aim of this study is to develop a deep learning model using preoperative multimodal MR data to predict the Ki-67 expression level of glio...

Jun 17 2026 42310560
Intelligent three-dimensional imaging in pathology: Applications and developments.

Conventional two-dimensional (2D) pathology relies on a limited number of tissue sections and therefore provides information from isolated planes, whi...

Jun 17 2026 42311028
External Validation of a Deep Learning-Based Artificial Intelligence System for Ultrasound Diagnosis of Thyroid Nodules: A Two-Center Retrospective Study.

OBJECTIVES: To investigate the performance of an artificial intelligence (AI) diagnostic system for thyroid nodule sonography based on deep learning c...

Jun 17 2026 42304967
Weight-Controllable Biobarcode Probes for Multi-input Breast Cancer Diagnosis.

DNA-based molecular classifiers have emerged as a promising strategy for precise cancer diagnosis, offering a superior alternative to invasive biopsy ...

Jun 17 2026 42306980
Counterfactual Diffusion Models Provide Interpretable Explanations of Artificial Intelligence Models in Pathology.

Deep learning can extract predictive and prognostic biomarkers from histopathology whole-slide images. However, explainable artificial intelligence ap...

Jun 17 2026 42308255
Visceral adipose tissue inflammation in endometrial cancer.

BACKGROUND: Obesity is the largest risk factor for endometrial cancer. Body Mass Index (BMI) does not fully capture obesity's metabolic and inflammato...

Jun 17 2026 42308582
Integrated toxicological analysis links air pollution-associated acute respiratory distress syndrome signatures to benzo[a]pyrene-induced acute lung injury.

Acute respiratory distress syndrome (ARDS) is associated with high mortality, and increasing evidence suggests that air pollution may contribute to it...

Jun 17 2026 42309011
MRI-Based estimation of physiologically consistent head conductivity and its impact on depth-dependent electric field distributions in transcranial magnetic stimulation.

Accurate estimation of spatially heterogeneous conductivity distributions is essential for reliable electric field modeling in non-invasive brain stim...

Jun 17 2026 42309136
Machine learning-assisted prediction of PANoptosis-related molecular targets and precise screening of neuroprotective drugs for spinal cord injury.

Spinal cord injury (SCI) is a highly disabling central nervous system disease with complex pathology, and targeted neuroprotective drugs remain clinic...

Jun 17 2026 42309342
Single-cell transcriptomic analysis reveals the T lymphocyte microenvironment and identifies HOPX as a hub gene in membranous nephropathy.

BACKGROUND: Membranous nephropathy (MN) is an autoimmune disease characterized by immune complex deposition and progressive renal function impairment....

Jun 17 2026 42309401
Clinical Validation of the MC-80 Digital Morphology Analyzer in Leukocyte Classification: A Large-Scale Comparison With Manual Microscopy.

INTRODUCTION: Although AI-powered digital morphology analyzers are widely used for leukocyte classification, their reliability in detecting clinically...

Jun 17 2026 42309506
Ultrasonographic Phenotypes and Segmentation Model Comparison for Primary Breast Lesions and Axillary Lymph Nodes in Triple-negative Breast Cancer.

RATIONALE AND OBJECTIVES: To describe clinicopathologic and ultrasonographic heterogeneity across immunohistochemistry-based FUSCC surrogate subtypes ...

Jun 17 2026 42309955
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