Primary Care

Latest AI and machine learning research in primary care for healthcare professionals.

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Decoupling Accuracy and Explainability: Machine Learning Strategies for HbA1c Prediction and Biomarker Discovery in Blood FTIR Spectroscopy

Glycated hemoglobin (HbA1c) is a central biomarker for long-term glycemic control and diabetes management, traditionally quantified using laboratory-intensive chromatographic or immunochemical assays. As the global burden of diabetes continues to rise, there is growing interest in alternative, scalable approaches capable of rapid biochemical assessment. Fourier-transform infrared (FTIR) spectrosco...

Glance and Focus Reinforcement for Pan-cancer Screening

Pan-cancer screening in large-scale CT scans remains challenging for existing AI methods, primarily due to the difficulty of localizing diverse types of tiny lesions in large CT volumes. The extreme foreground-background imbalance significantly hinders models from focusing on diseased regions, while redundant focus on healthy regions not only decreases the efficiency but also increases false posit...

Jan 27 2026 2601.19103v1
Time-to-Injury Forecasting in Elite Female Football: A DeepHit Survival Approach

Injury occurrence in football poses significant challenges for athletes and teams, carrying personal, competitive, and financial consequences. While m...

Jan 27 2026 2601.19479v1
Predicting Gene Disease Associations in Type 2 Diabetes Using Machine Learning on Single-Cell RNA-Seq Data

Diabetes is a chronic metabolic disorder characterized by elevated blood glucose levels due to impaired insulin production or function. Two main forms...

RareAlert: Aligning heterogeneous large language model reasoning for early rare disease risk screening

Missed and delayed diagnosis remains a major challenge in rare disease care. At the initial clinical encounters, physicians assess rare disease risk u...

Jan 26 2026 2601.18132v1
Fair-Eye Net: A Fair, Trustworthy, Multimodal Integrated Glaucoma Full Chain AI System

Glaucoma is a top cause of irreversible blindness globally, making early detection and longitudinal follow-up pivotal to preventing permanent vision l...

Jan 26 2026 2601.18464v1
Deep Learning Decodes Latent ECG Signatures of Stress Cardiomyopathy

Background Stress cardiomyopathy (SCM) shares features with acute myocardial infarction (AMI) which may lead to misdiagnosis and misaligned management...

AlphaGenome -enabled analysis of non-coding regulatory variants underlying RHD Expression

Systematic identification of functional non-coding regulatory variants remains a major challenge in human genetics. Conventional approaches such as la...

Clinical and Cross-Domain Validation of an LLM-Guided, Literature-Based Gene Prioritization Framework

Background: We previously published a literature based pipeline for sepsis gene prioritization (PS3 and candidate genes) using an LLM enabled retrieva...

Reasoning-Enhanced Rare-Event Prediction with Balanced Outcome Correction

Rare-event prediction is critical in domains such as healthcare, finance, reliability engineering, customer support, aviation safety, where positive o...

Jan 23 2026 2601.16406v1
Student Mental Health Screening via Fitbit Data Collected During the COVID-19 Pandemic

College students experience many stressors, resulting in high levels of anxiety and depression. Wearable technology provides unobtrusive sensor data t...

Jan 22 2026 2601.16324v1
Camera-Agnostic Autonomous Diagnosis of Glaucomatous Optic Neuropathy using Macular Fundus Imaging and Machine Learning

Abstract Purpose: Glaucoma, a leading cause of irreversible vision loss, often remains undiagnosed due to its asymptomatic progression and the limitat...

Using Natural Language Processing of Clinical Notes to Supplement Structured Electronic Health Record Data for Phenotyping Smoking and Obesity in a Healthcare System

Purpose: Studies based on electronic health records (EHR) often rely on structured data, which may incompletely capture important clinical phenotypes ...

Early Prediction of Type 2 Diabetes Using Multimodal data and Tabular Transformers

This study introduces a novel approach for early Type 2 Diabetes Mellitus (T2DM) risk prediction using a tabular transformer (TabTrans) architecture t...

Jan 19 2026 2601.12981v1
Structured Insight from Unstructured Data: Large Language Models for SDOH-Driven Diabetes Risk Prediction

Social determinants of health (SDOH) play a critical role in Type 2 Diabetes (T2D) management but are often absent from electronic health records and ...

Jan 19 2026 2601.13388v1
GEOGRAPHIC DOMAIN SHIFT PRECIPITATES DIVERGENT FAILURE MODES IN DEEP LEARNING BASED TUBERCULOSIS SCREENING: A MULTI-NATIONAL EXTERNAL VALIDATION STUDY

Background: Deep learning algorithms for tuberculosis (TB) screening frequently achieve radiologist-level performance during internal evaluation, yet ...

Pharmacogenomic Determinants of Post-Liver Transplant Diabetes Mellitus: A Systematic Review and In Silico Pharmacogenomic Analysis

Introduction: Tacrolimus remains central to liver transplantation, yet its narrow therapeutic index and pharmacokinetic variability are associated wit...

A Hierarchical Benchmark of Foundation Models for Dermatology

Foundation models have transformed medical image analysis by providing robust feature representations that reduce the need for large-scale task-specif...

Jan 18 2026 2601.12382v1
Explainable Machine Learning for Pediatric Dental Risk Stratification Using Socio-Demographic Determinants

Background: Pediatric dental disease remains one of the most prevalent and inequitable chronic health conditions worldwide. Although strong epidemiolo...

Jan 18 2026 2601.12405v1
LIBRA: Language Model Informed Bandit Recourse Algorithm for Personalized Treatment Planning

We introduce a unified framework that seamlessly integrates algorithmic recourse, contextual bandits, and large language models (LLMs) to support sequ...

Jan 17 2026 2601.11905v1
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