Primary Care

Latest AI and machine learning research in primary care for healthcare professionals.

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Showing 5521-5540 of 17,225 articles

Experience-Guided Self-Adaptive Cascaded Agents for Breast Cancer Screening and Diagnosis with Reduced Biopsy Referrals

We propose an experience-guided cascaded multi-agent framework for Breast Ultrasound Screening and Diagnosis, called BUSD-Agent, that aims to reduce diagnostic escalation and unnecessary biopsy referrals. Our framework models screening and diagnosis as a two-stage, selective decision-making process. A lightweight `screening clinic' agent, restricted to classification models as tools, selectively f...

Feb 27 2026 2602.23899v1

Machine learning-based prediction of cardiovascular disease risk in Africa using WHO Stepwise Surveys: 2014-2019

Introduction: Cardiovascular diseases (CVDs) are the leading cause of death globally, with rising burdens in Africa due to ageing populations, lifestyle changes, and poor risk factor control. Conventional risk scores developed in high-income settings often perform poorly in African populations. Machine-learning (ML) approaches offer potential to improve prediction by capturing complex, non-linear ...

A Benchmarking Study of Feature Screening Approaches Across Omics Classification Settings

In recent years, high dimensional omics analyses have become more commonplace for investigating complex biological systems. Typically, these studies a...

Smart stethoscope for cardiac auscultation in general practice: a prospective feasibility study of AI-assisted detection of atrial fibrillation, heart failure, and valvular heart disease

Objectives: Artificial intelligence (AI) enabled digital stethoscopes combine phonocardiography and electrocardiography to support detection of cardia...

Efficient endometrial carcinoma screening via cross-modal synthesis and gradient distillation

Early detection of myometrial invasion is critical for the staging and life-saving management of endometrial carcinoma (EC), a prevalent global malign...

Feb 23 2026 2602.19822v1
AI-Detected Asymptomatic Atrial Fibrillation and Risk of Incident Ischemic Stroke and Cardiovascular Events: A UK Biobank Study

Background: Advances in wearable devices and machine-learning-based ECG analysis enable highly accurate detection of atrial fibrillation (AF) outside ...

AI-DRIVEN DIAGNOSIS OF NON-ALCOHOLIC FATTY LIVER DISEASE AND ASSOCIATED COMORBIDITIES

Non-alcoholic fatty liver disease (NAFLD) is a globally prevalent hepatic condition caused by the buildup of fat in the liver. It is frequently associ...

Deep Agentic Variant Prioritisation for Expert Level Genetic Diagnosis Fast at Scale

Abstract. Genetic diagnosis remains a formidable challenge characterized by a diagnostic odyssey that spans years, with over half of rare disease pati...

RosetteArray Platform for Quantitative High-Throughput Screening of Human Neurodevelopmental Risk

Neural organoids have revolutionized how human neurodevelopmental disorders (NDDs) are studied. Yet, their utility for screening chemical hazards and ...

Collaborative large language models (LLMs) are all you need for screening in systematic reviews

Background: The ability of large language models (LLMs) to work collaboratively and screen studies in a systematic review (SR) is under-explored. Henc...

Multi-Model Clinical Validation of an AI-Powered Biomarker Analysis Framework: A Cross-Vendor Benchmark on 4,018 NHANES Patients

Background: Large language models (LLMs) show promise for clinical decision support, yet most validation studies evaluate single models, leaving quest...

BindCLIP: A Unified Contrastive-Generative Representation Learning Framework for Virtual Screening

Virtual screening aims to efficiently identify active ligands from massive chemical libraries for a given target pocket. Recent CLIP-style models such...

Feb 16 2026 2602.15236v1
Protocol for a prospective accuracy study on an artificial intelligence-based ultrasound system for gestational age estimation among pregnant women in Ghana, Kenya and South Africa

Background: Risk screening for pre-eclampsia relies on accurate gestational age assessment, but routine access to ultrasound-based gestational dating ...

Patterns of preventable death and government response compliance across Australian coronial jurisdictions: a natural language processing analysis of 9833 findings

ABSTRACT Objectives: To quantify patterns of preventable death in Australian coronial findings, measure government compliance with coroner recommendat...

CausalCellInfer: Resolving cell-type-specific disease mechanisms from biobank-scale GWAS

Integrating the cellular resolution of single-cell RNA sequencing (scRNA-seq) with the phenotypic depth of population-scale biobanks is essential for ...

A radiation-free screening system for adolescent idiopathic scoliosis using deep learning on 3D back surface point clouds

Widespread screening for Adolescent Idiopathic Scoliosis (AIS) is critical for timely intervention but is currently constrained by the radiation risks...

Genomics link obesity and type 2 diabetes to Alzheimer's disease to unveil novel biological insights

Body mass index (BMI), type 2 diabetes (T2D) and associated cardiometabolic features modify Alzheimer's disease (AD) risk, yet shared mechanisms remai...

Cellular Aging Signatures in the Plasma Proteome Record Human Health and Disease

Aging is asynchronous across cells and organs, but whether plasma proteins can capture cell type-specific aging and predict disease and mortality rema...

AI-Driven Clinical Decision Support System for Enhanced Diabetes Diagnosis and Management

Identifying type 2 diabetes mellitus can be challenging, particularly for primary care physicians. Clinical decision support systems incorporating art...

Feb 11 2026 2602.11237v1
Causal Effects of Natural Language Processing-Enhanced Clinical Decision Support on Early Cognitive Impairment Detection: A Propensity Score Analysis Using Inverse Probability of Treatment Weighting

Background: Natural language processing (NLP) systems integrated into clinical workflows show promise for detecting early cognitive impairment, yet ca...

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