Primary Care

Latest AI and machine learning research in primary care for healthcare professionals.

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Clinical and Metabolomic Panel for Noninvasive Screening of Biopsy-Confirmed MASH in Children and Adolescents.

BACKGROUND & AIMS: Noninvasive tests to identify pediatric metabolic dysfunction-associated steatohepatitis (MASH) remain a critical need. We aimed to develop and validate a screening panel that identifies biopsy-confirmed MASH in children and adolescents using clinical and metabolomics data. METHODS: Fasting serum from youth in NASH CRN studies and healthy participants underwent untargeted metabo...

Aug 30 2026 42669329

Technology and Obesity: A Year in Review.

SMART technological advancements help diagnose, treat, and monitor various diseases at the earliest stages. It presents an opportunity to maintain the key components of conventional obesity management programming while reducing costs and provider time inputs. Various machine learning models have helped predict the risks of obesity and metabolic syndrome. Additionally trained convolutional neural n...

Aug 29 2026 42667572
Non-Oncology Biomarkers in Precision Medicine: A Narrative Review.

Precision medicine has revolutionized oncology by leveraging biomarkers for individualized therapy selection, early diagnosis, and real-time disease m...

Aug 29 2026 42667586
Pooled two-cohort MRI body composition phenotyping with open-source deep learning.

BACKGROUND: Body mass index fails to capture variation in fat and muscle distribution that determines metabolic health and disease risk. MRI enables r...

Aug 29 2026 42668286
Automated artificial intelligence performance for longitudinal pulmonary nodule matching in lung cancer screening.

Accurate longitudinal nodule matching is a critical technical prerequisite for automated growth rate (volume doubling time) assessment in lung cancer ...

Aug 29 2026 42668303
Myocardial Fibrosis in Pediatric Heart Disease: Mechanisms, Imaging Biomarkers, Clinical Consequences, and Emerging Antifibrotic Therapies.

Myocardial fibrosis is increasingly recognized as a central determinant of adverse cardiac remodeling and long-term cardiovascular outcomes in childre...

Aug 28 2026 42661244
Personalized evaluation of NT-proBNP and clinical characteristics in suspected heart failure: the PRECISE-HF study.

BACKGROUND AND AIMS: N-terminal pro-B-type natriuretic peptide (NT-proBNP) is recommended to guide echocardiography referral in community-based patien...

Aug 28 2026 42663089
The Forcing Factors That Predict Obesity: A Cross-Sectional Multilevel Machine Learning Model of US County-Level Prevalence.

OBJECTIVE: Variables predicting obesity are not limited to individual-level risk factors. The purpose of this study is to assess multilevel predictors...

Aug 28 2026 42663397
Electrocardiogram-Based Deep Learning to Prioritize Testing for Transthyretin Amyloid Cardiomyopathy.

IMPORTANCE: Transthyretin amyloid cardiomyopathy (ATTR-CM) is a treatable cause of heart failure, but diagnosis is often delayed. Accessible tools to ...

Aug 28 2026 42663420
Microphysiological immune-on-chip systems: engineering human immunity for precision immunotherapy, vaccine development, and autoimmune disease modelling.

Microphysiological immune-on-chip systems have emerged as transformative biomedical microdevices capable of recreating the structural, biochemical, an...

Aug 28 2026 42663717
Structural Heart Interventions in Women with Congenital Heart Disease.

PURPOSE OF REVIEW: To provide a review of current transcatheter interventions in women with congenital heart disease, with a focus on sex-specific con...

Aug 28 2026 42663756
Evolving an Aptameric Nose for Synthetic Cannabinoids Through Modular Reprogramming of Specificity.

Discerning subtle structural differences among highly similar small molecules remains a major challenge for synthetic receptors. Natural olfactory sys...

Aug 28 2026 42664060
Dockformer: A Transformer-Based Molecular Docking Paradigm for Large-Scale Virtual Screening.

Molecular docking is a critical step in drug development, enabling the virtual screening of compound libraries to identify potential ligands for speci...

Aug 28 2026 42664088
Risks of Major Adverse Kidney Events in Non-Hispanic Black Patients with Diabetes or Hypertension: A real-world cohort study.

INTRODUCTION: Chronic kidney disease (CKD) disproportionately burdens non-Hispanic Black (NHB) patients who experience a three- to four-fold higher ri...

Aug 28 2026 42664178
Leveraging artificial intelligence in the early detection of ovarian cancer: Development and validation of a risk prediction model.

OBJECTIVE: To develop and validate a predictive tool to estimate the risk of ovarian cancer in a screening setting. METHODS: Machine learning was leve...

Aug 28 2026 42664614
Daily 1 km satellite-based PM2.5 exposure estimates in Bangladesh, 2020-2025: spatiotemporal patterns and implications for environmental health.

Bangladesh experiences some of the highest ambient PM2.5 concentrations globally and remains one of the most monitoring-sparse high-burden regions. To...

Aug 28 2026 42665078
Community-based paediatric eye care in low- and middle-income countries: bridging the gap between policy and practice.

Childhood visual impairment and blindness remain major public health concerns in low- and middle-income countries (LMICs), despite a substantial propo...

Aug 28 2026 42665334
Performance and label efficiency of traditional deep-learning models and a retina-specific foundation model for ocular and systemic disease detection: a retrospective comparative study.

BACKGROUND: RETFound, a self-supervised retina-specific foundation model, has shown potential in downstream tasks, but its performance in comparison w...

Aug 28 2026 42665469
Machine learning-based prediction model for predicting the impact of insulin resistance on the risk of ischemic cardiomyopathy.

BACKGROUND: The triglyceride-to-high-density lipoprotein cholesterol (TG/HDL-C) ratio and triglyceride glucose-body mass (TyG-BMI) index are reliable ...

Aug 28 2026 42665815
Artificial intelligence-driven study selection in systematic reviews of randomized controlled trials, emulated trials and economic evaluation studies using large language models.

Systematic reviews (SRs) are key to evidence-based medicine but are often labor-intensive, especially in the study selection step. This study assessed...

Aug 28 2026 42664251
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