Pathology

Latest AI and machine learning research in pathology for healthcare professionals.

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Assessing Rectal Cancer Treatment Response Using Coregistered Endorectal Photoacoustic and US Imaging Paired with Deep Learning.

Background Conventional radiologic modalities perform poorly in the radiated rectum and are often unable to differentiate residual cancer from treatment scarring. Purpose To report the development and initial patient study of an imaging system comprising an endorectal coregistered photoacoustic (PA) microscopy (PAM) and US system paired with a convolution neural network (CNN) to assess the rectal ...

Mar 23 2021 33754826

Machine learning-based reclassification of germline variants of unknown significance: The RENOVO algorithm.

The increasing scope of genetic testing allowed by next-generation sequencing (NGS) dramatically increased the number of genetic variants to be interpreted as pathogenic or benign for adequate patient management. Still, the interpretation process often fails to deliver a clear classification, resulting in either variants of unknown significance (VUSs) or variants with conflicting interpretation of...

Mar 23 2021 33761318
Accurate diagnosis of colorectal cancer based on histopathology images using artificial intelligence.

BACKGROUND: Accurate and robust pathological image analysis for colorectal cancer (CRC) diagnosis is time-consuming and knowledge-intensive, but is es...

Mar 23 2021 33752648
Raman spectroscopy and artificial intelligence to predict the Bayesian probability of breast cancer.

This study addresses the core issue facing a surgical team during breast cancer surgery: quantitative prediction of tumor likelihood including estimat...

Mar 22 2021 33753760
Coupling Machine Learning and Lipidomics as a Tool to Investigate Metabolic Dysfunction-Associated Fatty Liver Disease. A General Overview.

Hepatic biopsy is the gold standard for staging nonalcoholic fatty liver disease (NAFLD). Unfortunately, accessing the liver is invasive, requires a m...

Mar 22 2021 33810079
Robotic-assisted radical prostatectomy following colo-rectal surgery: a user's guide.

To assess the feasibility and operative outcomes of RARP following colo-rectal surgery. A prospective database of patients undergoing RARP is maintain...

Mar 20 2021 33743146
Host-dependent molecular factors mediating SARS-CoV-2 infection to gain clinical insights for developing effective targeted therapy.

Coronavirus disease 2019 (COVID-19), a recent viral pandemic that first began in December 2019, in Hunan wildlife market, Wuhan, China. The infection ...

Mar 20 2021 33743061
A multi-phase deep CNN based mitosis detection framework for breast cancer histopathological images.

The mitotic activity index is a key prognostic measure in tumour grading. Microscopy based detection of mitotic nuclei is a significant overhead and n...

Mar 18 2021 33737632
Development and validation of a sensitive LC-MS/MS method for pioglitazone: application towards pharmacokinetic and tissue distribution study in rats.

In the present study, a sensitive LC-MS/MS method was developed and validated to measure pioglitazone (PGZ) concentrations in rat plasma and tissues. ...

Mar 18 2021 35423625
Deep learning based segmentation of brain tissue from diffusion MRI.

Segmentation of brain tissue types from diffusion MRI (dMRI) is an important task, required for quantification of brain microstructure and for improvi...

Mar 16 2021 33737246
Deep learning detects genetic alterations in cancer histology generated by adversarial networks.

Deep learning can detect microsatellite instability (MSI) from routine histology images in colorectal cancer (CRC). However, ethical and legal barrier...

Mar 16 2021 33565124
Deep Learning Automated Segmentation for Muscle and Adipose Tissue from Abdominal Computed Tomography in Polytrauma Patients.

Manual segmentation of muscle and adipose compartments from computed tomography (CT) axial images is a potential bottleneck in early rapid detection a...

Mar 16 2021 33809710
A Deep Learning Approach to Diagnostic Classification of Prostate Cancer Using Pathology-Radiology Fusion.

BACKGROUND: A definitive diagnosis of prostate cancer requires a biopsy to obtain tissue for pathologic analysis, but this is an invasive procedure an...

Mar 14 2021 33719168
Handcrafted MRI radiomics and machine learning: Classification of indeterminate solid adrenal lesions.

PURPOSE: To assess a radiomic machine learning (ML) model in classifying solid adrenal lesions (ALs) without fat signal drop on chemical shift (CS) as...

Mar 13 2021 33727148
Predicting gastric cancer outcome from resected lymph node histopathology images using deep learning.

N-staging is a determining factor for prognostic assessment and decision-making for stage-based cancer therapeutic strategies. Visual inspection of wh...

Mar 12 2021 33712598
The evolving role of EUS-guided tissue acquisition.

The introduction of endoscopic ultrasound-guided fine-needle aspiration into clinical practice was a pivotal moment for diagnostic gastrointestinal en...

Mar 11 2021 33611846
Diagnosis prediction of tumours of unknown origin using ImmunoGenius, a machine learning-based expert system for immunohistochemistry profile interpretation.

BACKGROUND: Immunohistochemistry (IHC) remains the gold standard for the diagnosis of pathological diseases. This technique has been supporting pathol...

Mar 11 2021 33706755
Fine-Tuning and training of densenet for histopathology image representation using TCGA diagnostic slides.

Feature vectors provided by pre-trained deep artificial neural networks have become a dominant source for image representation in recent literature. T...

Mar 10 2021 33773296
A new rapid diagnostic system with ambient mass spectrometry and machine learning for colorectal liver metastasis.

BACKGROUND: Probe electrospray ionization-mass spectrometry (PESI-MS) can rapidly visualize mass spectra of small, surgically obtained tissue samples,...

Mar 10 2021 33691644
Deep learning classification of lung cancer histology using CT images.

Tumor histology is an important predictor of therapeutic response and outcomes in lung cancer. Tissue sampling for pathologist review is the most reli...

Mar 9 2021 33727623
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