Latest AI and machine learning research in pathology for healthcare professionals.
BACKGROUND: Colorectal cancer (CRC) is a prevalent malignant tumor of the digestive tract with high morbidity and mortality rates. Although doublecortin like kinase 3 (DCLK3) is upregulated in CRC and promotes disease progression, its specific mechanisms remain unclear. METHODS: Core factors of CRC were identified through bioinformatics analysis, weighted gene co-expression network analysis (WGCNA...
BACKGROUND: Diabetic retinopathy (DR), a serious microvascular complication of diabetes, has a complex pathogenic mechanism that is intricately linked to programmed cell death (PCD) and also to N6-methyladenosine (m6A) modification. The objective of this research was to pinpoint crucial genes related to m6A-related PCD in DR using transcriptomic data, offering novel targets and a theoretical basis...
Understanding the tumor immune microenvironment, especially tumor-infiltrating lymphocytes (TILs), remains crucial in ovarian cancer. However, the dis...
INTRODUCTION: Ovarian cancer (OC) is a highly heterogeneous and lethal gynecological malignancy. Precision oncology has shifted the management paradig...
Breast cancer (BC) ranks among the most common malignant tumors affecting women globally. The essence of precision medicine (PM) lies in "delivering t...
Neurological diseases (NDs) continue to be a leading cause of disability and mortality worldwide, largely due to delayed diagnosis and limited access ...
OBJECTIVE: To investigate the clinical characteristics associated with recurrence in malignant ovarian germ cell tumors (MOGCT) patients who received ...
Background Suboptimal human - artificial intelligence (AI) interaction is a potential roadblock for implementation of AI in clinical practice. We aime...
Low-dose computed tomography (LDCT) reduces radiation dose but, introduces heterogeneous noise due to different photon attenuation based on anato...
Multiple myeloma (MM) displays significant genetic heterogeneity, making it challenging to distinguish malignant from non-malignant plasma cells in si...
Spread through air spaces (STAS) is a recently recognized pattern of invasion in lung cancer that is strongly linked to postoperative recurrence and p...
Keratinocyte cancers (KCs) are the most prevalent cancers in white-skinned individuals, yet remain underrepresented in cancer registries because repor...
Background: Gliomas are primary malignant brain tumors. Among them, grade IV astrocytomas represent the most aggressive form with limited treatment op...
Accurate estimation of bond strength between steel reinforcement and geopolymer concrete is essential for the reliable design of sustainable reinforce...
BACKGROUND: Tissue microenvironment heterogeneity, including cellular composition, functional states, and intercellular interactions, shapes complex b...
MOTIVATION: Spatial transcriptomics (ST) can quantitatively characterize the spatial molecular profile in tissues and yet is costly to be applied at a...
Functionalized hydrogels are ideal flexible interfaces for multimodal health monitoring and integrated diagnosis-therapy systems, owing to their tissu...
Patients with multiple myeloma are frequently exposed to prolonged, multi-line and multi-drug treatment, factors that may substantially influence over...
Cancer-associated fibroblasts (CAFs) play a crucial role in the tumor microenvironment (TME) by influencing tumor progression, metastasis, and therapy...
Spatial technologies have revolutionized the study of human development by enabling molecular profiling within intact tissue architecture. Advances in...