Pediatrics

Latest AI and machine learning research in pediatrics for healthcare professionals.

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Long-Term Carotid Plaque Progression and the Role of Intraplaque Hemorrhage: A Deep Learning-Based Analysis of Longitudinal Vessel Wall Imaging

Carotid atherosclerosis is a major contributor in the etiology of ischemic stroke. Although intraplaque hemorrhage (IPH) is known to increase stroke risk and plaque burden, its long-term effects on plaque dynamics remain unclear. This study aimed to evaluate the long-term impact of IPH on carotid plaque burden progression using deep learning-based segmentation on multi-contrast magnetic resonance ...

Statistical Applications in Pediatric Endocrinology: A Simulation on Metformin’s Effect on HbA1c in High-Risk Adolescents

Metformin has been increasingly used off-label in adolescents with type 1 diabetes (T1D) or prediabetic conditions to improve glycemic control. Despite clinical trials suggesting modest improvements in HbA1c, evidence remains mixed and methodologically limited. This paper introduces a simulation framework to evaluate advanced causal inference estimators—including Targeted Maximum Likelihood Estima...

Clinical Validation of AI/ML Based Model for Down Syndrome Detection Through Graphical Analysis of Facial Dysmorphic Features

Down Syndrome is associated with high mortality in India, due to non-diagnosis/ late-diagnosis resource constraints. The objective of the present stud...

Systems Vaccinology Reveals Distinct Immune Signatures of Inhaled and Intramuscular SARS-CoV-2 Vaccination in Humans

Mucosal vaccines may reduce both infection and transmission by engaging local immunity, yet the immunological pathways they activate in humans remain ...

The Brain Imaging and Neurophysiology Database: BINDing multimodal neural data into a large-scale repository

The Brain Imaging and Neurophysiology Database (BIND) represents one of the largest multi-institutional, multimodal, clinical neuroimaging repositorie...

From Concept to Code: AI- Powered CODE-ICH Transforming Acute Neurocritical Response for Hemorrhagic Strokes

Intracerebral hemorrhage (ICH) is among the most devastating forms of stroke, characterized by high early mortality and limited time-sensitive treatme...

Physician Readiness for AI in Primary Care: A Cross-Sectional Survey on the Knowledge-Attitude Gap and Implementation Priorities in Switzerland

Primary care artificial intelligence adoption among United States (US) physicians accelerated from 38% to 66% within one year. Implementation strategi...

Towards Automated Neonatal EEG Analysis: Multi-Center Validation of a Reliable Deep Learning Pipeline

To evaluate the reliability and generalization of NeoNaid, a fully automated software tool for neonatal EEG analysis, based on functional brain age (F...

Leveraging Reddit data for Context-enhanced Synthetic Health Data Generation to Identify Low Self Esteem

Low self-esteem (LoST) is a latent yet critical psychosocial risk factor that predisposes individuals to depressive disorders. Although structured too...

Admission photoplethysmography-based mortality prediction in hospitalized Ugandan children with suspected or confirmed infection: a feasibility study

Sepsis remains a major cause of preventable pediatric hospital deaths in developing countries, with progress hindered by the lack of effective risk id...

PregMedNet: Multifaceted Maternal Medication Impacts on Neonatal Complications

While medication use is common among pregnant women, medication safety remains insufficiently characterized because studies in pregnant women are chal...

Arkangel AI, OpenEvidence, ChatGPT, Medisearch: are they objectively up to medical standards? A real-life assessment of LLMs in healthcare

Large language models (LLMs) are increasingly used in healthcare, but standardized benchmarks fail to capture their validity and safety in real-world ...

Intraoperative Metabolomic-Guided Precision Surgery for Pediatric Brain Tumors: A Systematic Review of Multi-Modal Molecular Imaging Platforms and Artificial Intelligence Integration

Pediatric brain tumors are the leading cause of cancer death in children, with surgical resection critical for survival and neurodevelopment. Intraope...

A Glioma Stem Cell–Associated Transcriptomic Program Predicts Survival Across Adult and Pediatric High-Grade Gliomas

High-grade gliomas (HGGs), including adult glioblastoma (GBM) and pediatric diffuse intrinsic pontine gliomas (DIPGs), are sustained by glioma stem ce...

Hemi-brain growth as a biomarker for whole brain growth

Accurate cerebrospinal fluid (CSF) and brain volume estimation are important components for evaluating hydrocephalus treatments, including shunts and ...

Development and Validation of a parsimonious AI-Based Risk Score for Mortality in Heart Failure: A UK cohort study

Accurate risk stratification in heart failure (HF) is crucial to guide clinical decisions, optimise therapeutic strategies and inform resource allocat...

Open-source solution for evaluation and benchmarking of large language models for public health

Large language models (LLMs) have demonstrated remarkable capabilities in various natural language processing tasks, including text classification, in...

Synthetic Validation of Pediatric Trust Instruments using Persona-Driven Large Language Models

Trust is foundational to patient-physician relationships and is associated with improved care-seeking and adherence in primary care. However, validate...

Artificial Intelligence Predicts Health-Related Quality of Life for Adolescent Idiopathic Scoliosis

Adolescent idiopathic scoliosis (AIS) has a large impact on health-related quality of life (HRQoL) including poor psychosocial functioning, body image...

Topological Entropy and Homology Reveal Interpretable and Real-Time Neural Signatures in Pediatric EEG

Decoding neural states from pediatric EEG in naturalistic settings remains challenging due to signal noise, motion artifacts, and intersubject variabi...

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