Pediatrics

Latest AI and machine learning research in pediatrics for healthcare professionals.

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MethylationToActivity: a deep-learning framework that reveals promoter activity landscapes from DNA methylomes in individual tumors.

Although genome-wide DNA methylomes have demonstrated their clinical value as reliable biomarkers for tumor detection, subtyping, and classification, their direct biological impacts at the individual gene level remain elusive. Here we present MethylationToActivity (M2A), a machine learning framework that uses convolutional neural networks to infer promoter activities based on H3K4me3 and H3K27ac e...

Jan 19 2021 33461601

Development and validation of a deep-learning-based pediatric early warning system: A single-center study.

BACKGROUND: Early detection and prompt intervention for clinically deteriorating events are needed to improve clinical outcomes. There have been several attempts at this, including the introduction of rapid response teams (RRTs) with early warning scores. We developed a deep-learning-based pediatric early warning system (pDEWS) and validated its performance.

Jan 18 2021 35418352
Retrospective motion artifact correction of structural MRI images using deep learning improves the quality of cortical surface reconstructions.

Head motion during MRI acquisition presents significant challenges for neuroimaging analyses. In this work, we present a retrospective motion correcti...

Jan 15 2021 33460797
Development of a machine learning model for predicting pediatric mortality in the early stages of intensive care unit admission.

The aim of this study was to develop a predictive model of pediatric mortality in the early stages of intensive care unit (ICU) admission using machin...

Jan 13 2021 33441845
A deep learning framework for F-FDG PET imaging diagnosis in pediatric patients with temporal lobe epilepsy.

PURPOSE: Epilepsy is one of the most disabling neurological disorders, which affects all age groups and often results in severe consequences. Since mi...

Jan 9 2021 33420912
Convolutional Neural Networks for Pediatric Refractory Epilepsy Classification Using Resting-State Functional Magnetic Resonance Imaging.

OBJECTIVE: This study aims to evaluate the performance of convolutional neural networks (CNNs) trained with resting-state functional magnetic resonanc...

Jan 6 2021 33418117
A Novel Machine Learning Framework for Comparison of Viral COVID-19-Related Sina Weibo and Twitter Posts: Workflow Development and Content Analysis.

BACKGROUND: Social media plays a critical role in health communications, especially during global health emergencies such as the current COVID-19 pand...

Jan 6 2021 33326408
AI for Improving Children's Health: A Community Case Study.

The Indian health care system lacks the infrastructure to meet the health care demands of the country. Physician and nurse availability is 30 and 50% ...

Jan 6 2021 33733204
Early response to SPN-812 (viloxazine extended-release) can predict efficacy outcome in pediatric subjects with ADHD: a machine learning post-hoc analysis of four randomized clinical trials.

Machine learning (ML) was used to determine whether early response can predict efficacy outcome in pediatric subjects with ADHD treated with SPN-812. ...

Jan 5 2021 33418457
The impact of errors in infant development: Falling like a baby.

What is the role of errors in infants' acquisition of basic skills such as walking, skills that require immense amounts of practice to become flexible...

Jan 4 2021 33278863
Artificial Intelligence, Social Media and Depression. A New Concept of Health-Related Digital Autonomy.

The development of artificial intelligence (AI) in medicine raises fundamental ethical issues. As one example, AI systems in the field of mental healt...

Jan 4 2021 33393864
Retraining Convolutional Neural Networks for Specialized Cardiovascular Imaging Tasks: Lessons from Tetralogy of Fallot.

Ventricular contouring of cardiac magnetic resonance imaging is the gold standard for volumetric analysis for repaired tetralogy of Fallot (rTOF), but...

Jan 4 2021 33394116
The diagnosis of tuberculous meningitis in adults and adolescents: protocol for a systematic review and individual patient data meta-analysis to inform a multivariable prediction model.

Tuberculous meningitis (TBM) is the most lethal and disabling form of tuberculosis. Delayed diagnosis and treatment, which is a risk factor for poor ...

Jan 4 2021 33585702
Integrated meta-analysis and machine learning approach identifies acyl-CoA thioesterase with other novel genes responsible for biofilm development in Staphylococcus aureus.

Biofilm forming Staphylococcus aureus is a major threat to the health-care industry. It is important to understand the differences between planktonic ...

Jan 1 2021 33388440
Artificial Intelligence Model of Drive-Through Vaccination Simulation.

Planning for mass vaccination against SARS-Cov-2 is ongoing in many countries considering that vaccine will be available for the general public in the...

Dec 31 2020 33396526
The Potential and the Limitations of Esophageal Robotic Surgery in Children.

INTRODUCTION:  There have been numerous reports of robotic pediatric surgery in the literature, particularly regarding urological procedures for schoo...

Dec 30 2020 33378777
Porphyrin-based covalent organic framework as bioplatfrom for detection of vascular endothelial growth factor 165 through fluorescence resonance energy transfer.

A fluorescent aptasensor based on porphyrin-based covalent organic framework (p-COF) and carbon dots (CDs) was constructed for detecting vascular endo...

Dec 30 2020 33773722
Semi-supervised learning for somatic variant calling and peptide identification in personalized cancer immunotherapy.

BACKGROUND: Personalized cancer vaccines are emerging as one of the most promising approaches to immunotherapy of advanced cancers. However, only a sm...

Dec 30 2020 33375939
DetexNet: Accurately Diagnosing Frequent and Challenging Pediatric Malignant Tumors.

The most frequent extracranial solid tumors of childhood, named peripheral neuroblastic tumors (pNTs), are very challenging to diagnose due to their d...

Dec 29 2020 32991280
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