Pathology

Latest AI and machine learning research in pathology for healthcare professionals.

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Diagnosis of Primary Open-Angle Glaucoma Using Spectral Profiling of Aqueous Humor-Derived Exosomes.

Primary open-angle glaucoma (POAG) is one of the most common neurodegenerative diseases that cause irreversible optic nerve damage. POAG diagnosis requires multimodal assessments; however, current methods like intraocular pressure (IOP) and optical coherence tomography (OCT) imaging suffer from low sensitivity and inter-patient variability, respectively. Liquid biopsy provides objective molecular ...

Feb 18 2026 41707013

Neuropathologic basis of quantitative susceptibility mapping in the substantia nigra: contributions of tau, pigmented neurons, and iron.

Quantitative susceptibility mapping (QSM) on MRI quantifies tissue magnetic susceptibility, which increases with iron accumulation, myelin loss, and neuroinflammation. Elevated QSM in the substantia nigra (SN) has been reported in Lewy body disease and other parkinsonian disorders, but from existing literature it remains unclear whether these findings are driven by neurodegeneration-related iron d...

Feb 18 2026 41708563
Identification of molecular diagnostic markers and potential therapeutic drugs for Sjögren's syndrome.

Sjögren's Syndrome (SS) is a long-term autoimmune disorder marked by damage to exocrine glands and irregularities in the immune system. Currently, the...

Feb 18 2026 41708714
Clinical-grade autonomous cytopathology through whole-slide edge tomography.

Cytopathology, often abbreviated as cytology, has a central role in the early detection of cancer, such as cervical, lung and bladder cancers, owing t...

Feb 18 2026 41708854
Identifying a fatty acid metabolic gene signature in diabetic cardiomyopathy through integrated bioinformatics and machine learning.

BACKGROUND: Diabetic cardiomyopathy (DCM) is a major cardiovascular complication of diabetes mellitus, ultimately progressing to heart failure and inc...

Feb 17 2026 41747444
Artificial intelligence application in routine pathology: ChatGPT-4.0 and Gemini 2.5 pro performance in detection of MMR-deficiency in colorectal cancer.

PURPOSE: Immunohistochemistry (IHC) is a crucial step in the diagnostic and therapeutic management of colorectal carcinoma (CRC). This study aimed to ...

Feb 17 2026 41722209
2D shape dataset of proximity-based spatial relation concepts.

Understanding how objects are positioned and related to each other in space is an important part of visual perception. Although people can recognize t...

Feb 17 2026 41815797
Development and multicenter validation of a predictive model for malignant pleural effusion recurrence.

Early prediction of malignant pleural effusion (MPE) recurrence within 3 months is essential for optimizing management in lung cancer patients. This s...

Feb 17 2026 41847612
The feasibility and accuracy of real-time intra-operative confocal tissue diagnosis in brain and spine cancer surgery.

Real-time intra-operative brain tumour tissue analysis can reduce turnaround times and enable repeated sampling, enhancing diagnostic accuracy and gui...

Feb 17 2026 41699335
Analysing DCE-MRI scans using hybrid techniques for early detection of prostate cancer based on fusion features of handcrafted and deep learning features.

Prostate cancer is among the most diagnosed malignancies in men worldwide and a leading cause of cancer-related mortality. Early and accurate diagnosi...

Feb 17 2026 41700925
Artificial intelligence-based smartphone application for skin cancer detection: A prospective diagnostic accuracy study.

BACKGROUND: Smartphone applications that use artificial intelligence (AI) for skin cancer diagnosis may assist in early detection. However, prospectiv...

Feb 17 2026 41701029
ERBB2 as a Prognostic Biomarker in Prostate Cancer: Integration of Single-Cell Transcriptomics, Deep Learning, and Immunohistochemical Validation.

Biochemical recurrence (BCR) is a critical factor affecting the prognosis of prostate cancer (PCa) patients, while T cell exhaustion and metastatic pr...

Feb 17 2026 41701406
Characterising processing conditions that artifactually bias human brain tissue transcriptomes.

Autopsy-derived brain tissue analysis is crucial for understanding neurobiology, but post-mortem handling can introduce artifacts. We studied adult hu...

Feb 17 2026 41702898
A Novel Approach to Ovarian Cancer Diagnosis via CT Imaging: GPT-4o-Driven Automated Feature Recognition and Validation in Clinical Settings.

BACKGROUND: Accurate non-invasive diagnosis of early-stage ovarian cancer remains challenging because of the limited number of biomarkers. Although ar...

Feb 17 2026 41703208
A Generative Foundation Model for Scalable Cytology Image Synthesis in AI-Powered Diagnostics.

PURPOSE: Cytology is a cornerstone of pathologic diagnosis. However, the use of artificial intelligence (AI) models for cytology-based diagnostics rem...

Feb 17 2026 41342884
Classification of small specimen uranium ores using LIBS combined with machine learning and deep learning algorithms.

In this study, classification models based on laser-induced breakdown spectroscopy (LIBS) technology, combined with machine learning (ML) and deep lea...

Feb 17 2026 41699974
AI-Enhanced Vibrational Capsule for Minimally Invasive Detection of Abnormal Bowel Tissue.

Colorectal cancer remains one of the leading causes of cancer mortality, and its prognosis is strongly dependent on early detection. Conventional diag...

Feb 17 2026 41700338
Analysis of passive bloodstain morphology across surface textures and drop heights using deep learning.

Bloodstain pattern analysis (BPA) is a critical forensic science tool for reconstructing crime scene events. In this study, the effect of substrate ty...

Feb 16 2026 41707408
Incorporating global-local tissue changes to predict future breast cancer from longitudinal screening mammograms.

Early detection of breast cancer (BC) through mammography screening is critical for reducing mortality and improving patient outcomes. However, full-p...

Feb 16 2026 41747525
Identification of pyroptosis-associated genes for the prediction of metabolic dysfunction-associated steatohepatitis based on interpretable machine learning models.

BACKGROUND: Pyroptosis, a pro-inflammatory form of regulated cell death mediated by gasdermin pore formation and typically triggered by inflammasome a...

Feb 16 2026 41722245
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