Pathology

Exploring the molecular mechanism of Shenling baizhu formula in the treatment of ulcerative colitis via the cGMP-PKG signaling pathway.

ETHNOPHARMACOLOGICAL RELEVANCE: Ulcerative colitis (UC) is a chronic inflammatory bowel disease char...

Artificial intelligence in microscopic hair imaging for scalp disorders: From image acquisition to clinical decisions.

Medical imaging plays a central role in modern clinical decision-making by transforming raw image da...

CRISPR-Cas12a/Cas13a in cancer molecular diagnosis.

Cancer remains a leading cause of global mortality, with early diagnosis being pivotal for improving...

The Right Ventricle, the Forgotten Chamber or Not.

Right ventricular (RV) enlargement or dysfunction evaluation is the cornerstone for diagnosis, progn...

Nitenpyram promotes breast cancer progression via PARP1: Integration of multi-omics analyses with experimental validation.

Nitenpyram (NIT) is an insecticide used primarily for flea control in pets, especially cats and dogs...

Incremental learning approach for semantic segmentation of skin histology images.

This study presents an incremental learning framework to enhance the generalization and robustness o...

Machine Learning-Integrated Pharmacophore, DFT Analysis, and molecular dynamics of Diosmetin as a potent ache inhibitor with neuroprotective activity in a Scopolamine-Induced alzheimer's zebrafish model.

Alzheimer's Disease (AD) is a degenerative disorder of the brain that causes a gradual loss of cogni...

Lanthanide-Doped Organic Framework Sensor Array Coupled with Machine Learning for Minimally Invasive Glioma Diagnosis via Cerebrospinal Fluid Biopsy.

Glioblastoma multiforme (GBM), the most malignant subtype of glioma, poses significant diagnostic ch...

Enhancing Early Detection of Contralateral Breast Cancer in Breast Cancer Survivors Using AI-Assisted Mammography.

BACKGROUND: Women with a history of breast cancer face an elevated risk of developing contralateral ...

Clinical development of molecular residual disease (MRD) and multi-cancer early detection (MCED) using liquid biopsy multiomics with artificial intelligence (AI).

BACKGROUND: Early detection of cancer and precise recurrence monitoring remain major unmet needs in ...

The DNA-Based Disease Diagnosis Model with Strand Displacement Reaction.

MicroRNAs (miRNAs) serve as crucial biomarkers in disease diagnosis. Although silicon-based electron...

Radiomics-based ultrasOund Model for differentiating Uterine Sarcomas from leiomyomas (ROMUS): a retrospective pilot Multicenter Italian Trials in Ovarian Cancer (MITO) study.

OBJECTIVE: To develop machine-learning models that incorporate clinical information and radiomics fe...

Fragmentomic liquid biopsy enables early breast cancer detection, molecular subtyping and lymph node assessment.

Breast cancer remains a leading global health concern in women, while screening is still limited by ...

Percutaneous nephrostomy guidance by a convolutional-neural-network-based optical coherence tomography endoscope.

Percutaneous nephrostomy is widely used in kidney access surgeries. Despite its prevalence in urolog...

A confidence-based, artificial intelligence pathology model for diagnosis of intrahepatic cholangiocarcinoma.

BACKGROUND: Intrahepatic cholangiocarcinoma (ICCA) is a rare but highly lethal adenocarcinoma arisin...

Deep Learning-Derived Body Composition Analysis Predicts Long-Term Mortality After Transcatheter Aortic Valve Replacement.

OBJECTIVE: To examine the association between body composition metrics derived from preprocedural co...

Artificial Intelligence-based Gram Stain Classification: Accuracy and Clinical Utility in Positive Blood Cultures.

INTRODUCTION: With the rapid advancement of artificial intelligence (AI) technology, AI has been app...

Unraveling the connection between PFOA and bladder cancer: A study integrating network toxicology, molecular docking, and experimental validation.

PFOA, an environmental pollutant linked to bladder cancer, has unclear molecular mechanisms. Integra...

Advances in the application of photodynamic diagnosis in Skin Tumors.

Photodynamic Diagnosis (PDD) is a non-invasive imaging technique. It relies on a photosensitizer tha...

CLWD: a Chinese histopathology dataset for lung adenocarcinoma subtype classification.

Effective diagnosis and treatment of lung adenocarcinoma depends on accurate typing, subtyping, and ...

Deep learning-based histopathological classification and subclassification of benign and malignant salivary gland tumors.