Primary Care

Latest AI and machine learning research in primary care for healthcare professionals.

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Mapping ovarian cellular and molecular landscape across the lifespan of women: a scoping review.

BACKGROUND: With growing interest in ART, fertility preservation, and postmenopausal health of women, reproductive medicine is increasingly focused on characterizing oocytes and ovarian tissue composition, as well as understanding the molecular mechanisms that guide ovarian function throughout its lifecycle. High-throughput omics technologies have enabled the characterization of different molecula...

Jul 17 2026 42467724

Development and external validation of AI-ECG models in athlete pre-participation screening: Performance, limitations, and clinical implications.

BACKGROUND: Pre-participation screening (PPS) in competitive athletes aims to identify cardiovascular diseases associated with sudden cardiac death (SCD). Although the 12‑lead electrocardiogram (ECG) represents the cornerstone of PPS, structural abnormalities may demonstrate limited or incomplete electrical expression, particularly in asymptomatic athletes with physiological remodeling. Artificial...

Jul 17 2026 42468692
Current Perspectives on Thyroid Nodule Evaluation: Integrating Cytomorphology, Ultrasound Risk Stratification, and Molecular Testing.

Fine-needle aspiration biopsy (FNAB) remains the cornerstone of preoperative evaluation of thyroid nodules and represents one of the most enduring and...

Jul 17 2026 42468828
Interpretable diabetes risk prediction: a comparative study of tree-based algorithms using SHAP and LIME.

The global burden of diabetes mellitus continues to increase, particularly in low- and middle-income countries. Prior studies have explored the use of...

Jul 17 2026 42469313
Clinical applications of artificial intelligence in hypertension management: current evidence and future perspectives.

BACKGROUND: Hypertension remains the leading modifiable risk factor for cardiovascular morbidity and mortality worldwide, with persistently inadequate...

Jul 17 2026 42469487
Human salivary microbiome as a potential non-invasive biomarker for early-onset colorectal cancer screening: a prospective study.

BACKGROUND: The incidence of early-onset colorectal cancer (EOCRC) has been increasing in recent years, the carcinogenesis of which has been linked to...

Jul 17 2026 42469627
Techniques, Performance, and Feasibility of Natural Language Processing for Abstract Screening in Evidence Synthesis: A Systematic Review.

BACKGROUND: Natural language processing (NLP) techniques offer promising solutions for semi-automating the time-consuming process of abstract screenin...

Jul 16 2026 42491247
Strategies to overcome barriers in access to cancer treatment in Latin America: a regional perspective.

Access to high-quality cancer care remains a major challenge across Latin America, particularly for patients with gastrointestinal (GI) malignancies. ...

Jul 16 2026 42583089
Anticipating the Impact of AI on Diet and Exercise Apps: Foresight Study Applying the Futures Wheel.

AI has entered the wellness space through apps and wearables. These technologies can collect real-time data, infer lifestyle patterns, and dynamically...

Jul 16 2026 42462176
A Guideline-Concordant Chatbot Framework for Structured Colorectal Cancer Screening: Multistage Feasibility Study.

BACKGROUND: Colorectal cancer (CRC) screening relies on structured risk assessment and guideline-concordant communication, which remain challenging to...

Jul 16 2026 42464799
Natural language processing identifies symptoms predicting complete coronary artery occlusion in patients with NSTEMI.

AIMS: One in 10 patients present to the emergency department (ED) with symptoms of acute coronary syndrome (ACS). The 13-item ACS Symptom Checklist is...

Jul 16 2026 41645741
Applying artificial intelligence to automate clinical data extraction from veterinary electronic health records: A practical guidance and comparative scoping review.

Veterinary electronic health records are often stored as unstructured free text, and structuring this information into analyzable formats is essential...

Jul 16 2026 42460772
Development and internal validation of an interpretable machine learning model using routine laboratory data for systemic sclerosis-associated pulmonary arterial hypertension.

This study aimed to develop and validate an interpretable machine learning (ML) model using routine laboratory data to support clinical decision-makin...

Jul 16 2026 42461382
Wiz regulates clustered protocadherin genes by restricting CTCF/cohesin loop extrusion in a genomic-distance biased manner.

Zinc finger proteins (ZFPs or ZNFs) constitute the largest family of transcription factors in mammals; however, their regulatory mechanism remains lar...

Jul 16 2026 42461945
Machine Learning Analysis of Sex Differences in Cardiovascular-Kidney-Metabolic Risk Factors and Prognosis Among Patients With Moderate-to-Severe Coronary Artery Calcification: Prospective Cohort Study.

BACKGROUND: Patients with coronary artery calcification exhibit notable sex differences in clinical presentation, particularly concerning the role of ...

Jul 16 2026 42462211
AI for Causality Assessment in Pharmacovigilance: Protocol for a Scoping Review.

BACKGROUND: Pharmacovigilance aims to protect patient safety by identifying and managing adverse events associated with pharmaceuticals. Determining t...

Jul 16 2026 42462221
The Triglyceride Glucose-a Body Shape Index: A Novel Composite Index for Prediction of Periodontitis Risk.

INTRODUCTION AND AIM: Insulin resistance and obesity are significant metabolic risk factors for periodontitis. This study aimed to systematically inve...

Jul 16 2026 42462349
Personalised approach to hypertension treatment: protocol for the HYPERMARKER randomised controlled trial.

INTRODUCTION: Blood pressure treatment response is variable in individual patients, and the choice of medical therapy is often dependent on clinician ...

Jul 16 2026 42463190
Machine learning evaluation of clinical, social and behavioural factors influencing progression from pre-diabetes to type 2 diabetes: a retrospective cohort study in southeast Michigan.

OBJECTIVE: We aimed to use machine learning (ML) models to investigate the impact of clinical, social and behavioural factors on 1-year progression fr...

Jul 16 2026 42463206
Multi-component exercise intervention methods for intelligent assisted diagnosis of sarcopenia in the elderly based on deep learning.

Population aging has made sarcopenia a major public health challenge in geriatric medicine. Current clinical diagnosis relies on large specialized equ...

Jul 16 2026 42463737
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