Pediatrics

Latest AI and machine learning research in pediatrics for healthcare professionals.

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Immune2V: Image Immunization Against Dual-Stream Image-to-Video Generation

Image-to-video (I2V) generation has the potential for societal harm because it enables the unauthorized animation of static images to create realistic deepfakes. While existing defenses effectively protect against static image manipulation, extending these to I2V generation remains underexplored and non-trivial. In this paper, we systematically analyze why modern I2V models are highly robust again...

Apr 12 2026 2604.10837v1

Developmental brain age gap in prematurity and postnatally emerging delay in congenital heart disease

Brain development follows a precisely regulated biological timetable, with defined periods of vulnerability increasingly recognized in congenital disorders affecting early brain development. This biological timing can be captured by the emerging concept of brain age, a measure of brain maturation, enabling the detection of deviation from normative developmental trajectories. Clinical conditions af...

Development and validation of an XGBoost model with SHAP-based interpretability and a web-based calculator for predicting extrauterine growth restriction in preterm infants

Background: Extrauterine growth restriction (EUGR) is a common and clinically significant complication among preterm infants, contributing to adverse ...

Predicting COVID-19 incidence from seroprevalence and population-based cohort data using interpretable machine learning with differential privacy analysis

During the COVID-19 pandemic, reported incidence data played a central role in public health surveillance and in tracking epidemic dynamics, although ...

Predicting long-term adverse outcomes after neonatal intensive care

Neonates requiring intensive care are at increased risk for long-term neuropsychiatric disorders. However, clinical adoption of risk prediction models...

Learning Patient-Specific Event Sequence Representations for Clinical Process Analysis

Healthcare system performance evaluation is constrained by episodic performance indicators and process mining techniques that fail to accommodate the ...

MAMGL: A memory-augmented meta-graph learning framework for adolescent major depression disorder diagnosis

Adolescent major depressive disorder (AMDD) is a prevalent and heterogeneous psychiatric condition that emerges during a critical period of brain deve...

Physics-Embedded Feature Learning for AI in Medical Imaging

Deep learning (DL) models have achieved strong performance in an intelligence healthcare setting, yet most existing approaches operate as black boxes ...

Mar 30 2026 2603.28057v1
Benchmarking single cell transcriptome matching methods for incremental growth of cell atlases

Background: The advancement of single cell technologies has driven significant progress in constructing a multiscale, pan-organ Human Reference Atlas ...

Evaluating Interactive 2D Visualization as a Sample Selection Strategy for Biomedical Time-Series Data Annotation

Reliable machine-learning models in biomedical settings depend on accurate labels, yet annotating biomedical time-series data remains challenging. Alg...

Mar 27 2026 2603.26592v1
Towards clinical implementation of artificial intelligence in cancer care: Concept mapping analysis of provincial workshop findings

Background: Artificial intelligence (AI) has rapidly garnered interest in healthcare, with research showing promise to improve quality, efficiency, an...

Data Diversity vs. Model Complexity in the Prediction of Pediatric Bipolar Disorder: Evidence from Academic and Community Clinical Samples

Pediatric bipolar disorder is challenging to diagnose accurately due to symptom heterogeneity. More standardized and data-driven approaches are needed...

Narcolepsy Revolution - Protocol and Methodology A diagnostic accuracy study protocol using the Dreem 3 headband for ambulatory diagnosis of narcolepsy in children and young adults

Background Narcolepsy is a rare, lifelong neurological disorder that often begins in childhood or adolescence. Diagnosis is frequently delayed because...

Methods for Knowledge Graph Construction from Text Collections: Development and Applications

Virtually every sector of society is experiencing a dramatic growth in the volume of unstructured textual data that is generated and published, from n...

Mar 26 2026 2603.25862v1
Self-supervised learning for a gene program-centric view of cell states

Single-cell omics has extended the biological interrogation of cell state from examining the expression of individual genes to unbiased profiling of t...

Utility of 3D Facial Analysis As A Biomarker In Rare Diseases Exploration with Hereditary Angioedema

Importance: People living with rare diseases (PLWRD) often face significant challenges in receiving timely and accurate diagnoses, leading to what is ...

Longitudinal Digital Phenotyping for Early Cognitive-Motor Screening

Early detection of atypical cognitive-motor development is critical for timely intervention, yet traditional assessments rely heavily on subjective, s...

Mar 26 2026 2603.25673v1
Human-supervised, large language model-based clinical decision support aligned to national newborn protocols in Kenya: a pragmatic, early-stage evaluation

Introduction: Timely, protocol-adherent clinical decisions are crucial for reducing neonatal mortality in low-resource settings. Translating extensive...

From Concept to Clinic: Real World Evidence for Autonomous AI Deployment in Primary Care Telemedicine

Systems powered by large language models are widely used for health information and advice, yet robust evidence for their safety and effectiveness in ...

A Novel Dual-Outcome Risk Calculator for Trial of Labor After Cesarean

Objective: To develop and validate a multivariable prediction model and clinically actionable risk score for vaginal birth after cesarean (VBAC) succe...

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