Primary Care

Latest AI and machine learning research in primary care for healthcare professionals.

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Showing 621-640 of 17,188 articles

Lung ultrasound in interstitial lung disease: from bedside screening to prognostic integration and AI-assisted standardization.

Interstitial lung diseases (ILDs) require early recognition and longitudinal assessment, yet repeated high-resolution computed tomography (HRCT) is often limited by access, cost, and cumulative radiation exposure, particularly in connective tissue disease-associated ILD (CTD-ILD). Lung ultrasound (LUS) is a bedside, radiation-free, repeatable adjunct that primarily evaluates B-line burden and pleu...

Jun 30 2026 42379532

Epigenetic-Genetic Crosstalk at the Cancer-Diabetes Interface: Convergent Molecular Pathways, Multi-Omics Biomarkers, and Dual Therapeutic Targets.

The complex interdependence between cancer and diabetes has become a major subject of research in molecular medicine since multiple data points indicate that these two conditions have some molecular processes and regulatory pathways in common. The complex relationship between epigenetic and genetic modifications linking these two prevalent diseases was explored in this comprehensive study. Molecul...

Jun 30 2026 42313898
European Cancer Prevention Organization on cancer screening: an expert panel position paper.

BACKGROUND: Cancer screening is a cornerstone of cancer control in Europe yet marked disparities persist in access, implementation, and quality assura...

Jun 30 2026 42366611
Postoperative cerebral infarction after major thoracic and abdominopelvic surgery: a retrospective single-centre cohort study of incidence, risk factors, and outcomes.

BACKGROUND: Postoperative cerebral infarction (POCI) is an uncommon but potentially fatal complication of major non-cardiac surgery and is associated ...

Jun 30 2026 42374193
Deep learning of multiplexed mitochondrial morphology identified natural compound combinations against skin photoaging.

BACKGROUND: Skin photoaging is primarily driven by mitochondrial dysfunction. Although natural products have demonstrated protective effects against U...

Jun 29 2026 42407185
Deep learning analysis of ECGs detects Cardiovascular-Kidney-Metabolic syndrome burden in people with diabetes: a report from the Silesia Diabetes-Heart Project.

BACKGROUND: Cardiovascular-kidney-metabolic (CKM) syndrome refers to the co-occurrence of obesity, diabetes, chronic kidney disease (CKD), and cardiov...

Jun 29 2026 42374510
Statin adherence among patients with hypertension in Swedish primary health care: a QregPV cohort study using explainable machine learning.

AIMS: Evidence regarding statin adherence among patients with hypertension in primary care is limited. We assessed statin adherence in Swedish primary...

Jun 29 2026 42366593
Proteomic signatures as biomarkers of atherosclerosis burden.

AIMS: Atherosclerosis is currently evaluated by imaging, but scalable circulating biomarkers to detect its presence and quantify overall burden are la...

Jun 29 2026 42367007
Artificial Intelligence for Opportunistic Screening for Osteoporosis and Spine Fractures Using Computed Tomography: A Systematic Review and Meta-Analysis.

OBJECTIVE: Osteoporosis is a major global health burden and often remains undiagnosed until fragility fractures occur. Dual-energy x-ray absorptiometr...

Jun 29 2026 42370443
Operationalizing Digital Health Equity in Artificial Intelligence-Enabled Patient Decision Aids for Older Adults: Mixed Methods Study.

BACKGROUND: Artificial intelligence-enabled patient decision aids (AI-PDAs) hold promise for supporting older adults with chronic diseases in accessin...

Jun 29 2026 42372250
Real-world integration of an autonomous artificial intelligence system for diabetic retinopathy screening in an endocrinology outpatient clinic.

AIM: To evaluate a real-world clinical integration of an autonomous artificial intelligence (AI) system (AEYE Diagnostic Screening (AEYE-DS), AEYE Hea...

Jun 29 2026 42373309
Diagnostic Accuracy of Artificial Intelligence-based Automated Detection of Diabetic Retinopathy in Routine Care Using Nonmydriatic Fundus Images: The Silesia Diabetes-Heart Project.

PURPOSE: To evaluate the diagnostic performance of a regulatory-approved (CE-marked) artificial intelligence system (RetCAD) applied to nonmydriatic c...

Jun 29 2026 42373388
Identification and validation of biomarkers associated with mitochondria and glycometabolism in gestational diabetes mellitus.

Gestational diabetes mellitus (GDM) can elevate the likelihood of developing high blood pressure during pregnancy. It is one of the most common compli...

Jun 29 2026 42374095
Dynamic models of occupational fatigue: a systematic review for risk management advancement.

BACKGROUND: Occupational fatigue is a major safety and health risk across work sectors. Because fatigue accumulates and fluctuates over time, effectiv...

Jun 29 2026 42374307
Echocardiographic assessment in arterial hypertension: a contemporary narrative review.

Arterial hypertension remains the leading modifiable cause of cardiovascular morbidity and mortality resulting in characteristic changes in cardiac st...

Jun 29 2026 42366420
Deciphering the Therapeutic and Preventive Potential of Dietary Tannins in Osteosarcoma: A Multi-Omics Approach Targeting TGFA and Immune Microenvironment Remodeling.

Malignant tumors, including osteosarcoma (OS), are major non-communicable chronic diseases driven by systemic inflammation and oxidative stress. While...

Jun 28 2026 42375570
Benchmarking docking and ML re-scoring screening performance for KRAS G12D in pancreatic cancer.

The KRAS G12D mutation is commonly found in pancreatic cancer and is integral to the cell signaling pathway, making it a critical target for drug deve...

Jun 28 2026 42365569
Predictive Model for Thrombosis in Mature Autologous Arteriovenous Fistula.

OBJECTIVE: Based on the "high-risk stenosis-thrombosis" theory, this study developed a risk prediction model for thrombosis in mature autogenous arter...

Jun 28 2026 42365896
Integrated machine learning, molecular docking, and molecular dynamics simulations for in silico identification of GSK3β inhibitors for Alzheimer's disease.

Glycogen Synthase Kinase-3 Beta is a multifunctional serine/threonine kinase, involved in regulating multiple cellular processes. Its dysregulation pl...

Jun 27 2026 42365084
Potential evaluation of SULT1A3 as an early diagnostic marker for nasopharyngeal carcinoma: a study based on serum proteomics screening and ELISA validation.

BACKGROUND: Nasopharyngeal carcinoma (NPC) represents a highly prevalent and aggressive malignancy endemic to Southeast Asia. Early and accurate diagn...

Jun 27 2026 42365246
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