Pathology

Latest AI and machine learning research in pathology for healthcare professionals.

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Integrating machine learning with SHAP to uncover multi-tissue molecular signatures in Osteoarthritis progression.

Osteoarthritis (OA) is a chronic joint disorder characterized by pain, reduced mobility, and structural degeneration. Despite its complex etiology and multi-tissue involvement, the molecular mechanisms underlying OA remain poorly understood. This study aimed to identify tissue-specific diagnostic biomarkers using an integrative framework combining multiple machine learning (ML) algorithms and SHap...

Mar 9 2026 41801977

Frequency-Aware Feature Fusion Driven Multimodal Cell Microscopic Image Segmentation Framework.

Multimodal cell microscopic image segmentation is a core component of high-content imaging and analysis (HCIA) technology, and its segmentation accuracy directly impacts the precision of HCIA analysis results. Deep learning-based cell segmentation methods have been widely applied due to their end-to-end nature. However, when processing multimodal cell microscopy images, challenges such as missed c...

Mar 8 2026 41797365
[Standardizing breast cancer digital pathology databases for artificial intelligence: practice and reflection].

The traditional paradigm of pathology diagnosis faces challenges like data fragmentation and inefficiency in the era of big data and artificial intell...

Mar 8 2026 41795984
Estimating proton density fat fraction using computed tomography attenuation in skeletal muscle and adipose tissue in a prospective clinical cohort.

BACKGROUND: Proton density fat fraction (PDFF) measured using magnetic resonance imaging (MRI) is considered a noninvasive reference measure of fat de...

Mar 7 2026 41802496
Increased Prevalence of Extrathymic Neoplasms in Myasthenia Gravis Patients-A Population-Based, Matched Case-Control Study.

INTRODUCTION/AIMS: Myasthenia gravis (MG) is associated with thymic neoplasms. However, an increased prevalence of extrathymic neoplasms has also been...

Mar 7 2026 41795172
Artificial Intelligence-Based Pathological Subtype Diagnosis of Nasal Polyps: A Multidimensional and Micro-Visualization Study.

BACKGROUND: Nasal polyps (NP) are common upper respiratory conditions with diverse inflammatory subtypes influencing clinical features and prognosis. ...

Mar 7 2026 41795193
Adaptive diagnostic reasoning framework for pathology with multimodal large language models.

BACKGROUND: Artificial intelligence enhances pathology screening efficiency, yet clinical adoption remains limited because most systems operate as opa...

Mar 7 2026 41794962
Microscopic detection of nematodes in entomopathogenic nematode-enriched samples using a lightweight deep learning model.

Automated detection of entomopathogenic nematodes (EPNs) is increasingly important in biological control research, where manual microscopic counting r...

Mar 6 2026 41796953
Exploring the molecular mechanism of Shenling baizhu formula in the treatment of ulcerative colitis via the cGMP-PKG signaling pathway.

ETHNOPHARMACOLOGICAL RELEVANCE: Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by symptoms such as persistent diarrhea....

Mar 6 2026 41796620
Artificial intelligence in microscopic hair imaging for scalp disorders: From image acquisition to clinical decisions.

Medical imaging plays a central role in modern clinical decision-making by transforming raw image data into actionable diagnostic insights. In the con...

Mar 6 2026 41818862
CRISPR-Cas12a/Cas13a in cancer molecular diagnosis.

Cancer remains a leading cause of global mortality, with early diagnosis being pivotal for improving treatment outcomes. Traditional tissue biopsy is ...

Mar 6 2026 41796733
The Right Ventricle, the Forgotten Chamber or Not.

Right ventricular (RV) enlargement or dysfunction evaluation is the cornerstone for diagnosis, prognostications, and treatment planning in a variety o...

Mar 6 2026 42002386
Nitenpyram promotes breast cancer progression via PARP1: Integration of multi-omics analyses with experimental validation.

Nitenpyram (NIT) is an insecticide used primarily for flea control in pets, especially cats and dogs. Some studies suggest that NIT is associated with...

Mar 6 2026 41793917
Incremental learning approach for semantic segmentation of skin histology images.

This study presents an incremental learning framework to enhance the generalization and robustness of transformer-based deep learning models for segme...

Mar 6 2026 41786800
Machine Learning-Integrated Pharmacophore, DFT Analysis, and molecular dynamics of Diosmetin as a potent ache inhibitor with neuroprotective activity in a Scopolamine-Induced alzheimer's zebrafish model.

Alzheimer's Disease (AD) is a degenerative disorder of the brain that causes a gradual loss of cognitive function. The cholinergic hypothesis suggests...

Mar 6 2026 41787135
Lanthanide-Doped Organic Framework Sensor Array Coupled with Machine Learning for Minimally Invasive Glioma Diagnosis via Cerebrospinal Fluid Biopsy.

Glioblastoma multiforme (GBM), the most malignant subtype of glioma, poses significant diagnostic challenges due to limitations in current methods, su...

Mar 6 2026 41789540
Enhancing Early Detection of Contralateral Breast Cancer in Breast Cancer Survivors Using AI-Assisted Mammography.

BACKGROUND: Women with a history of breast cancer face an elevated risk of developing contralateral breast cancer (CBC). Although annual mammographic ...

Mar 6 2026 41790156
Clinical development of molecular residual disease (MRD) and multi-cancer early detection (MCED) using liquid biopsy multiomics with artificial intelligence (AI).

BACKGROUND: Early detection of cancer and precise recurrence monitoring remain major unmet needs in oncology. Conventional screening is limited to a f...

Mar 6 2026 41790338
The effect of neoadjuvant therapy on radiological, surgical, and pathological results in nonmetastatic breast cancer: A retrospective observational study.

The aim of the study was to evaluate the concordance between radiological imaging modalities and pathological findings and to test whether neoadjuvant...

Mar 6 2026 41790702
The DNA-Based Disease Diagnosis Model with Strand Displacement Reaction.

MicroRNAs (miRNAs) serve as crucial biomarkers in disease diagnosis. Although silicon-based electronic machine learning models provide efficient means...

Mar 6 2026 41790822
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