Primary Care

Latest AI and machine learning research in primary care for healthcare professionals.

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Multi-omics integration identifies macrophage senescence driven by the RUNX1-P53 axis as a key mechanism in diabetic foot ulcer.

Diabetic foot ulcer (DFU) is a severe complication of diabetes, characterized by chronic inflammation and impaired healing. Although cellular and immunosenescence are associated with chronic wounds, the specific cell types, regulatory mechanisms, and pathological consequences within the DFU microenvironment remain poorly defined. We conducted an integrative multi-omics analysis combining bulk and ...

Jul 4 2026 42399485

Diagnostic Tests for Stage B Heart Failure.

PURPOSE OF THE REVIEW: To provide an overview of diagnostic tests for Stage B heart failure (SBHF), synthesizing evidence from guidelines and clinical studies. RECENT FINDINGS: Advances in diagnostic technologies have expanded the ability to identify subclinical myocardial remodelling and early myocardial injury before symptom onset. We highlight the central role of transthoracic echocardiography ...

Jul 4 2026 42399514
Evolving role of biomarkers beyond prostate‑specific antigen in refining prostate cancer screening: From blood‑based tests to urinary and genetic markers (Review).

Prostate‑specific antigen (PSA) screening reduces prostate cancer (PCa) mortality but is limited by overdiagnosis and poor specificity for clinically ...

Jul 3 2026 42396659
Pediatric precision sleep network: a study protocol for identifying sleep signatures of mental health risk in peri-adolescents.

BACKGROUND: Peri-adolescence (ages 10-13) is a sensitive-and clinically critical-developmental window for the emergence of psychiatric symptoms, yet s...

Jul 3 2026 42393597
Associations of Accelerometer-Derived "Weekend Warrior" Physical Activity Pattern With Incident First Cardiometabolic Disease and Cardiometabolic Multimorbidity in Individuals With Hypertension.

BACKGROUND: To examine associations between accelerometer-derived "weekend warrior" (WW) physical activity pattern (most moderate-to-vigorous-intensit...

Jul 3 2026 42396800
Metabolomic signature reveals dysregulated lipoprotein profile in m.3243A>G carriers: a case-control study.

INTRODUCTION: The pathogenic mitochondrial gene variant m.3243A>G disrupts oxidative phosphorylation and is associated with insulin resistance, both o...

Jul 3 2026 42397637
Development of a predictive model for postoperative body mass index and diabetes outcomes after metabolic bariatric surgery: retrospective cohort study.

BACKGROUND: Predicting postoperative body mass index (BMI) trajectories and long-term type 2 diabetes (T2D) remission after bariatric surgery remains ...

Jul 3 2026 42398077
Screening for tuberculosis in prisons: efficacy of a breath-based diagnostic approach in a high prevalence setting.

BACKGROUND: Tuberculosis (TB) remains a major health threat in prisons, where overcrowding and limited access to care facilitate transmission. We eval...

Jul 3 2026 42398697
Prediction of Type 2 Diabetes Mellitus From Chest X-Rays Using a Suite of Previously Developed Chronic Disease Deep Learning Models in an Ethnically Diverse Cohort: Observational Study.

BACKGROUND: Screening for type 2 diabetes (T2D) is not optimal, leading to a large number of patients being undiagnosed. Recently, deep learning (DL) ...

Jul 3 2026 42398923
Homogeneity of Liver Fat Distribution Serves as a Diagnostic Marker for Metabolic Dysfunction-Associated Steatohepatitis.

RATIONALE AND OBJECTIVES: To characterize liver fat distribution in metabolic dysfunction-associated steatohepatitis (MASH) and propose a magnetic res...

Jul 3 2026 42399173
Body composition's effect on the bone-vascular axis of osteoporosis discovered in AI-based CT analysis of COPD patients.

OBJECTIVES: This study aimed to investigate the effect of body composition on the inverse relationship between vertebral bone density (T12 BMD) and to...

Jul 3 2026 42399449
Machine learning-assisted prediction of obstructive sleep apnea in patients with metabolic dysfunction-associated steatotic liver disease: a multicenter study with external validation.

BACKGROUND: Metabolic dysfunction-associated steatotic liver disease (MASLD) is closely associated with obstructive sleep apnea (OSA) through shared m...

Jul 3 2026 42399746
Development and validation of machine learning models for obstructive sleep apnea risk stratification in high-risk pregnant women.

BACKGROUND: Obstructive sleep apnea (OSA) affects approximately 15% of pregnancies and is associated with adverse maternal and fetal outcomes. Althoug...

Jul 3 2026 42399832
Artificial neural network modelling using complete blood count for the early detection of black lung disease among Indonesian coal miner: A retrospective longitudinal study.

BACKGROUND: Black lung disease remains a major occupational health problem among coal miners and is frequently diagnosed at an advanced stage, limitin...

Jul 2 2026 42400964
Heritage cracks dataset: Superficial damage.

The Heritage Cracks dataset contains a total of 1,716 high-resolution images documenting superficial cracking in ignimbrite masonry and lime-based pla...

Jul 2 2026 42472180
Evaluation of the Efficacy of Artificial Intelligence-Based Screening for Diabetic Retinopathy in a Predominantly Non-White Population.

OBJECTIVE: To evaluate the diagnostic accuracy of Luminetics Core, a Food and Drug Administration-cleared artificial intelligence-based screening syst...

Jul 2 2026 42397780
Advancements in wearable technology for heart failure patients.

PURPOSE OF REVIEW: While pharmacologic and device therapies have improved heart failure care in recent decades, age-adjusted rehospitalization rates r...

Jul 2 2026 42388093
Prediction of Clinically Significant Depressive Symptoms at 2-Year Follow-Up in Older Adults: Machine Learning Study Using the English Longitudinal Study of Ageing.

BACKGROUND: Depression in older adults is often underdiagnosed due to atypical symptom presentation and generational stigma, leading to delayed interv...

Jul 2 2026 42390822
A Validated, Modifiable Proteomic Score from the EXSCEL Trial Predicts Cardiovascular Events in Diabetes.

Adults with type 2 diabetes mellitus (T2DM) are at increased risk for stroke, myocardial infarction, and cardiovascular death, yet individual risk is ...

Jul 2 2026 42390946
The 2026 global roadmap for textile-integrated wearable technologies in health.

Wearable and textile-based technologies are transforming health monitoring by enabling continuous, non-invasive, and context-aware assessment of physi...

Jul 2 2026 42392179
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