Pathology

Artificial intelligence-assisted FTIR spectroscopy for hormone receptor subtyping in formalin-fixed breast Cancer tissues.

BACKGROUND: Determination of estrogen receptor (ER) and progesterone receptor (PR) status is critical for breast cancer subtyping and guiding endocrine therapy. Although immunohistochemistry (IHC) remains the diagnostic gold standard, it is costly, labor-intensive, and prone to interobserver variability. These limitations are particularly restrictive in low-resource settings where access to standa...

GHMS-CycleGAN: Graph-Based Hierarchical Multi-stain CycleGAN for Stain Normalization and Classification in Digital Pathology.

The emergence of digital pathology (DP) has provided numerous computer-aided diagnosis (CAD) opportunities and tools based primarily on deep learning (DL) approaches. However, staining variations and distortions caused by DP scanners during image digitization pose challenges and cause performance degradation in DL-based CAD systems. In this work, we introduce novel methods of stain and scan normal...

Physics-based simulation of ultrasound propagation from MRI volumes for cross-modal breast imaging.

BACKGROUND: Magnetic resonance imaging (MRI) of breast tissue is often used to definitively diagnose breast cancer due to its high soft-tissue contras...

Molecularly Engineered SERS Platform with Microturbulence-Enhanced Electrohydrodynamics for Multiplexed Profiling of Lung Cancer ctDNA.

Precise profiling of multiple circulating tumor DNA (ctDNA) is hindered by the challenge of resolving single-nucleotide variants (SNVs) and their trac...

Technical Description of the Mini Far-Lateral Approach: A Refined, Stability-Preserving Corridor to the Petroclival Region.

BACKGROUND AND OBJECTIVES: The far-lateral approach remains essential for accessing ventral and ventrolateral lesions of the craniovertebral junction....

Enhancing drug synergy in malignant diseases with deep architecture optimization algorithms.

Malignant diseases remain one of the leading causes of death globally. Drug synergy has emerged as an effective approach for treating malignancy, offe...

Artificial Intelligence and Nasal Cytology: Toward a Comprehensive Cytological Endotyping of Rhinitis.

Comparison of breast ultrasound image classification accuracy between convolutional neural networks and human experts using multicenter external validation cohort data.

PURPOSE: In recent years, much research has been conducted on ultrasound diagnosis of breast tumors using convolutional neural networks (CNNs). While ...

Contemporary Indications and Technical Limits of Transoral Laser Microsurgery for Laryngeal Squamous Cell Carcinoma.

Transoral laser microsurgery (TOLMS) is an established organ-preserving treatment for early-stage and selected intermediate-stage laryngeal squamous c...

A Deep Learning-Driven Framework Integrating Organoid-Based Functional Validation Identifies Universal Neoantigens from Recurrent Glioma Mutations.

Glioblastoma (GBM) is the most common malignant intracranial tumor in adults, with a median survival of only 16-20 months. Neoantigen therapy has show...

Prostate cancer tissue mapping and stratification using DRAQ5 and Eosin fluorescent labels integrated with AI classification and segmentation algorithms.

BACKGROUND: Fluorescent microscopy using the DRAQ5 and Eosin probes has been shown in the literature to be capable of producing rapid tissue character...

Quantitative regression of qFibrosis with resmetirom: Exploratory histologic endpoints from the MAESTRO-NASH phase III clinical trial.

BACKGROUND & AIMS: Resmetirom, a thyroid hormone beta (THR-β) agonist, has been shown to improve metabolic dysfunction-associated steatohepatitis (MAS...

Immune gene MMP9 as a potential key mediator in TCDD exposure-associated atherosclerosis: An integrated study based on network toxicology and experimental validation.

BACKGROUND: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a highly toxic, recalcitrant persistent organic pollutant with ubiquitous environmental dist...

Ultrasound Localization Microscopy Learned from power doppler by uncertainty frequency density estimation and semantic consistency awareness.

Ultrasound Localization Microscopy (ULM) achieves micron-level vascular visualization beyond the resolution of conventional ultrasound imaging by trac...

Unlocking azobenzene isomerization mechanisms via an LLM agent-driven workflow integrating simulation, experiment, and machine learning.

Bridged azobenzene derivatives are key photo-responsive molecular switches. However, probing and interpreting their microscopic Z ↔ E isomerization me...

Human microphysiological systems of aging recreate the in vivo process expediting evaluation of anti-geronic strategies.

The search for biological mechanisms of human aging is stalled by a lack of suitable models, and it remains unknown whether and to what degree rejuven...

Advanced imaging techniques for tumor intraoperative navigation imaging.

Cancer remains a leading cause of mortality and morbidity, with surgical resection being a fundamental element of treatment. However, early detection ...

Finding the most promising indications for novel treatments in oncology.

Tackling cancer with effective therapies is a major challenge our society faces with significant costs and complexities of designing and validating tr...

AI-Assisted Tissue Classification in Chironomus riparius: A Potential Tool for Ecotoxicological Studies.

Histological techniques are valuable tools in various biological and medical disciplines. They have proven particularly valuable in ecotoxicological s...

A Multimodal Attention Fusion-Based Model for Pathological Voice Detection.

Pathological voice detection provides a non-invasive and cost-effective approach for the early screening of laryngeal disorders. However, most existin...