Primary Care

Latest AI and machine learning research in primary care for healthcare professionals.

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Comparative Machine Learning Analysis of Saliva and Plaque Microbiomes in Children with Type 1 Diabetes

Type 1 diabetes (T1D) is associated with microbial dysbiosis. While most research has focused on the...

Beyond Microbial Abundance: Metadata Integration Enhances Disease Prediction in Human Microbiome Studies

Multiple studies have highlighted the human microbiome’s potential as a biomarker for diagnosing dis...

DLRNA-BERTa: A transformer approach for RNA-drug binding affinity prediction

RNA-based therapies are a rapidly expanding field, offering treatments for a wide range of diseases,...

Single-cell proteomics of pancreatic islet cells reveals type 1 diabetes and donor-specific features

Type 1 diabetes mellitus (T1DM) is the most common severe chronic disease in children and adolescent...

Accelerating Drug Discovery with HyperLab: An Easy-to-Use AI-Driven Platform

HyperLab, developed by HITS, is a web-based, AI-driven drug discovery platform designed to increase ...

Supervised machine learning identifies impaired mitochondrial quality control in β cells with development of type 2 diabetes

In type 2 diabetes (T2D), molecular pathways driving β cell failure are difficult to resolve with st...

MAP-PRS: Multi-Ancestry Portfolio-Based Polygenic Risk Scores

Polygenic Risk Scores (PRS) are emerging tools for predicting an individual’s genetic risk for compl...

Cross-Species Morphology Learning Enables Nucleic Acid-Independent Detection of Live Mutant Blood Cells

In hematology/oncology clinics, molecular diagnostics based on nucleic acid sequencing or hybridizat...

Screening of Oyster Peptides for Anti-Muscle Atrophy Based on Machine Learning and Computer Simulation: Guided by Antioxidant Pathways

Muscle atrophy poses a serious threat to human health, with its primary pathogenic mechanisms closel...

The Liver is an Inflammatory Mediator of Pulmonary Arterial Hypertension

Inflammation is central to pulmonary arterial hypertension (PAH) pathogenesis. The liver regulates s...

Histology-guided 3D virtual staining of microCT-imaged lung tissue via deep learning

Histologically stained tissue sections are considered the gold standard for studying microscopic ana...

SLOGEN: A Structure-based Lead Optimization Model Unifying Fragment Generation and Screening

Lead optimization plays an important role in preclinical drug discovery. While deep learning has acc...

Integrating Genomics into Multimodal EHR Foundation Models

This paper introduces an innovative Electronic Health Record (EHR) foundation model that integrates ...

Ultrahigh throughput screening to train generative protein models for engineering specificity into unspecific peroxygenases

Enzyme engineering is central to developing biocatalysts with improved activity and specificity, yet...

A generalizable cross-continent prediction of esophageal squamous cell carcinoma using the oral microbiome

Esophageal squamous cell carcinoma (ESCC) is a disease with limited tools for early screening and a ...

HyperBind2: Multi-Shot Learning Enables Progressive Improvement in Computational Antibody Discovery

Antibody discovery remains constrained by resource-intensive experimental screening approaches that ...

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