Pathology

Meta learning optimized TabNet for small sample repeat prostate biopsy prediction.

PURPOSE: Repeat prostate biopsy prediction remains limited by small patient cohorts that constrain artificial intelligence application despite theoretical advantages in capturing complex clinical patterns. This study develops and validates a meta-learning optimized TabNet framework using readily available clinical parameters to overcome sample size constraints and enhance repeat biopsy (RB) predic...

Leveraging proteomics and machine learning for mechanism and biomarker discovery on glioma progression and transformation: from LGG to GBM.

BACKGROUND: Glioma was the most common malignant tumor of the central nervous system in adults. Low-grade gliomas (LGGs) have a potential of grade progression and histological transformation, and the relevant mechanisms of this malignant evolution were still unclear. METHODS: In this study, we used 61 primary-recurrent paired glioma samples from 28 patients for proteomics analysis based upon DIA-N...

A targeted proteomics assay for the preoperative diagnosis of thyroid nodules.

Accurate preoperative diagnosis of thyroid nodules via fine-needle aspiration (FNA) biopsy remains challenging, particularly in cases with indetermina...

Artificial synaptic behaviors of a mobile silver-doped vanadium-cerium oxide memristor with embedded silver nanoclusters for neuromorphic computing applications.

Although mobile metal-ion-based filamentary memristors are explored as an artificial synapse for neuromorphic computing, they suffer from abrupt and s...

Machine learning-based prognostic prediction for cutaneous malignant melanoma patient survival.

BACKGROUND: Cutaneous malignant melanoma (CMM) is a highly malignant tumor that necessitates early diagnosis and precise survival prediction. The deve...

Clinical Validation of AI-assisted Evaluation of Indeterminate Biliary Strictures in Digital-Single Operator Cholangioscopy: a Transcontinental Multicentric Study.

INTRODUCTION: Biliary strictures (BS) are a significant challenge, with malignant strictures frequently diagnosed at advanced stages, limiting curativ...

Integrated and Ultrafast Multiomics Sample Preparation Workflow for Screening Biomarker Panel of Platelet Biomolecules for Early Diagnosis of HCC.

Early detection of hepatocellular carcinoma (HCC) remains a persistent worldwide challenge. Owing to its minimal invasiveness, liquid biopsy has emerg...

Enhanced Transcytosis and Retention (ETR) of Drug Delivery Nanocarrier in Solid Tumors.

ConspectusTranscytosis, traditionally regarded as biological, constitutes an intrinsic and powerful pathway for macromolecule transport across endothe...

Synergy between Charge Transfer and Spatial Descriptors in Determining the Band Gap of hP4-Na: An Interpretable Machine Learning Approach.

Electrides are a class of materials whose highly localized electrons in the lattice interstices exhibit anion-like behavior, known as interstitial qua...

Investigating the Effect of Hospital Infection Control Informatization on Optimizing Microbiological Specimen Submission Before Antibiotic Therapy: Failure Mode and Effects Analysis.

BACKGROUND: Antimicrobial resistance (AMR) poses a critical global health threat, with inappropriate antibiotic use being a major driver. Timely micro...

Machine learning and logistic regression in estimating survival in patients with high-malignant deep-seated soft tissue sarcomas: development and analysis based on a population-based retrospective cohort.

BACKGROUND AND PURPOSE:  Soft tissue sarcomas are a heterogeneous group of malignant tumors with a high risk of metastasis, primarily to the lungs, ma...

Quantification of Ki-67 labeling index in pediatric brain tumor immunohistochemistry images.

Quantification of the Kiel 67 (Ki-67) labeling index (LI) is critical for assessing proliferation and prognosis in tumors but manual scoring remains a...

A nine-gene diagnostic model for IgA nephropathy based on multi-cohort machine learning: integrating gene expression and immunohistochemical validation.

IgA nephropathy (IgAN) is the most common primary glomerulonephritis, requiring improved diagnostic tools. We analyzed three cohorts (GSE37460, GSE937...

Pathology Public Datasets for Artificial Intelligence: A Systematic Review.

Histopathology plays a crucial role in the diagnosis of many diseases, especially cancers, for which the correct classification of tissue samples sign...

Multiphase CT-based deep learning radiomics nomogram models for preoperative WHO/ISUP grading of clear cell renal cell carcinoma: a two-center validation study.

BACKGROUND: Preoperative determination of clear cell renal cell carcinoma (ccRCC) World Health Organization/International Society of Urological Pathol...

Revolutionizing hepatic fibrosis staging: A machine learning approach combining clinical, biochemical, and microbiome insights.

Non-alcoholic Steatohepatitis (NASH) is a common disease that not only affects adults but has also been seen to affect all ages. This includes young a...

Effect of a Computer-Aided Device for Detecting Gastric Neoplasms: A Multicenter, Randomized Controlled Trial.

BACKGROUND & AIMS: Evidence about the effect of artificial intelligence (AI) on upper endoscopy in multicenter, randomized controlled trials is lackin...

LRF-UNet: Low-Rank Factorized Convolution Deep-Learning Networks for Visceral Adipose and Muscle Tissue Segmentation in Abdominal Computed Tomography Image.

Quantitative analysis of skeletal muscle (SM) and visceral adipose tissue (VAT) cross-sectional volumes at the third lumbar vertebral level (L3) on ab...

Position Paper: IOlBD Evidence-based Consensus on the Use of Artificial Intelligence for Assessment of Endoscopic and Histologic Endpoints in Clinical Trials of Inflammatory Bowel Disease.

BACKGROUND & AIMS: Central reading of endoscopy and histopathology is the current standard for disease activity assessment in inflammatory bowel disea...

Combined hepatocellular-cholangiocarcinoma: a contemporary pathologic and molecular perspective.

Combined hepatocellular cholangiocarcinoma (cHCC-CCA) is a rare primary liver carcinoma characterized by the unequivocal coexistence of hepatocytic an...