Primary Care

Preventive Care

Latest AI and machine learning research in preventive care for healthcare professionals.

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Showing 2641-2660 of 9,129 articles

Automated Deep Learning-Based Detection of Early Atherosclerotic Plaques in Carotid Ultrasound Imaging

Carotid plaque presence is associated with cardiovascular risk, even among asymptomatic individuals. While deep learning has shown promise for carotid plaque phenotyping in patients with advanced atherosclerosis, its application in population-based settings of asymptomatic individuals remains unexplored. We developed a YOLOv8-based model for plaque detection using carotid ultrasound images from 19...

Machine Learning-Driven Identification of Serotype-Independent Pneumococcal Vaccine Candidates using samples from Human Infection Challenge Studies

Identifying conserved, immunogenic proteins that confer protection against Streptococcus pneumoniae colonisation could enable development of serotype-independent vaccines. We analysed baseline samples from 86 healthy adults experimentally challenged with pneumococcal serotypes 6B or 15B to investigate whether immune responses to 75 universally expressed pneumococcal proteins associated with protec...

Development of a Hypertension Risk Prediction Model using Nationally Representative Survey Data: A Machine Learning Approach and Web Application Deployment

Hypertension is a major modifiable risk factor for cardiovascular diseases. Early identification of high-risk individuals using predictive models can ...

Artificial Intelligence in Early Detection of Autism Spectrum Disorder for Preschool ages: A Systematic Literature Review

Early detection of autism spectrum disorder (ASD) improves outcomes, yet clinical assessment is time-intensive. Artificial intelligence (AI) may suppo...

Plasma proteome profiling identifies predictive signatures for preterm birth risk

Preterm birth (PTB) is a major public health concern, and its associated complications account for 16.6% of deaths in children under five years. Over ...

Scalable screening for emergency department missed opportunities for diagnosis using sequential eTriggers and large language models

Missed opportunities for diagnosis (MODs), sometimes termed diagnostic errors, are a major cause of patient morbidity and mortality in the emergency d...

Childhood Maltreatment and Risk for Illicit Substance Use: Evidence for Mid-Adolescence as a Sensitive Exposure Period

Childhood maltreatment is a well-established risk factor for substance misuse. However, it remains unclear whether risk for specific illicit substance...

Body composition and melanoma incidence risk: insights from a longitudinal lung cancer screening cohort

This study explored the association between low-dose computed tomography (LDCT)-derived body composition and melanoma incidence risk. LDCT scans from ...

Advancing Breast Cancer Detection: A Comprehensive Evaluation of Machine Learning Models on Mammogram Imaging

Breast cancer, which is among the top causes of cancer-related deaths in women worldwide, demonstrates the importance of effective and rapid diagnosti...

First-in-Human Study of a First-in-Class AI-Designed Monoclonal Antibody (GB-0669) Against the Conserved SARS-CoV-2 Spike S2 Stem Helix

Antibodies against the SARS-CoV-2 spike receptor-binding domain provided effective COVID-19 treatment until resistant variants emerged. GB-0669 is a h...

TARGET-AI: a foundational approach for the targeted deployment of artificial intelligence electrocardiography in the electronic health record

Artificial intelligence (AI) applied to routine electrocardiograms (ECGs) offers promise for screening of structural heart disease (SHD), yet broad cl...

Systems Vaccinology Reveals Distinct Immune Signatures of Inhaled and Intramuscular SARS-CoV-2 Vaccination in Humans

Mucosal vaccines may reduce both infection and transmission by engaging local immunity, yet the immunological pathways they activate in humans remain ...

Foundation model embeddings enable cardiovascular screening for people living with HIV in Vietnam using wearable signals

Cardiovascular disease (CVD) screening faces significant challenges in resource-limited settings, where infrastructure and computational constraints p...

Prospective Evaluation of AI Risk Stratification for Triaging Expedited Screening Mammogram Interpretation

To prospectively evaluate the feasibility and performance of expedited screening mammogram interpretation for women identified as high-risk by a deep ...

Understanding the Relationship Between Germ Layer Origin and Cancer Therapy Response: A Systematic Review

Cancer therapeutic response patterns may be fundamentally influenced by embryonic germ layer origin. Emerging evidence suggests mesoderm-derived malig...

A machine learning model to support the screening for methods guidance articles in MEDLINE: A performance evaluation of ASReview simulation mode

Advances in clinical research methods are frequently published in biomedical journals, but identifying these articles remains challenging due to their...

Artificial Intelligence-Enabled Electrocardiogram for Elevated Left Ventricular Filling Pressure

Left ventricular filling pressure (LVFP) is associated with heart failure symptoms, a key prognostic marker, and a therapeutic target, but is difficul...

Predicting Amyloid Positivity Through Proteomic and Machine Learning Approaches

Alzheimer’s disease is a progressive neurodegenerative disorder where early detection remains difficult. To address this challenge, we analysed a larg...

Optimized Machine Learning Algorithms for the Classification and Diagnosis of Sleep Disorders

Sleep disorders, including insomnia and obstructive sleep apnea, affect millions of individuals worldwide but are frequently undetected due to the hig...

Clinical Implementation of an AI Algorithm for Substance Misuse Screening in Hospitalized Adults

Manual inpatient screening for substance misuse is labor-intensive and inconsistently applied. Evaluation of artificial intelligence (AI)–assisted scr...

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