Primary Care

Latest AI and machine learning research in primary care for healthcare professionals.

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AI-driven diagnostic algorithm enhances early detection of paroxysmal nocturnal hemoglobinuria in real-world settings.

Paroxysmal nocturnal haemoglobinuria (PNH) is a rare, life-threatening hematologic disease with diagnostic delays exceeding 5 years in 24% of cases. We developed and deployed an artificial intelligence algorithm analyzing structured and unstructured electronic health record data across 14 healthcare organizations in Poland. Screening of 1,307,140 patients identified 356 high-risk individuals; of 1...

Jul 9 2026 42426209

Construction and validation of an interpretable machine learning model for predicting diabetes risk in COPD patients.

To construct and validate a machine learning (ML) model for predicting diabetes risk in COPD patients, enabling early and personalized intervention. Using data from the MIMIC-IV database, 49 variables were screened by LASSO and logistic regression. Six ML algorithms were constructed and internally validated on a 70%/30% split dataset. Model performance was assessed using multiple metrics, followed...

Jul 9 2026 42426311
MERWACS: Development and external validation of a non-invasive machine learning tool for identifying subjects to be screened for CKD.

Early detection of chronic kidney disease (CKD) is a critical public health priority. However, a gap exists for non-invasive tools to guide screening ...

Jul 9 2026 42424235
Machine learning for predicting emergency department visits in patients with type 2 diabetes: A real-world, multi-institutional study.

BACKGROUND: Patients with type 2 diabetes mellitus (T2DM) prone to acute diabetic complications are at high risk for emergency department (ED) visits,...

Jul 9 2026 42424276
Enhancing the Effectiveness of Attention-Deficit/Hyperactivity Disorder Screening Using the SNAP-IV: A Deep Learning Approach.

Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental condition requiring early and accurate identification to optimize outco...

Jul 8 2026 42421187
Social Determinants of Health and Fentanyl Overdose Mortality Across US Counties: An XGBoost and SHAP Analysis Identifying Silent Risk Counties and Treatment Deserts.

BACKGROUND: Fentanyl overdose deaths are still increasing across the U.S. Even though the crisis is growing, we still do not fully understand which co...

Jul 8 2026 42421361
Systematic review of risk prediction models for autogenous arteriovenous fistula dysfunction in maintenance hemodialysis patients.

OBJECTIVE: To systematically evaluate existing risk prediction models for autogenous arteriovenous fistula (AVF) dysfunction in maintenance hemodialys...

Jul 8 2026 42415707
Global Geospatial Trends in Breast Cancer and Atrial Fibrillation/Flutter Among Older Women: Uncovering Shared Epidemiological Patterns and Etiological Links.

BACKGROUND: Breast cancer (BC) and atrial fibrillation (AF) represent increasing global health burdens with shared risk factors. However, their coinci...

Jul 8 2026 42417071
Precision or Paradox? AI-Driven Adiposity Imaging in Women With Overweight and Obesity: A Systematic Review and Meta-Analysis.

Artificial intelligence (AI) enables automated, high-throughput adiposity quantification, offering refined risk stratification for women with overweig...

Jul 8 2026 42417187
Virus infections and cancers: from mechanisms to therapeutics.

Viral infections are a major contributor to global cancer incidence and mortality. However, integrative reviews that connect viral classification, car...

Jul 8 2026 42417944
Neuropsychological and metabolic interconnectivity in obesity, anorexia and bulimia nervosa - an integrative literature review.

A dysfunctional bi-directional signalling of plural neural networks expresses distinct metabolic disruption with mental health consequences in obesity...

Jul 8 2026 42418024
Risk prediction of non-small cell lung cancer in patients with pulmonary nodules: a single-center cohort study based on six machine learning algorithms.

OBJECTIVE: Lung cancer is a major global public health concern. Non-small cell lung cancer (NSCLC), the most common subtype, has drawn increasing atte...

Jul 8 2026 42418130
Transformer-Based Deep Learning Model for Predicting Hemoglobin Response to Mircera® in Hemodialysis Patients.

BACKGROUND: Anemia management in hemodialysis (HD) depends on individualized erythropoiesis-stimulating agent (ESA) dosing to achieve and maintain tar...

Jul 8 2026 42418351
Artificial Intelligence Diagnosis of Obstructive Sleep Apnea Using Overnight Pulse Oximetry: A Systematic Review and Bayesian Meta-Analysis.

BACKGROUND: Obstructive sleep apnea (OSA) affects 38% of the population, yet over 90% of cases remain undiagnosed. The gold standard for diagnosis, po...

Jul 8 2026 42418449
Conceptualization, Operationalization, and Measurement of Adherence to Patient-Facing Digital Health Applications: Protocol for a Scoping Review.

BACKGROUND: Medical adherence is traditionally defined as the extent to which a person's behavior corresponds with agreed-upon recommendations from a ...

Jul 8 2026 42418694
AI-Based Models for Diabetic Foot Ulcer Assessment: Scoping Review.

BACKGROUND: Diabetic foot ulcers (DFU) are serious complications of diabetes that contribute substantially to morbidity, mortality, and health care bu...

Jul 8 2026 42418768
Service Robots as Work Support for Health Personnel in Long-Term Care: Protocol for a Scoping Review.

BACKGROUND: Demographic shifts are increasing the global demand for long-term care services, coinciding with a worldwide shortage of health care perso...

Jul 8 2026 42418825
Physics-informed, uncertainty-aware surrogate screening of gamma-ray attenuation in lead-free multicomponent oxide glasses.

Lead-free multicomponent oxide glasses are attractive candidates for gamma-ray shielding because their attenuation behavior can be tuned through compo...

Jul 8 2026 42418864
Plasticizer-related toxicogenomic signatures in gestational diabetes: Mendelian randomization, placental single-cell transcriptomics and trophoblast validation.

Plasticizer exposure has been associated with gestational diabetes mellitus (GDM), but the placental toxicogenomic mechanisms that may connect environ...

Jul 8 2026 42418975
Biological aging and the incidence and progression of diabetic retinopathy and kidney disease in type 2 diabetes mellitus: A prospective cohort study.

AIMS: We examined whether phenotypic age (PhenoAge) acceleration was associated with the incidence and progression of diabetic retinopathy (DR) and di...

Jul 8 2026 42419488
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