Latest AI and machine learning research in primary care for healthcare professionals.
Metabolic dysfunction–associated steatotic liver disease (MASLD) often coexists with chronic hepatitis B (CHB), yet early diagnosis remains challenging, particularly in non-obese patients or those with subclinical features. This study aimed to identify metabolic signatures of CHB-related MASLD and construct a predictive model using untargeted metabolomics integrated with machine learning. Serum me...
Cell shape is a fundamental determinant of tissue architecture and organ function. In epithelial tissues, cytoskeletal organization and tight junctions regulate cell geometry, shaping functional tissue units. Disruption of these mechanisms may cause diseases such as autosomal dominant polycystic kidney disease (ADPKD), in which cyst formation is characterized by abnormal regulation of epithelial c...
Extracellular vesicles (EVs), including exosomes, are emerging as promising carriers of disease-specific biomarkers due to their molecular cargo refle...
Satiation is essential for energy homeostasis and is dysregulated in metabolic disorders like obesity and eating disorders such as anorexia nervosa. W...
Type 1 diabetes (T1D) is associated with microbial dysbiosis. While most research has focused on the gut microbiome, limited data address the role of ...
While extensive efforts have characterized lymphoid populations that contribute to pancreatic ‘insulitis’ in type 1 diabetes, significant gaps remain ...
Multiple studies have highlighted the human microbiome’s potential as a biomarker for diagnosing diseases through its interaction with systems like th...
The nasopharyngeal microbiome acts as a dynamic interface between the human body and environmental exposures, modulating immune responses and helping ...
RNA-based therapies are a rapidly expanding field, offering treatments for a wide range of diseases, including many rare conditions. To date, 24 RNA t...
Multiple positive-sense, single-stranded RNA (+ssRNA) viruses cause human diseases, ranging from mild colds to deadly pandemics. These viruses share a...
Type 1 diabetes mellitus (T1DM) is the most common severe chronic disease in children and adolescents and requires life-long exogenous insulin treatme...
HyperLab, developed by HITS, is a web-based, AI-driven drug discovery platform designed to increase research efficiency for experimental drug discover...
In type 2 diabetes (T2D), molecular pathways driving β cell failure are difficult to resolve with standard single cell analysis. Here we developed an ...
Polygenic Risk Scores (PRS) are emerging tools for predicting an individual’s genetic risk for complex diseases. However, their usefulness in clinical...
Metabolic dysfunction-associated steatotic liver disease (MASLD, previously NAFLD) is a frequent co-morbidity of obesity and diabetes, with prevalence...
In hematology/oncology clinics, molecular diagnostics based on nucleic acid sequencing or hybridization are routinely employed to detect malignancy-as...
Muscle atrophy poses a serious threat to human health, with its primary pathogenic mechanisms closely linked to oxidative stress. This study focuses o...
Inflammation is central to pulmonary arterial hypertension (PAH) pathogenesis. The liver regulates systemic immunity, yet its contribution to PAH rema...
Histologically stained tissue sections are considered the gold standard for studying microscopic anatomy and diagnosing disease in clinical practice. ...
Lead optimization plays an important role in preclinical drug discovery. While deep learning has accelerated this process, structure-based approaches ...