Primary Care

Latest AI and machine learning research in primary care for healthcare professionals.

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Managing Diabetic Retinopathy with Deep Learning: A Data Centric Overview

Diabetic Retinopathy (DR) is a serious microvascular complication of diabetes, and one of the leading causes of vision loss worldwide. Although automated detection and grading, with Deep Learning (DL), can reduce the burden on ophthalmologists, it is constrained by the limited availability of high-quality datasets. Existing repositories often remain geographically narrow, contain limited samples, ...

Apr 2 2026 2604.02448v1

Development and validation of an XGBoost model with SHAP-based interpretability and a web-based calculator for predicting extrauterine growth restriction in preterm infants

Background: Extrauterine growth restriction (EUGR) is a common and clinically significant complication among preterm infants, contributing to adverse neurodevelopmental and metabolic outcomes. Early and individualized risk prediction remains challenging. This study aimed to develop and validate an interpretable machine learning model for early prediction of EUGR using routinely available clinical ...

Evaluating the Large Language Model-Based Quality Assurance Tool for Auto-Contouring

Purpose: Manual verification of AI-based auto-contouring is labor-intensive and prone to fatigue-related errors. This study developed the large langua...

Aging Signals on Chest Radiographs: Association of Chest Radiograph-Derived Age Acceleration With Future Lung Cancer Incidence

Purpose: To evaluate whether chest radiograph-derived age acceleration is associated with incident lung cancer and whether it improves discrimination ...

Screening for prostate cancer using PSA with and without MRI: systematic reviews with meta-analysis

Background: Previous recommendations on screening for prostate cancer relied on ongoing trials of screening with prostate-specific antigen (PSA), whic...

Evolutionary exploration of drug-like chemical space utilizing generative AI and virtual screening

The identification of suitable lead molecules in the vast chemical space is a critical and challenging task in drug discovery campaigns. Recently, it ...

Retinal microvascular features are associated with CMR measures of subclinical cardiovascular dysfunction

Background Microvascular dysfunction is a key component of many cardiovascular (CV) diseases. Assessing the retinal microvasculature through retinal i...

Comparison of United Kingdom (UK) and United States (U.S.) hypertension treatment status, physical activity and prospective mortality risk

Background: The 2017 American College of Cardiology/American Heart Association (ACC/AHA) guideline lowered diagnostic threshold for hypertension, enco...

Predicting Infant Nonattendance at the Next Recommended Well-Child Visit: Model Development and Validation

BackgroundWell-child visits (WCVs) are essential for preventive care, yet missed appointments often lead to delayed interventions. We developed and va...

Gap Safe Screening Rules for Fast Training of Robust Support Vector Machines under Feature Noise

Robust Support Vector Machines (R-SVMs) address feature noise by adopting a worst-case robust formulation that explicitly incorporates uncertainty set...

Mar 26 2026 2603.25221v1
VOLMO: Versatile and Open Large Models for Ophthalmology

Vision impairment affects millions globally, and early detection is critical to preventing irreversible vision loss. Ophthalmology workflows require c...

Mar 25 2026 2603.23953v2
The Generative AI Meta-Evaluation (GAME) Study Framework: Global, Regional, and Country-Specific Unequal Difficulty of High BMI Intervention

Background High body mass index (BMI) presents a serious and ongoing global health challenge. However, the difficulty of high BMI intervention has not...

Brieflow: An Integrated Computational Pipeline for High-Throughput Analysis of Optical Pooled Screening Data

Optical pooled screening (OPS) has emerged as a powerful technique for functional genomics, enabling researchers to link genetic perturbations with co...

VOLMO: Versatile and Open Large Models for Ophthalmology

Vision impairment affects millions globally, and early detection is critical to preventing irreversible vision loss. Ophthalmology workflows require c...

Mar 25 2026 2603.23953v1
Continuous-Time Learning of Probability Distributions: A Case Study in a Digital Trial of Young Children with Type 1 Diabetes

Understanding how biomarker distributions evolve over time is a central challenge in digital health and chronic disease monitoring. In diabetes, chang...

Mar 25 2026 2603.24427v1
Retinal Disease Classification from Fundus Images using CNN Transfer Learning

Retinal diseases remain among the leading preventable causes of visual impairment worldwide. Automated screening based on fundus image analysis has th...

Mar 24 2026 2603.23785v1
SleepJEPA: Learning the latent world of sleep with at-home sleep data to estimate disease risk

Sleep disturbances lead to risk for cardiovascular (CV), metabolic, and neurological diseases. While in-lab polysomnography (PSG) is the gold standard...

Balancing Safety and Efficiency in Aircraft Health Diagnosis: A Task Decomposition Framework with Heterogeneous Long-Micro Scale Cascading and Knowledge Distillation-based Interpretability

Whole-aircraft diagnosis for general aviation faces threefold challenges: data uncertainty, task heterogeneity, and computational inefficiency. Existi...

Mar 24 2026 2603.22885v1
Social Determinants of Health and Chronic Disease Risk Prediction in the All of Us Research Program

Social determinants of health (SDoH), the social, economic, and environmental conditions shaping health trajectories, contribute to chronic disease ri...

Clinical Graph-Mediated Distillation for Unpaired MRI-to-CFI Hypertension Prediction

Retinal fundus imaging enables low-cost and scalable hypertension (HTN) screening, but HTN-related retinal cues are subtle, yielding high-variance pre...

Mar 23 2026 2603.21809v1
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