Pathology

Latest AI and machine learning research in pathology for healthcare professionals.

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Digital holographic microscopy: use of artificial intelligence to enable rapid blood culture Gram stain digitization and interpretation.

Gram staining is one of the most commonly performed tests in the clinical microbiology laboratory. Results are used to both guide empiric antimicrobial therapy as well as downstream laboratory procedures, including culture workup. Despite its ubiquity, Gram staining is time-intensive, operator-dependent, and demands a rapid turnaround time. As such, it is an ideal target for automation. However, c...

Mar 30 2026 41910323

Concurrent AI-human interaction in prostate cancer MRI interpretation: More hype than help?

OBJECTIVE: We evaluated a commercial artificial intelligence (AI) system as a concurrent decision-support tool for clinically significant prostate cancer (csPCa) detection. MATERIALS AND METHODS: In our retrospective study, consecutive patients underwent multiparametric MRI for clinical suspicion of PCa. All scans were reviewed by six readers with varying expertise (two expert radiologists, > 1,00...

Mar 30 2026 41910833
Development of Machine Learning Models for Predicting Prostate Cancer in Biopsy Candidates Using Prostate-Specific Antigen, Magnetic Resonance Imaging, and Hematologic Parameters.

INTRODUCTION: Prostate-specific antigen (PSA) alone is insufficient for the diagnosis of prostate cancer (PCa), particularly within the gray zone rang...

Mar 30 2026 41911495
Thermal Decomposition Simulations of Hydroxylamine Pentazolate With Deep Neural Network Potential.

Against the backdrop of insufficient research into the microscopic reaction mechanisms of pentazole anion ( N 5 - $$ {\mathrm{N}}_5^{-} $$ ) salts...

Mar 30 2026 41891449
IGSF9 drives malignant transformation and predicts early-stage lung adenocarcinoma in integrated transcriptomic analyses.

PURPOSE: Lung adenocarcinoma (LUAD), the most common subtype of non-small cell lung cancer (NSCLC), often presents with mild or absent symptoms in its...

Mar 29 2026 41904745
Bulk and single-cell transcriptome analyses combined with molecular simulations identify ferritinophagy as a key target for resveratrol in osteoarthritis.

The pathophysiology of osteoarthritis (OA), a common degenerative joint disease, is complicated. The significance of autophagy irregularities and iron...

Mar 28 2026 41902854
Multiphysics learning with graph neural networks for thrombosis prediction in intracranial aneurysms.

Intracranial aneurysms are pathological dilations of cerebral arteries affecting 3-5% of the population. Their rupture can cause subarachnoid hemorrha...

Mar 28 2026 41905249
Machine learning classification of normal and malignant cells on the basis of their viscoelastic properties.

BACKGROUND AND OBJECTIVE: Cell mechanics, elasticity and viscoelasticity, are key markers of biological states like cancer. Atomic force microscopy (A...

Mar 27 2026 41936192
Deep transfer learning radiomics combined with explainable machine learning for predicting malignancy risk in parotid gland tumors based on ultrasound.

OBJECTIVE: This study aimed to develop and validate an ultrasound (US)-based deep transfer learning radiomics model, integrated with explainable machi...

Mar 27 2026 41991376
Whole-body molecular and cellular mapping of the laboratory mouse.

The laboratory mouse is a key model system for biomedical research, yet body-wide measurement tools are lacking. Here, we generate spatiotranscriptomi...

Mar 27 2026 41903540
Artificial intelligence-assisted three-dimensional imaging of breast microinvasive carcinoma reveals larger invasive focus size in a substantial proportion of cases.

Microinvasive carcinoma of breast is a unique type of malignancy characterized by the presence of small invasive foci (less than 1 mm in diameter) in ...

Mar 27 2026 41904044
Dental Odontogenic Lesion CBCT and Histopathology Integrated Dataset for Benchmarking Deep Learning Algorithms.

Accurate diagnosis of odontogenic lesions requires pre-operative cone-beam computed tomography (CBCT) and post-operative histopathological confirmatio...

Mar 27 2026 41896560
PTBD: a machine learning-based non-invasive diagnostic model for pulmonary tuberculosis using large-scale blood transcriptomes.

BACKGROUND: Accurate and rapid diagnosis is essential for controlling pulmonary tuberculosis (PTB) by enabling timely intervention and reducing diseas...

Mar 27 2026 41888771
Quantitative pathology and APOE genotype reveal dementia risk and progression in Lewy body disease.

Dementia in Lewy body diseases (LBD) is common and arises through heterogeneous and incompletely understood pathways. Evidence suggests contributions ...

Mar 27 2026 41889331
Artificial Intelligence for Colorectal Surgeons - Part I: Foundations, Clinical and Educational Applications.

BACKGROUND: Artificial intelligence (AI) is rapidly transforming colorectal surgery through applications spanning screening to postoperative care. Thi...

Mar 27 2026 41891368
Natural Language Processing Methods Automate Molecular Marker Extraction From Glioma Pathology Reports.

BACKGROUND AND OBJECTIVES: Molecular markers such as isocitrate dehydrogenase (IDH) and alpha-thalassemia/mental retardation syndrome X-linked (ATRX) ...

Mar 27 2026 41891708
Deep Learning Enables Pixel-Level Nanoparticle Distribution Mapping in Routine Histological Sections by Integrating Cancer Associated Fibroblasts Features.

The efficient accumulation and uniform distribution of nanomedicine within tumors are critical for achieving therapeutic outcomes. However, convention...

Mar 27 2026 41893882
Artificial Intelligence and Multiomics Beyond PSA Screening in African and Middle Eastern Prostate Cancer Patients.

Prostate cancer (PCa) remains a major global health burden, with incidence rising as populations age. The molecular, histological, and patient-specifi...

Mar 27 2026 41894385
Etiologic diagnosis of seasonal allergic rhinitis supported by artificial intelligence: the @IT-2020 project.

BACKGROUND: A precise etiological diagnosis of seasonal allergic rhinitis (SAR) is essential for a tailored prescription of its only curative treatmen...

Mar 26 2026 41903764
Deep learning assisted particle size ranking and estimation from SEM images without explicit segmentation.

In nanomaterial research, accurate determination of particle size and morphology from Scanning Electron Microscopy (SEM) images is a fundamental requi...

Mar 26 2026 41905154
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