Primary Care

Latest AI and machine learning research in primary care for healthcare professionals.

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Machine learning-based predictive model for sleep disorders in diabetic patients: data analysis from CHARLS.

Sleep disorders are prevalent and constitute a major concern in patients with diabetes mellitus. Therefore, the aim of this study was to investigate the applicability of machine learning methods in predicting sleep disorders among diabetic patients. Six relevant features were selected using single-factor correlation analysis and the LASSO algorithm. We developed and evaluated five ML models: logis...

Jun 18 2026 42315864

Basket and umbrella trials in pediatric precision medicine: a systematic review of designs, opportunities, and challenges.

BACKGROUND: Personalized medicine, driven by genomic insights, has catalyzed the emergence of innovative clinical trial designs such as basket and umbrella trials. These designs are particularly suited for evaluating targeted therapies in biomarker-defined subgroups and rare pediatric conditions where traditional trials face challenges of small sample sizes and disease heterogeneity. OBJECTIVES: T...

Jun 17 2026 42310536
Identification of depression types and key influencing factors among rural elderly in China: a comprehensive analysis based on machine learning and network analysis.

BACKGROUND: Depression poses a severe public health challenge for older adults, especially in rural China. In rural settings, the heavy burden of chro...

Jun 17 2026 42310574
REFLECTIVE-TIAB: cost-effective prompt optimisation for large language model-based title and abstract screening in literature reviews.

BACKGROUND: Title and abstract screening is a labor-intensive stage of systematic reviews. Large language models (LLMs) can automate this process, but...

Jun 17 2026 42311049
Clinical Implementation of Opportunistic Screening for Osteoporosis.

Opportunistic screening leverages existing imaging examinations performed for unrelated routine clinical indications to systematically extract quantit...

Jun 17 2026 42308093
Visceral adipose tissue inflammation in endometrial cancer.

BACKGROUND: Obesity is the largest risk factor for endometrial cancer. Body Mass Index (BMI) does not fully capture obesity's metabolic and inflammato...

Jun 17 2026 42308582
RetiMap: Automated Retinal Vascular Measures Link Microvascular Structure to Metabolic Health and Predict Cardiovascular Risk.

Fundus imaging enables noninvasive, high-resolution visualization of the retinal microvasculature. Advances in artificial intelligence (AI) now allow ...

Jun 17 2026 42308589
Determinants of childhood and adolescent obesity: An explainable AI approach using the ICAD database.

OBJECTIVES: To identify the biological, behavioural, and socio-demographic determinants of childhood and adolescent obesity and evaluate how their rel...

Jun 17 2026 42308771
Machine learning-assisted prediction of PANoptosis-related molecular targets and precise screening of neuroprotective drugs for spinal cord injury.

Spinal cord injury (SCI) is a highly disabling central nervous system disease with complex pathology, and targeted neuroprotective drugs remain clinic...

Jun 17 2026 42309342
Repeatability of AI-quantified incidental findings on lung cancer screening CT scans in the NELSON trial.

OBJECTIVES: Computed tomography (CT) scans for lung cancer screening provide the opportunity of quantifying incidental findings. We evaluated the repe...

Jun 17 2026 42310036
A CD index guided ensemble framework for screening potentially disruptive patent candidates in artificial intelligence.

Disruptive technologies can reconfigure innovation trajectories and create new market opportunities, yet their early detection remains difficult becau...

Jun 17 2026 42310399
Histology-guided 3D virtual staining of microCT-imaged lung tissue via deep learning.

Histologically stained tissue sections are considered the gold standard for studying microscopic anatomy and diagnosing disease in clinical practice. ...

Jun 17 2026 42303257
EDRNet-based adolescent idiopathic scoliosis screening method using bare-back images.

BACKGROUND: Adolescent idiopathic scoliosis (AIS) affects 2-3% of adolescents. Current screening relies on X-rays, which limits large-scale applicatio...

Jun 16 2026 42304329
Validation of latent health behaviour subtypes in young and middle-aged adults with hypertension: a machine learning-augmented LCA approach with external cohort replication.

AIMS: To validate behavioural subtypes among young and middle-aged hypertensive patients using latent class analysis (LCA) and assess their generaliza...

Jun 16 2026 41492921
Persistent social connection over time is associated with attenuated biological ageing assessed by AI-enabled electrocardiography.

AIMS: Social isolation (SI) is associated with a higher risk of cardiovascular disease (CVD). One mechanism linking SI and CVD is accelerated biologic...

Jun 16 2026 42301204
nnU-Net-based CT segmentation of perigastric varices in sinistral portal hypertension: a multicenter study.

PURPOSE: To develop a deep learning model based on nnU-Net for automated segmentation of all perigastric veins on contrast-enhanced CT images in patie...

Jun 16 2026 42301285
Online Intervention on Lung Cancer Screening Among High-Risk Individuals: Pilot Intervention Study.

BACKGROUND: Lung cancer remains the leading cause of cancer deaths in the United States; however, uptake of lung cancer screening (LCS) with low-dose ...

Jun 16 2026 42302275
Comparative Evaluation of Proximal Caries Detection Methods using Human, Artificial Intelligence, and Micro-CT Assessments.

OBJECTIVE: To validate the diagnostic accuracy of ICDAS visual examination, conventional bitewing radiography, and artificial intelligence (AI)-assist...

Jun 16 2026 42303112
Navigating Diabetes Management in the Digital Era: Scoping Review of Online Health Information-Seeking Behavior.

BACKGROUND: Online health information seeking (OHIS) has become a central component of chronic disease management within an increasingly interactive, ...

Jun 16 2026 42303245
Expert Consensus Statement on Acoustic Metrics for Swallowing Dysfunction Screening in Older Adults: A Delphi Study.

OBJECTIVE: Swallowing dysfunction poses significant health risks for older adults. Early detection is crucial to prevent complications such as aspirat...

Jun 16 2026 42303507
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