Primary Care

Latest AI and machine learning research in primary care for healthcare professionals.

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Explainable reinforcement learning for glucose monitoring based on shapley value analysis.

BACKGROUND AND OBJECTIVE: Effective diabetes management requires continuous regulation of blood glucose in response to complex factors such as diet, activity, stress, and medication. Advances in continuous glucose monitoring and machine learning have improved short-term glucose prediction. However, preprocessing of signals like insulin, carbohydrate intake, heart rate, and activity to better captu...

Jan 29 2026 41619710

Anti-Inflammatory Properties of Dendrobium: A Systematic Review of Pharmacological Mechanisms.

ETHNOPHARMACOLOGICAL RELEVANCE: In Traditional Chinese Medicine (TCM), Dendrobium species have long been utilized to alleviate various inflammatory symptoms, particularly those characterized by Yin deficiency with internal heat and stomach deficiency-heat, including impaired fluid production, dysregulated stomach Qi, and poor appetite. The inflammatory response is regulated by multiple signaling p...

Jan 29 2026 41619861
Exhaled breath analysis to stratify cardiovascular risk using machine learning model: a novel frontier in preventive cardiology.

Despite major progress in diagnosis and treatment, cardiovascular disease (CVD) continues to be the leading cause of death worldwide, responsible for ...

Jan 29 2026 41494207
First-Trimester Machine Learning to Predict Preeclampsia in Normotensive Pregnancies by American Heart Association Guidelines.

This study aimed to determine whether unsupervised machine learning can identify phenotypically distinct subgroups at increased risk for preeclampsia ...

Jan 29 2026 41525794
Fabricating a SMVF@GO@Ag Composite Aerogel SERS Sensor for the Enrichment and Label-Free Detection of Urinary VOCs.

The detection of volatile organic compounds (VOCs) in urine is a noninvasive diagnostic technique with tremendous promise, holding great potential for...

Jan 29 2026 41609313
Automated deep learning for detection and measurement of adrenal masses in contrast-enhanced abdominal CT.

OBJECTIVES: Adrenal tumors can be functional or malignant, yet they are often overlooked in abdominal CT. This study aimed to develop and validate a f...

Jan 29 2026 41609765
Patient Perspectives on AI-Powered Medical Robots in Breast and Prostate Cancer Care: Qualitative Study.

BACKGROUND: Nearly 250,000 cancer cases are diagnosed annually in Canada, with breast and prostate cancer representing 25% and 22% of new cases, respe...

Jan 29 2026 41610271
Characterization of Models for Identifying Physical and Cognitive Frailty in Older Adults With Diabetes: Systematic Review and Meta-Analysis.

BACKGROUND: Physical frailty and cognitive frailty are increasingly recognized as critical geriatric syndromes among older adults with diabetes, contr...

Jan 29 2026 41610414
A systematic review of the scope and impact of rural primary healthcare innovations using digital health technology.

OBJECTIVES: Digital technology in primary healthcare service delivery can enhance accessibility, service delivery and health outcomes in rural populat...

Jan 29 2026 41611458
Deep neural network-based biostatistical analysis for disease marker screening.

Traditional statistical methods have limitations when dealing with high-dimensional, small-sample data. Deep learning methods have attracted widesprea...

Jan 29 2026 41611762
A tri-omics and machine learning framework identifies prognostic biomarkers and metabolic signatures in sepsis.

Sepsis is a complex systemic inflammatory syndrome that currently lacks stable and specific biomarkers. Multi-omics integration combined with machine ...

Jan 29 2026 41611834
Optimizing Early Detection of Diabetic Kidney Disease through Synergistic Biomarkers and Serum Metabolites in Human.

BACKGROUND: Diabetic kidney disease (DKD) progresses to end-stage renal disease more rapidly than chronic kidney disease due to persistent hyperglycem...

Jan 29 2026 41605139
PIDgeon: An Explainable AI Model for Improved Flow Cytometry-Based Screening of Lymphoid Primary Immunodeficiencies.

BACKGROUND: Primary immunodeficiencies (PIDs) are rare disorders caused by immune system defects that are commonly screened using multi-parameter flow...

Jan 29 2026 41605242
[Expert consensus on the application of artificial intelligence in stomatology].

In recent years, artificial intelligence (AI) has rapidly advanced in the field of oral medicine, with applications extending across disease screening...

Jan 29 2026 41605470
Development and Validation of a Machine Learning Model for Dementia Staging in a Heterogeneous Cognitive Impairment Cohort Using Multimodal Features.

RATIONALE AND OBJECTIVES: With the emergence of disease-modifying therapies, precise staging of dementia is urgent. This study aimed to develop a mach...

Jan 28 2026 41611541
Automated neural network femur segmentation performance in computed tomography images of older adults with obesity.

Femur segmentation is a precursor to image analysis pipelines that evaluate hip bone measures with subject-specific finite element models, but histori...

Jan 28 2026 41704480
Engineering class I terpene synthases for skeletal diversity: strategies and applications.

Covering: up to August 2025Terpenoids constitute nature's largest and most structurally diverse class of natural products, with extensive applications...

Jan 28 2026 41369946
Digital hypertension in 2024-2025: emerging evidence and future directions.

Recent advances in digital technology are remarkable, and they are driving profound transformations in healthcare and medical research. Within this co...

Jan 28 2026 41593333
The Development and Use of AI Chatbots for Health Behavior Change: Scoping Review.

BACKGROUND: Artificial intelligence (AI) chatbots are technologies that facilitate human-computer interaction through communication in a natural langu...

Jan 28 2026 41604667
Ethical Knowledge, Challenges, and Institutional Strategies Among Medical AI Developers and Researchers: Focus Group Study.

BACKGROUND: As artificial intelligence (AI) becomes increasingly embedded in clinical decision-making and preventive care, it is urgent to address eth...

Jan 28 2026 41604668
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