Pathology

Exploration and validation of potential diagnostic biomarkers of PANoptosis in periodontitis using bioinformatics approaches.

BACKGROUND: Periodontitis represents a chronic inflammatory disease resulting from the interaction between plaque-associated microorganisms and the host immune response. PANoptosis, a newly recognized programmed cell death, is linked to multiple inflammatory disorders. However, its role in periodontitis pathogenesis and diagnostic potential remains unclear. This study aimed to identify key PANopto...

Huoxue Jiedu formula attenuates myocardial ischemia-reperfusion injury by modulating LAPTM4B/mTORC1/TFEB pathway-mediated autophagic flux.

BACKGROUND: Myocardial ischemia-reperfusion injury (MIRI) severely limits the benefits of revascularization in acute myocardial infarction, with impaired autophagic flux being a central pathological mechanism. The Huoxue Jiedu Formula (HXJDF), a traditional Chinese medicine prescription, has demonstrated cardioprotective potential, yet its underlying mechanisms remain unclear. PURPOSE: This study ...

AI-Based Digital Pathology-Enabled Spatial-Omics Data Analyses of the Human Kidney.

Identification of tissue-region-specific changes in glycosylation is crucial for understanding the pathogenesis of kidney diseases, yet it remains a g...

Machine learning for predicting young's modulus of soft tissues from atomic force microscopy data.

Atomic force microscopy (AFM) is an advanced tool applied to investigate the mechanical properties of a wide variety of material classes, including so...

Single-cell and spatial analyses identify a glycolysis-high state driven by STOML2 in epithelial ovarian cancer.

OBJECTIVE: Metabolic heterogeneity contributes to therapeutic resistance and poor prognosis in epithelial ovarian cancer (EOC), yet the regulatory dri...

Data modeling the interplay between single-cell shape, single-cell protein expression, and tissue state.

While cell shape fundamentally governs tissue function, the underlying links between single-cell shape and protein expression have been difficult to r...

Thiazolyl Blue as a High-Efficiency Leveler for Conformal Copper Electrodeposition in High-Aspect-Ratio PCB Through-Holes.

Driven by the rapid development of 5G/6G communications, high-performance computing, and artificial intelligence, the metallization of high-aspect-rat...

Advancing equity in endometrial cancer: A narrative synthesis using a cluster-informed framework for resource-stratified implementation.

Endometrial cancer incidence and mortality are rising globally, disproportionately affecting health systems facing diagnostic, therapeutic, and surviv...

T2-FLAIR digital subtraction radiomics versus neuroradiologist visual assessment for differentiating IDH-mutant astrocytomas from other non-enhancing low-grade gliomas: An externally validated machine learning study.

PURPOSE: Non-invasive differentiation of isocitrate dehydrogenase (IDH)-mutant, 1p/19q non-codeleted astrocytomas from other non-enhancing low-grade g...

Integrating spatial and single-cell transcriptomics via machine learning to characterize efferocytosis in hepatocellular carcinoma prognosis and immunotherapy.

BACKGROUND: The intratumoral heterogeneity and immunosuppressive microenvironment of hepatocellular carcinoma (HCC) significantly limit therapeutic ef...

Artificial intelligence with deep learning driven entropy-curvature attention mechanism for detection and segmentation of skin lesions using biomedical images.

In medical image analysis, skin lesion diagnosis remains a complicated task. Skin lesions are a prevalent form of skin disease that exists globally. A...

Multicentric data challenge for artificial intelligence-based classification of leukocytes: results from the CytologIA consortium.

Accurate morphological classification of blood leukocytes remains a cornerstone of hematological diagnostics but still relies on manual expertise, lea...

NucVerse3D: generalizable 3D nuclear instance segmentation across heterogeneous microscopy modalities.

Accurate three-dimensional (3D) nuclear instance segmentation is a prerequisite for quantitative phenotyping in volumetric microscopy, yet remains cha...

Identification and diagnosis of flow instability in parallel channel systems using machine learning.

Density wave oscillations in parallel thermal-fluid systems threaten operational safety due to uneven flow and instability. Predicting these oscillati...

HESpotEx: a dual-stream deep learning framework for spot-level gene expression prediction from histological images.

Whole-slide histopathological images (WSIs) constitute a fundamental approach in disease diagnosis and prognosis. Recently emerging spatial transcript...

Scientific highlights and perspectives from the International Inflammatory Breast Cancer Symposium 2025.

Inflammatory breast cancer (IBC) is a rare yet highly aggressive subtype of breast cancer, characterized by distinct clinical features, rapid progress...

Preoperative prediction of hepatocellular carcinoma histological grade using MRI-based artificial intelligence models: A systematic review and meta-analysis.

OBJECTIVE: To evaluate the diagnostic performance of magnetic resonance imaging (MRI)-based artificial intelligence (AI) models in preoperatively pred...

Mapping the Conformational Landscape of DNA Minicircles Through Atomic Force Microscopy and Shape Space Analysis.

The structural dynamics of DNA underpin essential biological processes, yet conventional structural biology methods often obscure conformational heter...

The role of MRCP in characterizing ductal communication and high-risk features in pancreatic cystic lesions.

Pancreatic cystic lesions are increasingly detected due to the widespread use of high-resolution cross-sectional imaging, particularly MRI and CT. The...

Artificial intelligence in small tissue biopsies: diagnostic applications, histochemical integration, and methodological challenges in surgical pathology.

Small tissue biopsies, including renal core biopsies, bone marrow trephines, gastrointestinal endoscopic samples, prostate needle cores, liver biopsie...