Latest AI and machine learning research in primary care for healthcare professionals.
BACKGROUND: The genesis of Parkinson's disease (PD), a common central neurodegenerative disorder, involves dysregulation of protein posttranslational modifications (PTM). The primary objective of this study was to screen key PTM-associated genes (PTMGs) serving as diagnostic indicators and potential therapeutic targets in PD. METHODS: Peripheral blood transcriptomic data for PD cohorts and healthy...
Retinitis pigmentosa (RP) is a group of inherited retinal diseases that are caused by genetic defects that lead to progressive photoreceptor loss and eventual blindness. Early diagnosis would be helpful for effective management of the disease; however, many patients stay unaware of early symptoms. Meanwhile, fundus images are widely obtained during routine medical checkups but are underused for de...
Artificial intelligence (AI), particularly foundation and generative models, is reshaping the practice of hepatology through enhanced knowledge synthe...
Organ- and organoid-on-a-chip technologies provide critical human-relevant models for drug screening. Despite their promise, translating their complex...
INTRODUCTION: The composition of intestinal flora affects the occurrence and development of type 2 diabetes to some extent, with dysregulation of the ...
BACKGROUND: Stroke is a major complication of atrial fibrillation (AF), and risk prediction using the congestive heart failure, hypertension, age, dia...
Motor complications become increasingly prominent as Parkinson's disease (PD) progresses. Although device-aided therapies (DAT) improve symptoms contr...
Zebrafish are an effective animal model widely utilized in biomedical research. They are known for their rapid reproduction and substantial genetic si...
Peptide-activated G protein-coupled receptors (GPCRs) regulate physiological processes through interaction with neuropeptides and peptide hormones. Id...
BACKGROUND: In cardiovascular magnetic resonance (CMR), myocardial native T1 mapping enables quantitative, non-invasive tissue characterization and is...
OBJECTIVES: Early diagnosis of Parkinson's disease (PD) is complicated. Speech impairment, as an early symptom of PD, offers a noninvasive, scalable b...
Health communication often faces a segmentation-intervention gap: psychographic segmentation identifies meaningful audience profiles, but these profil...
Current diagnostic methods for Gestational Diabetes Mellitus (GDM) inadequately reflect early placental pathophysiology. Accelerated cellular senescen...
Earlier identification, regulation of impurities in pharmaceutical products is critical throughout the medication development process because they hav...
Benefits from continuous glucose monitors (CGMs) may depend on how devices are used over time-not only how often they are used. We linked one year of ...
Drug-drug interactions (DDIs) are a critical safety issue in clinical practice, as they can lead to severe and often unpredictable adverse effects. Th...
This paper examines the integration of artificial intelligence (AI) into cancer screening programmes, focusing on the associated equity challenges and...
Hypertension is a hallmark of vascular aging; however, the epigenetic link between biological aging and blood pressure remains unclear. This epigenome...
BACKGROUND: CT angiography (CTA) is a key investigation in cerebrovascular disease. However, CTA is not always available and it also requires intraven...
Many research questions-particularly those in environmental health-do not involve binary exposures. In environmental epidemiology, this includes multi...