Primary Care

Preventive Care

Latest AI and machine learning research in preventive care for healthcare professionals.

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Microscale Multiplexed Antigen-Specific Antibody Fc Profiling for Point-of-Care Diagnosis of Tuberculosis

Accurate, affordable tuberculosis (TB) diagnostics that do not require sputum samples are urgently needed for TB control and elimination. Prior serological TB tests have failed due to low accuracy in diagnosing active TB (ATB) in endemic areas where baseline seropositivity, due to latent infection (LTBI) or vaccination, is common. We combined high-throughput sample-sparing antibody-omics with mach...

The impact of a SmartPhone applicatiOn for skin cancer risk assessmenT on the healthcare system (SPOT-study): A randomized controlled trial

Artificial intelligence (AI)-based mobile health (mHealth) smartphone apps for skin cancer detection are increasingly available to the general population, but their impact on care is unclear. The SPOT study is an investigator-initiated and -designed, unblinded, randomized controlled trial. Participants from a Dutch non-profit health insurance living in and around region Rotterdam the Netherlands, ...

Dual-Model LLM Ensemble via Web Chat Interfaces Reaches Near-Perfect Sensitivity for Systematic-Review Screening: A Multi-Domain Validation with Equivalence to API Access

Prior work showed that state-of-the-art (mid-2025) large language models (LLMs) prompted with varying batch sizes can perform well on systematic revie...

Sociodemographic Bias in Large Language Model Clinical Trial Screening

Large language models (LLMs) are increasingly used in randomized clinical trial (RCT) screening, but their potential for sociodemographic bias remains...

A three-dose MVA-BN mpox vaccination series improves the quality of anti-monkeypox virus immunity

The 2022 global outbreak of clade IIb mpox represented a turning point in public health’s handling of poxviruses. The primary vaccine available for pr...

LLM-based Multi-Agent Collaboration for Abstract Screening towards Automated Systematic Reviews

Systematic reviews (SRs) are essential for evidence-based practice but remain labor-intensive, especially during abstract screening. This study evalua...

Artificial Intelligence Significantly Improves Adenoma Detection Rate but Does Not Affect Polyp Detection Rate in Colonoscopy: A Propensity Score Matching Study

Colorectal cancer (CRC) remains a major cause of cancer-related morbidity and mortality worldwide. Endoscopy and adenoma removal are effective in redu...

Evaluating Large Language Models for Colonoscopy Preparation Assistance: Correctness and Diversity in Synthetic Dialogues

Colorectal cancer is the third leading cause of cancer-related deaths in the United States, and colonoscopy remains the gold standard for early detect...

An Artificial Intelligence Model for Detection of Heart Failure with Preserved Ejection Fraction: A Report from HeartShare Study

Heart failure with preserved ejection fraction (HFpEF) accounts for over half of all heart failure cases in the United States and remains a diagnostic...

Acoustic Analysis of Primary Care Patient-provider Conversations to Screen for Cognitive Impairment

Cognitive impairment (CI) is often under detected in primary care due to time and resource constraints. Passive analysis of clinical dialogue may offe...

Machine learning-optimized perinatal depression screening: Maximum impact, minimal burden

Perinatal depression affects up to 30% of pregnant and postpartum women, which has increased since the COVID-19 pandemic, making rapidly identifying a...

Explainable Machine Learning for Early Detection of Mild Cognitive Impairment, Fall Risk, and Frailty Using Sensor-Based Motor Function Data

This study aimed to design and evaluate an explainable machine learning (ML) framework that integrates sensor-based motor assessments with demographic...

Opportunistically Detecting Signs of Hypertension on a Consumer Smartwatch

Hypertension is a silent killer, with over half of affected adults unaware of their condition1,2. This lack of awareness is a major concern, as early ...

Early Detection of Cardiovascular Disease Risk Using Multi-Parameter Biomarker Analysis and Machine Learning: A Prospective Cohort Study

Cardiovascular disease (CVD) remains the leading cause of mortality globally, with many events occurring in individuals without prior diagnosed condit...

Detecting Mental Disorders in Social Media Using a Transformer-Based Ensemble of Binary Classifiers

This study introduces a novel transformer-based ensemble framework for the multi-label detection of mental health disorders from social media posts. U...

Estrogen upregulates NF-κB and TNF signaling in B cells to cause sex and age differences in antibody responses to seasonal influenza vaccination

Sex differences in the humoral immune responses to the seasonal quadrivalent influenza vaccine (QIV) in young adults (YA; 18-49yo) or high dose QIV in...

Implementation of an Opioid Use Disorder (OUD) Machine-Learning Phenotype in Real-Time for the ADAPT Project

Develop and deploy a real-time, EHR-integrated machine learning phenotype to identify emergency department (ED) patients with opioid use disorder (OUD...

Sensitive and Specific Early-Stage Breast Cancer Detection using Deep Proteome Profiling from Plasma

Proteome-guided liquid biopsy tests hold immense promise for the future of early cancer detection. Our previous published work has shown strong perfor...

A novel open access multimodal dataset of nodule imaging and circulating proteome from a lung cancer screening cohort

Low-dose computed tomography (LDCT) lung cancer screening has significantly enhanced early detection and patient survival rates in the population at r...

TWINVAX: conceptual model of a digital twin for immunisation services in primary health care.

INTRODUCTION: This paper presents a proposal for the modelling and reference architecture of a digital twin for immunisation services in primary healt...

Jan 1 2025 40438062
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