Pathology

Latest AI and machine learning research in pathology for healthcare professionals.

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MOTDNet: Multi organ task decoupling network for cell segmentation.

In histopathology, cell detection and segmentation of Hematoxylin and Eosin (H&E) stained tissue images are essential clinical tasks. Existing methods decompose cell segmentation into three tasks: nucleus shape capture, overlapping nucleus separation, and nucleus type identification. However, these methods use a same structure decoder for all three tasks, ignoring the unique characteristics of eac...

Mar 18 2026 41921258

Orthogonal disentanglement of single-cell multi-omics reveals private and shared drivers of tissue development and pathogenesis.

Characterizing gene expression and regulatory dynamics underlying both normal tissue function and disease progression requires an integrative analysis of single-cell multi-omics data. However, the asynchrony of gene regulation and the snapshot of single-cell multi-omics data give rise to private signals unique to each omics layer and shared signals reflecting cross-modality coordination. Here, we ...

Mar 18 2026 41849387
A multimodal biomechanics dataset with synchronized kinematics and internal tissue motions during reaching.

Tissue motions within body segments, such as the relative movements of muscles, fascia, and bone, remain largely unexplored despite their relevance to...

Mar 18 2026 41851191
Identification of hypoxia-related gene signatures and molecular subtypes in chronic rhinosinusitis with nasal polyps.

OBJECTIVES: Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) is a common and severe subtype of Chronic Rhinosinusitis (CRS), characterized by persist...

Mar 18 2026 41855680
Proteomics in tissue regeneration: insights into protein alterations and post-translational modifications during healing.

Tissue regeneration is a complex, multi-phase process orchestrated by dynamic changes in protein expression and post-translational modifications (PTMs...

Mar 18 2026 41848587
A Scoping Review of Machine Learning Applications for Diagnosis, Classification, and Prognosis in Lupus Nephritis.

BACKGROUND: Over the past decade, machine learning (ML) has transformed histopathology, yet its application in lupus nephritis (LN) remains underexplo...

Mar 18 2026 41848794
An artificial intelligence-powered digital pathology platform to support large-scale deworming programs against soil-transmitted helminthiasis and intestinal schistosomiasis in resource-limited settings.

BACKGROUND: The World Health Organization (WHO) has emphasised the need for innovative diagnostic tools to support the control and elimination of negl...

Mar 18 2026 41849369
Detection of Non-diabetic Kidney Disease in Patients with Diabetes Using Machine Learning and Electronic Medical Record Data.

INTRODUCTION: The identification of non-diabetic kidney disease (NDKD) in diabetic patients is critically important. Unlike diabetic nephropathy, NDKD...

Mar 18 2026 41849636
Token-guided multimodal prognosis in hepatocellular carcinoma: a framework steered by tumour-stroma ratio.

BACKGROUND: The tumour-stroma ratio (TSR) is a potential prognostic indicator, yet hindered by quantification challenges and conflicting reports. OBJE...

Mar 18 2026 41850702
Exosomes in diabetic kidney disease: pathogenesis, biomarker discovery, and emerging therapeutics-a comprehensive systematic review.

Diabetic kidney disease (DKD), characterized by progressive renal dysfunction, is a prevalent microvascular complication of diabetes mellitus and a le...

Mar 17 2026 41845912
High confidence Raman spectroscopy of tumor biomarker proteins through experimental and theoretical cross-validation.

Cancer represents a significant challenge to people's health and safety. Tumor biomarker detection plays a vital role in the precise diagnosis of canc...

Mar 17 2026 41863219
Artificial intelligence-enhanced virtual reality for pathology education.

The implementation of innovative active learning pedagogies in education enhances students' engagement and information retention compared to tradition...

Mar 17 2026 41875780
Automated phenotyping of mammary gland tissues using computer vision systems.

Quantifying mammary gland tissue composition is crucial for understanding growth patterns and future lactation potential in dairy heifers, yet convent...

Mar 17 2026 41850381
dMMR prediction from colorectal cancer histopathology: Leveraging non-tumor and low-magnification regions.

BACKGROUND AND OBJECTIVE: Colorectal cancer is the second leading cause of cancer-related mortality worldwide, posing a substantial burden on healthca...

Mar 17 2026 41875848
Discrimination of vascular proliferation in eyelid surgery using multimodal hyperspectral imaging technology.

BACKGROUND AND OBJECTIVE: Vascular proliferation is a common skin reaction following eyelid surgery, and early diagnosis is crucial for improving trea...

Mar 17 2026 41905157
LymphUs: A multicenter open-access database of lymph node ultrasound images in patients with papillary thyroid carcinoma for clinical and artificial intelligence research.

Approximately 30-50% of Papillary thyroid carcinoma (PTC) patients develop cervical lymph nodes (LNs) metastasis, significantly increasing the risk of...

Mar 17 2026 41940127
Three-dimensional high-content imaging of unstained soft tissue with subcellular resolution using a laboratory-based X-ray microscope.

With increasing interest in studying biological systems across spatial scales-from centimeters down to nanometers-histology continues to be the gold s...

Mar 17 2026 41843669
Impact of data space augmentation strategy on model accuracy and generalization in thin-section rock classification.

The growing importance of machine learning in geological data computing, as well as in the broader geoscience and energy sectors, makes it essential t...

Mar 17 2026 41844765
Multi-dimensional deep learning-based segmentation and volumetric assessment of sphenoid sinus fluid on postmortem CT in drowning cases.

Sphenoid sinus fluid is considered a supportive indicator of drowning in forensic medicine, but traditional manual assessment on postmortem computed t...

Mar 17 2026 41844778
AI-based modeling of treatment decisions in benign prostatic hyperplasia: a transformer-based comparative study.

Benign Prostatic Hyperplasia (BPH) is a common condition among aging men that often causes significant urinary symptoms, impacting their quality of li...

Mar 17 2026 41845421
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