Pathology

Latest AI and machine learning research in pathology for healthcare professionals.

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Ultrasound Radiomics for Hashimoto's Thyroiditis: State of the Art and Future Perspectives.

Ultrasound radiomics is gradually emerging as a powerful tool for improving the diagnosis and management of Hashimoto's thyroiditis (HT), effectively overcoming the limitations of conventional ultrasound, such as high interobserver variability and difficulties in evaluating nodule characteristics. This narrative review aims to systematically summarize the fundamental principles, algorithms, and cl...

Apr 10 2026 41963245

Deepath-SCC: a deep learning model for accurate tissue origin identification in squamous cell carcinoma.

Squamous cell carcinoma (SCC) is a common malignancy that arises in diverse organs and often exhibits overlapping histological and immunophenotypic features, making accurate determination of the tissue of origin challenging with conventional pathology. To address this, we developed Deepath-SCC, a deep learning model for pan-SCC tissue origin identification directly from hematoxylin and eosin-stain...

Apr 10 2026 41963625
Clinical Translatable and Transparency of Neural Network for Blood-Based Personalized Cancer Risk.

OBJECTIVE: To support cancer screening and identify precancerous conditions, such as atypical hyperplasia, to improve cure rates and reduce mortality,...

Apr 9 2026 42170495
Regulatory risk loci link disrupted androgen response to the pathophysiology of polycystic ovary syndrome.

A major challenge in deciphering the complex genetic landscape of polycystic ovary syndrome (PCOS) lies in the limited understanding of how susceptibi...

Apr 9 2026 41994484
Classification of biliary strictures using real-time cholangioscopy artificial intelligence: the SMART-AI trial.

BACKGROUND: Sampling techniques have poor accuracy for classifying biliary strictures as benign or malignant. Previously, a cholangioscopy artificial ...

Apr 9 2026 41966465
Comprehensive Assessment of Artificial Intelligence as a Stand-alone tool for Cervical Cancer Screening Using a 50% Negative Cutoff Value.

PURPOSE: An emerging application of artificial intelligence (AI) in cervical cytology is its use as an independent screener for triaging cases that do...

Apr 9 2026 41966523
Vocal Age Gap as a Noninvasive Biomarker for Early Detection of Laryngeal Cancer Using Deep Learning.

OBJECTIVES: Early vocal changes such as hoarseness or voice fatigue are common and often attributed to normal aging or benign conditions, which can de...

Apr 9 2026 41963165
Deep learning-driven recognition of panoramic tumor microenvironment features in H&E sections and its application.

The tumor microenvironment (TME), composed of tumor cells together with stromal cells, immune cells, vascular networks, and other components, constitu...

Apr 9 2026 41956540
Identification and experimental validation of aging-related biomarkers in intervertebral disc degeneration.

Intervertebral disc degeneration (IDD) is a prevalent disease with an increasing incidence, and aging is a key risk factor for its progression. Theref...

Apr 9 2026 41957266
Artificial intelligence in clinical oncology: Multimodal integration and translational development.

Artificial intelligence (AI) is rapidly reshaping clinical oncology, as cancer care increasingly relies on integrating heterogeneous data streams span...

Apr 8 2026 41962624
Integration of advanced ultrasound techniques, radiomics, and artificial intelligence for improved diagnosis of cystic breast lesions.

Cystic breast lesions are commonly encountered on breast ultrasound, encompassing a spectrum from simple benign cysts to complex mixed solid and cysti...

Apr 8 2026 41966528
Multi-omics and AI-guided discovery and validation of sisomicin as a COPA-targeting agent for pathological scar inhibition.

BACKGROUND: Pathological scars, including hypertrophic scars and keloids, are fibrotic skin disorders marked by excessive collagen deposition and pers...

Apr 8 2026 41980581
Digital Enabled Diagnosis System for Mammogram Images Classification Using Machine Learning.

Breast tumor is the most commonly detected tumors and remain one of the leading causes of cancer-related mortality among women worldwide. Although mam...

Apr 8 2026 41952302
Computerized diagnosis of brain tumor using graph based CNN classification.

Magnetic resonance imaging (MRI) is essential in the accurate diagnosis of brain tumors so that sound treatment planning can be done, however, clinica...

Apr 8 2026 41955752
Integrative assessment of sulfoxaflor effects on gene expression, reproduction, and behavior in the bumblebee Bombus impatiens.

Social insect pollinators, such as bumblebees, face increasing threats from environmental agrochemicals; yet the sublethal effects of these compounds ...

Apr 8 2026 41955849
Digital SERS Nanoprobe Immunoassay With Single-Particle Sensing Resolution for Detection of Pancreatic Cancer Biomarkers From Clinical Blood Samples.

Surface-enhanced Raman scattering (SERS) nanoprobe-based immunoassay is an emerging liquid biopsy modality for the detection of blood biomarkers. Howe...

Apr 8 2026 41947704
A practical framework for super-resolution of mass spectrometry images via adaptation of deep learning models.

Achieving high spatial resolution is critical for revealing tissue-specific metabolite distributions in mass spectrometry imaging (MSI), yet practical...

Apr 8 2026 41948959
Radiopathomic Graph Deep Learning for Multiscale Spatial-Contextual Modeling of Intratumoral Heterogeneity to Predict Breast Cancer Response to Neoadjuvant Therapy.

Purpose To develop an explainable radio-pathomic graph deep-learning (RPGDL) system for multiscale spatial-contextual modeling of intratumoral heterog...

Apr 8 2026 41949455
Development of an Integrated Deep Learning Approach for Detecting Fetal Brain Abnormalities in Routine Second Trimester Ultrasound Scan: A Multicenter Study.

Purpose To develop and validate an anatomy-aware, two-stage, end-to-end deep learning (DL) pipeline for fetal brain abnormality automated detection on...

Apr 8 2026 41949456
Integrated multi-omics and experimental validation for identifying novel biomarkers of acute myocardial infarction.

Acute myocardial infarction (AMI) remains a leading cause of morbidity and mortality, and early diagnosis and personalized therapy are constrained by ...

Apr 8 2026 41949600
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