Latest AI and machine learning research in pathology for healthcare professionals.
Lung squamous cell carcinoma (LUSC) has a poor prognosis due to the lack of effective targeted therapies, and its incidence has increased dramatically in recent years, creating an urgent need for new prognostic markers. Given that tumor immune and metabolic heterogeneity can influence LUSC prognosis, this study aimed to construct a novel predictive model based on immune-related and metabolism-rela...
BACKGROUND: Lymph node (LN) metastasis is a well-established independent prognostic factor in head and neck squamous cell carcinoma (HNSCC). Formation of suppressive tumour immune microenvironment (TIME) is a major contributor to tumour immune evasion and metastasis. However, the TIME landscape underlying LN-metastatic HNSCC remains poorly elucidated. METHODS: A total of 688 866 single-cell transc...
INTRODUCTION: While current blood-based biomarkers for Alzheimer's disease (AD) are effective for determining amyloid beta (Aβ) pathology positivity/n...
BACKGROUND: Peri-operative blood transfusion is common during solid-organ transplantation, yet the impact of ABO-incompatible (ABOi) blood exposure on...
BACKGROUND: Lung cancer has been one of the leading causes of death in the world for decades. An effective computer-aided diagnosis (CAD) scheme for l...
BACKGROUND: Accurate needle placement is essential for prostate biopsy. Recently, transperineal prostate biopsies are receiving renewed interest due t...
BACKGROUND: Preservatives, widely used in food and skincare products, may influence prostate cancer (PCa) development. This study explores the effects...
OBJECTIVE: Disulfidptosis is a newly recognized form of regulated cell death characterized by actin cytoskeleton collapse under disulfide stress. Rece...
Diabetic kidney disease (DKD) is the primary cause of end-stage renal disease globally, yet reliable biomarkers for its diagnosis and progression asse...
BACKGROUND: T helper 17 (Th17) cells participate in all pathological stages of systemic sclerosis (SSc). Molecular markers associated with Th17 cells ...
BACKGROUND: Polycystic ovary syndrome (PCOS) and ischemic cardiomyopathy (ICM) share metabolic and cardiovascular risk factors, including insulin resi...
R-loops are dynamic nucleic acid structures implicated in genome regulation and instability, yet their contributions to the tumor microenvironment (TM...
The integration of artificial intelligence, protein engineering, and sustainable nanomedicine is driving a paradigm shift in theranostics by enabling ...
Photoacoustic computed tomography (PACT) reconstructs high-resolution images of various chromophores in deep biological tissue. A key to high-quality ...
RATIONALE & OBJECTIVE: Nearly 20% of deceased donor kidneys in the United States are placed "out-of-sequence" (ie, outside of standard allocation rule...
Industrial solid wastes are increasingly used as alternative feedstocks for synthesising sulfoaluminate cement (SAC). However, their complexity in com...
BACKGROUND: Immune cell infiltration in the renal interstitium contributes to the progression of diabetic nephropathy (DN), yet the precise mechanisms...
OBJECTIVES: Prostate cancer (PCa) diagnosis is increasingly guided by imaging, with ultrasound (US) emerging as a cost-effective and widely accessible...
Studying how actin filaments are assembled into different subcellular structures can provide insights into both physiological processes and the mechan...
Osteosclerotic jaw lesions, often incidentally detected on routine radiographs, are rarely biopsied due to their benign appearance and proximity to de...