Pathology

Latest AI and machine learning research in pathology for healthcare professionals.

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Sidelobe suppression of Barker codes via MRH method.

The Barker code is widely used in ultrasonic testing to enhance transmitted energy and achieve high-resolution pulse compression through a matched filter. However, the inherent sidelobe of the Barker code can obscure defect echoes under tough testing environments. To solve this problem, a combined processing method integrating a matched filter, Richardson-Lucy (RL) deconvolution, and a high-pass f...

Apr 23 2026 42033957

Multidimensional transcriptomic analysis and in vitro experiments dissect the landscape of 2',2',4',4'-Tetrabromodiphenyl ether in bladder cancer progression.

2',2',4',4'-Tetrabromodiphenyl ether (BDE-47), the most widespread congener of polybrominated diphenyl ethers, has attracted considerable attention due to its environmental persistence and extensive use. Although epidemiological data associate BDE-47 exposure with increased cancer risk, its role in bladder cancer (BC) remains insufficiently characterized. We found that BDE-47 at a physiologically ...

Apr 23 2026 42034337
MechanoAge, a machine learning platform to identify individuals susceptible to breast cancer based on mechanical properties of single cells.

BACKGROUND: Emerging evidence links cellular ageing and biophysical alterations with cancer susceptibility. Existing breast cancer risk models inadequ...

Apr 23 2026 42031621
Percutaneous Lung Biopsies Aided by Artificial Intelligence: A Comparison Between Computer and Physician-Chosen Biopsy Paths.

OBJECTIVE: To compare Trajectory Recommendation Algorithm for CT-guided Biopsy (TRAX)-generated lung biopsy puncture pathways versus physician-chosen ...

Apr 23 2026 42023650
Advancing collagen-related pathology assessment through second-harmonic generation imaging.

Collagen remodelling and dysregulation are the hallmarks of diverse pathological conditions. In this context, second-harmonic generation (SHG) imaging...

Apr 23 2026 42024484
AI in Atomic Force Microscopy: Advancing Biological Nanoscale Imaging and Autonomous Discovery.

Atomic force microscopy (AFM) enables label-free nanoscale imaging and nanomechanical profiling but remains constrained by low throughput, operator de...

Apr 23 2026 42024823
SAM2HIPT: A hybrid deep learning framework integrating SAM2 and HIPT with joint loss optimization for immunohistochemical cell nucleus segmentation.

Nucleus segmentation in immunohistochemistry (IHC) images plays a critical role in cancer diagnosis and treatment assessment. However, existing method...

Apr 23 2026 42025178
Parametrically upscaled model-based predictive platform for fatigue with location-specific microstructural linkages.

Fatigue in metallic materials is a cost-intensive engineering challenge due to unpredictable occurrences when undergoing cyclic loading. Particularly ...

Apr 23 2026 42020387
Early detection and subtyping of gastric cancer: A cell-free DNA fragmentome-based liquid biopsy method.

Cell-free DNA (cfDNA) in plasma provides attractive opportunities for early cancer diagnosis. This study aimed to establish gastric cancer (GC) artifi...

Apr 22 2026 42109851
Modelling the epidemic dynamics of HPV among women in China and optimization of ongoing cervical cancer elimination strategies.

BACKGROUND: The infection of high-risk human papillomavirus (hr-HPV) and related cervical cancer have greatly threatened women's health. However, the ...

Apr 22 2026 42021319
Protocol for an interpretable self-attention artificial neural network framework to predict cancer risk in oral potentially malignant disorders.

Oral potentially malignant disorders (OPMDs) can directly progress to cancer, necessitating accurate risk prediction to guide clinical intervention. H...

Apr 22 2026 42024509
Bolstering the Performance of Breast Radiologists with AI-CAD in Mammography: A Multireader Study.

RATIONALE AND OBJECTIVES: Breast cancer is the most common malignancy among females globally and across most Asian countries. In 2022, Asia's age-stan...

Apr 22 2026 42025520
Urinary extracellular vesicle miRNA signature reflects pancreatic islet stress in type 2 diabetes.

INTRODUCTION: Type 2 diabetes (T2D) is a progressive metabolic disorder characterized by insulin resistance and progressive β-cell dysfunction. Early ...

Apr 22 2026 42017432
FOSL2 regulates endothelial cell state and chromatin accessibility in systemic sclerosis pulmonary vascular remodeling.

Systemic sclerosis (SSc) is characterized by fibrosis and vasculopathy affecting the skin and internal organs, leading to multiorgan dysfunction. Inju...

Apr 22 2026 42018656
Identification and molecular typing of disulfidptosis-related biomarkers in anaplastic thyroid carcinoma.

Increasing evidence suggests that disulfidptosis plays a crucial role in tumorigenesis and progression. This study aimed to identify biomarkers closel...

Apr 22 2026 42020364
A new era of precision diagnosis and treatment for lung cancer: artificial intelligence-driven multimodal data integration and clinical applications.

Certain characteristics, such as high heterogeneity, a complex tumor microenvironment, metastatic potential, and drug resistance, render Lung cancer (...

Apr 22 2026 42020390
The University of Texas Southwestern Glioma Dataset - MRI, Molecular Markers and Segmentations.

Gliomas are the most common type of primary brain tumors. Their management options and outcomes depend significantly on the underlying molecular-marke...

Apr 22 2026 42020453
DeepFAN, a transformer-based model for human-artificial intelligence collaborative assessment of incidental pulmonary nodules in CT scans: a multireader, multicase trial.

The widespread adoption of computed tomography has increased the detection of lung nodules. However, deep learning methods for classification of benig...

Apr 22 2026 42020549
ThyroFusion: A Multi-modal Deep Learning Framework Integrating Vision and Language for Thyroid Nodule Malignancy Risk Assessment.

Accurate differentiation between benign and malignant thyroid nodules remains challenging in clinical practice. Current deep learning approaches predo...

Apr 22 2026 42020852
Multiclass lung cancer detection using a hybrid capsule inspired deep neural network.

Convolutional Neural Networks are widely used in lung cancer detection for more than a decade. However, it suffers from preserving spatial relationshi...

Apr 22 2026 42014820
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