Preventive Care

Multidimensional proteomics and explainable AI feature selection identify cross-platform lung cancer molecular signature in blood plasma.

BACKGROUND: Lung cancer is the leading cause of cancer mortality worldwide despite the availability of low-dose computed tomography (LDCT) for screening in high-risk populations. METHODS: To develop an approach and identify blood-based protein signatures for lung cancer that can be deployed across platforms, we combined data-independent acquisition mass-spectrometry (DIA-MS) and proximity extensio...

Development, internal testing, and external validation of an interpretable machine-learning model for predicting imaging-confirmed in-hospital postoperative deep vein thrombosis in older patients with patellar fractures.

BACKGROUND: Older patients with patellar fractures may be at increased risk of postoperative deep vein thrombosis (DVT) because of trauma, perioperative immobilization, and age-related prothrombotic susceptibility. However, risk-stratification tools tailored to this specific population remain limited. We aimed to develop, internally test, and externally validate an interpretable machine-learning m...

Non-invasive periodontal screening using self-reported-oral-health (SROH) questionnaire and salivary biomarkers: development and validation of machine learning models.

BACKGROUND: Accurate and accessible screening tools for periodontitis are essential for early detection and disease prevention. This study evaluated a...

An explainable machine learning method for identifying key atherogenic lipid biomarkers in abdominal obesity among the Southern Chinese population.

BACKGROUND: Abdominal obesity (AO) significantly contributes to cardiometabolic diseases and poses an increasing public health challenge. Composite li...

Understanding resistance in glioblastoma: insights into personalized and targeted therapeutic strategies.

Glioblastoma multiforme (GBM) is the most common and aggressive primary malignant brain tumor. Despite combined treatments, including surgical removal...

Machine learning, bioinformatics analysis and chemical screening streamline target validation by identifying RNA helicase as a druggable essential protein in tobacco mosaic virus.

INTRODUCTION: Plant viruses inflict annual economic losses exceeding $30 billion and pose a significant threat to global food security. Discovering re...

Smartphone-Based Proactive Self-Screening for Ocular Surface Malignancies: A Nonrandomized Clinical Trial.

IMPORTANCE: Ocular surface malignancies pose risks to vision and survival yet are frequently misdiagnosed as benign lesions because of their subtle pr...

Early Immunological Biomarkers for Personalized Treatment Selection in Severe COVID-19: Post Hoc Machine Learning Analysis of a Randomized Clinical Trial.

BACKGROUND: Severe COVID-19 is a global health concern despite continuous vaccination campaigns because current therapies, such as dexamethasone and r...

[State of the art and innovations in breast cancer prevention and screening strategies].

Breast cancer is the most common cancer among women, and its incidence is increasing, particularly in France, due to changes in lifestyle and exposure...

Development, validation, and user-centric evaluation of an interpretable machine learning decision support tool for the preoperative prediction of mild bleeding disorders (MBD-Check): a prospective diagnostic prediction study.

BACKGROUND: Mild bleeding disorders are the most common inherited bleeding disorders, often leading to perioperative haemorrhages. Preoperative screen...

Label-free interferometry platform for drug response profiling of bioprinted tumor organoids at single-organoid resolution.

Organoids have become mainstay tools for drug discovery and personalized medicine. High-throughput imaging readouts for drug screening of tumor organo...

PepPharmaHub: a cloud-based platform integrating multimodel language architectures with curated data resources for therapeutic peptide discovery.

BACKGROUND: Therapeutic peptides represent a rapidly expanding class of drug candidates due to their diverse biological activities and high specificit...

Development and Interpretability Analysis of a Stacking Ensemble Model for Early Prediction of Nutritional Risk in Intensive Care Unit Patients: Retrospective Cohort Study.

BACKGROUND: Malnutrition in critically ill patients is associated with increased morbidity and mortality, yet traditional screening tools such as the ...

The Influence of Social Media Messaging on Human Papillomavirus Vaccine Attitudes and Confidence Among Adolescent Males: Group Discussion Study.

BACKGROUND: Despite the human papillomavirus (HPV) vaccine being available to males for the past 12 years, adolescent males continue to lag in HPV vac...

Learning and deskilling effects of artificial intelligence in colonoscopy among endoscopists with different levels of experience: a pragmatic, prospective trial.

BACKGROUND: The effect of computer-aided detection (CADe) on performance of endoscopists with different experience levels is not well understood. This...

Advances in the diagnosis and detection of chronic kidney disease.

Chronic kidney disease affects 788-844 million adults worldwide and is projected to become the fifth leading cause of death by 2040. Global burden est...

Pan-pathogen vaccine approaches: Toward broad-spectrum immunity in a One Health era.

Emerging and re-emerging infectious diseases (EIDs) represent an escalating threat to global public health, as exemplified by outbreaks of COVID-19, E...

Evaluating machine learning tools to assist title and abstract screening in systematic literature reviews: a report based on the EULAR RA Management Recommendations Task Force.

OBJECTIVES: Systematic literature reviews (SLRs) provide the scientific basis for European Alliance of Associations for Rheumatology (EULAR) task forc...

Predicting knowledge of cervical cancer screening among reproductive-age women in sub-saharan africa using machine learning algorithms.

Sub-Saharan Africa faces twice the incidence and up to fifteen times the fatality rate of cervical cancer compared to developed countries. Screening c...

Proteomic signatures of early retinal neurodegeneration in type 2 diabetes mellitus.

BACKGROUND: Retinal neurodegeneration is an early and independent feature of diabetic retinal disease and has been proposed as a window into the syste...